CAS 34580-14-8

ketotifen fumarate

Description:

Ketotifen fumarate is a pharmaceutical compound primarily used as an antihistamine and mast cell stabilizer, often prescribed for the management of allergic conditions such as asthma and allergic rhinitis. It is a derivative of the compound ketotifen, which is known for its ability to inhibit the release of histamine and other mediators from mast cells. Ketotifen fumarate is typically presented as a white to off-white crystalline powder, which is soluble in water and exhibits a relatively stable profile under standard storage conditions. The fumarate salt form enhances its solubility and bioavailability. The compound acts by blocking H1 histamine receptors and has additional anti-inflammatory properties, making it effective in reducing bronchial hyperreactivity. Its pharmacokinetics involve oral administration, with a notable half-life that allows for once or twice daily dosing. As with any medication, potential side effects may include sedation, dry mouth, and gastrointestinal disturbances, necessitating careful consideration in patients with specific health conditions.

Formula: C₂₃H₂₃NO₅S

InChI: InChI=1/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChI key: InChIKey=YNQQEYBLVYAWNX-WLHGVMLRSA-N

SMILES: O=C1C2=C(C(C=3C(C1)=CC=CC3)=C4CCN(C)CC4)C=CS2.C(=C/C(O)=O)\C(O)=O

Synonyms:

• 1-methyl-4-(10-oxo-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)piperidinium
• 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (E)-2-butenedioate (1:1)
• 10H-Benzo[4,5]cyclohepta[1,2-b]thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (2E)-2-butenedioate (1:1)
• 4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one fumarate
• 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one fumarate (1:1)
• 4,9-Dihydro-4-(1-methylpiperidin-4-yliden)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-onfumarat
• 4,9-Dihydro-4-(1-methylpiperidin-4-ylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophene-10-one fumarate
• 4-(1-methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
• 4-(1-methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one (2E)-but-2-enedioate
• Alaway
• Allerkif
• HC 20,511 fumarate
• Hc 20511
• Ketotifen fumarate [USAN:JAN]
• Ketotifen hydrogen fumarate
• Totifen
• Unii-Hbd503Woro
• Zaditen
• Zaditor
• Zasten
• fumarate de 4,9-dihydro-4-(1-methylpiperidine-4-ylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophene-10-one
• fumarato de 4,9-dihidro-4-(1-metilpiperidin-4-ilideno)-10H-benzo[4,5]ciclohepta[1,2-b]tiofeno-10-ona
• Ketotifen fumarate
• 10h-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one,4,9-dihydro-4-(1-methyl-4-pipe
• KETOTIFEN FUMARATE EP
• KETOTIFEN FUMARATE SALT
• 4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9h)-one hydrogen fumarate
• Ketotifene fumarate
• 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one fumarate
• Anatifen
• hc20-511fumarate

Ketotifen Fumarate

CAS: 34580-14-8

Formula: C₁₉H₁₉NOS·C₄H₄O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 425.50

Ref: 3B-K0048

Ketotifen fumarate, 99%

CAS: 34580-14-8

Ketotifen fumaratin is an H1 receptor antagonist. In its ophthalmic form, it is used to treat allergic conjunctivitis, or the itchy red eyes caused by allergies. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label infor

Formula: C₂₃H₂₃NO₅S

Purity: 99%

Color and Shape: White to pale cream to pale yellow, Powder

Molecular weight: 425.50

Ref: 02-J63708

Ketotifen Hydrogen Fumarate 1.0 mg/ml in Methanol (as free base)

CAS: 34580-14-8

Color and Shape: Single Solution

Ref: 61-AMP0180.00-01

Ketotifen Hydrogen Fumarate

CAS: 34580-14-8

Color and Shape: Neat

Ref: 61-FOR0180.00

KETOTIFEN HYDROGEN FUMARATE CRS

CAS: 34580-14-8

KETOTIFEN HYDROGEN FUMARATE CRS

Formula: C₂₃H₂₃NO₅S

Color and Shape: White. Yellow-Brown. Crystalline Powder.

Molecular weight: 425.4974

Ref: 41-Y0001619

Ketotifen Fumarate

CAS: 34580-14-8

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₉H₁₉NOS·C₄H₄O₄

Color and Shape: White Brownish Yellow Powder

Molecular weight: 309.11874

Ref: 45-1356406

Ketotifen fumarate

CAS: 34580-14-8

Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.

Formula: C₂₃H₂₃NO₅S

Purity: 99.25% - 99.73%

Color and Shape: Solid

Molecular weight: 425.50

Ref: TM-T0994

10H-Benzo[4,5]cyclohepta[1,2-b]thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (E)-2-butenedioate (1:1)

CAS: 34580-14-8

Formula: C₂₃H₂₃NO₅S

Purity: 95%

Color and Shape: Solid

Molecular weight: 425.4974

Ref: IN-DA003R69

Ketotifen Fumarate

CAS: 34580-14-8

Formula: C₁₉H₁₉NOS·C₄H₄O₄

Color and Shape: Off-White Solid

Molecular weight: 309.43 116.07

Ref: 4Z-K-061

Ketotifen fumarate

CAS: 34580-14-8

Ketotifen fumarate

Purity: ≥95%

Molecular weight: 425.5g/mol

Ref: 54-BUP14763

Ketotifen fumarate

CAS: 34580-14-8

Ketotifen fumarate

Formula: C₁₉H₁₉NOS·C₄H₄O₄

Purity: 99.7% (hplc) (Typical Value in Batch COA)

Color and Shape: Solid

Molecular weight: 425.50g/mol

Ref: 54-BIK4000

Ketotifen fumarate

CAS: 34580-14-8

Formula: C₁₉H₁₉NOS·C₄H₄O₄

Purity: ≥ 98%

Color and Shape: White to off-white powder

Molecular weight: 425.50

Ref: 7W-GP2795

Ketotifen Hydrogen Fumarate

Controlled Product

CAS: 34580-14-8

Formula: C₁₉H₁₉NOS·C₄H₄O₄

Color and Shape: Neat

Molecular weight: 425.50

Ref: 86-MM0180.00

Ketotifen Fumarate

Controlled Product

CAS: 34580-14-8

Applications Ketotifen is used as an antiasthmatic. Ketotifen is an antiallergic agent.
References Tsuji, F., et al.: Biol. Pharm. Bull., 33, 1050 (2010), Al O., et al.: J., Mol., Liq., 155, 103 (2010), Uccello-Barretta, G., et al.: Int. J. Pharm., 395, 122 (2010),

Formula: C₁₉H₁₉NOS·C₄H₄O₄

Color and Shape: White

Molecular weight: 425.50

Ref: TR-K315100

Ketotifen fumarate

CAS: 34580-14-8

Ketotifen fumarate is an anti-inflammatory drug that belongs to the class of histamine H1 receptor antagonists. It has been shown to be effective in the treatment of inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. Ketotifen fumarate also has biological properties, such as eosinophil cationic protein release inhibition, that are important for its therapeutic effects. In vitro studies have shown that ketotifen fumarate can inhibit h1-receptor mediated responses in a dose-dependent manner. The drug is metabolized by the liver enzyme CYP3A4 and has been shown to interact with other drugs metabolized through this pathway. Ketotifen fumarate is currently being used as a research tool in experimental models of infectious diseases, such as tuberculosis and influenza A virus infection.

Formula: C₂₃H₂₃NO₅S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 425.5 g/mol

Ref: 3D-FK01539