CAS 34580-14-8
:ketotifen fumarate
Description:
Ketotifen fumarate is a pharmaceutical compound primarily used as an antihistamine and mast cell stabilizer, often prescribed for the management of allergic conditions such as asthma and allergic rhinitis. It is a derivative of the compound ketotifen, which is known for its ability to inhibit the release of histamine and other mediators from mast cells. Ketotifen fumarate is typically presented as a white to off-white crystalline powder, which is soluble in water and exhibits a relatively stable profile under standard storage conditions. The fumarate salt form enhances its solubility and bioavailability. The compound acts by blocking H1 histamine receptors and has additional anti-inflammatory properties, making it effective in reducing bronchial hyperreactivity. Its pharmacokinetics involve oral administration, with a notable half-life that allows for once or twice daily dosing. As with any medication, potential side effects may include sedation, dry mouth, and gastrointestinal disturbances, necessitating careful consideration in patients with specific health conditions.
Formula:C23H23NO5S
InChI:InChI=1/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChI key:InChIKey=YNQQEYBLVYAWNX-WLHGVMLRSA-N
SMILES:O=C1C2=C(C(C=3C(C1)=CC=CC3)=C4CCN(C)CC4)C=CS2.C(=C/C(O)=O)\C(O)=O
Synonyms:- 1-methyl-4-(10-oxo-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)piperidinium
- 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (E)-2-butenedioate (1:1)
- 10H-Benzo[4,5]cyclohepta[1,2-b]thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (2E)-2-butenedioate (1:1)
- 4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one fumarate
- 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one fumarate (1:1)
- 4,9-Dihydro-4-(1-methylpiperidin-4-yliden)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-onfumarat
- 4,9-Dihydro-4-(1-methylpiperidin-4-ylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophene-10-one fumarate
- 4-(1-methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
- 4-(1-methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one (2E)-but-2-enedioate
- Alaway
- Allerkif
- HC 20,511 fumarate
- Hc 20511
- Ketotifen fumarate [USAN:JAN]
- Ketotifen hydrogen fumarate
- Totifen
- Unii-Hbd503Woro
- Zaditen
- Zaditor
- Zasten
- fumarate de 4,9-dihydro-4-(1-methylpiperidine-4-ylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophene-10-one
- fumarato de 4,9-dihidro-4-(1-metilpiperidin-4-ilideno)-10H-benzo[4,5]ciclohepta[1,2-b]tiofeno-10-ona
- Ketotifen fumarate
- 10h-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one,4,9-dihydro-4-(1-methyl-4-pipe
- KETOTIFEN FUMARATE EP
- KETOTIFEN FUMARATE SALT
- 4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9h)-one hydrogen fumarate
- Ketotifene fumarate
- 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one fumarate
- Anatifen
- hc20-511fumarate
- See more synonyms
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Ketotifen Fumarate
CAS:Formula:C19H19NOS·C4H4O4Purity:>98.0%(HPLC)(T)Color and Shape:White to Almost white powder to crystalMolecular weight:425.50Ketotifen fumarate, 99%
CAS:Ketotifen fumaratin is an H1 receptor antagonist. In its ophthalmic form, it is used to treat allergic conjunctivitis, or the itchy red eyes caused by allergies. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label inforFormula:C23H23NO5SPurity:99%Color and Shape:White to pale cream to pale yellow, PowderMolecular weight:425.50KETOTIFEN HYDROGEN FUMARATE CRS
CAS:KETOTIFEN HYDROGEN FUMARATE CRSFormula:C23H23NO5SColor and Shape:White. Yellow-Brown. Crystalline Powder.Molecular weight:425.4974Ketotifen Fumarate
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C19H19NOS·C4H4O4Color and Shape:White Brownish Yellow PowderMolecular weight:309.1187410H-Benzo[4,5]cyclohepta[1,2-b]thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (E)-2-butenedioate (1:1)
CAS:Formula:C23H23NO5SPurity:95%Color and Shape:SolidMolecular weight:425.4974Ketotifen fumarate
CAS:Ketotifen fumarateFormula:C19H19NOS·C4H4O4Purity:99.7% (hplc) (Typical Value in Batch COA)Color and Shape:SolidMolecular weight:425.49741Ketotifen fumarate
CAS:Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.Formula:C23H23NO5SPurity:99.25% - 99.73%Color and Shape:White SolidMolecular weight:425.497Ketotifen Fumarate
CAS:Formula:C19H19NOS·C4H4O4Color and Shape:Off-White SolidMolecular weight:309.43 116.07Ketotifen fumarate
CAS:Formula:C19H19NOS·C4H4O4Purity:≥ 98%Color and Shape:White to off-white powderMolecular weight:425.50Ketotifen Hydrogen Fumarate
CAS:Controlled ProductFormula:C19H19NOS·C4H4O4Color and Shape:NeatMolecular weight:425.50Ketotifen Fumarate
CAS:Controlled ProductApplications Ketotifen is used as an antiasthmatic. Ketotifen is an antiallergic agent.
References Tsuji, F., et al.: Biol. Pharm. Bull., 33, 1050 (2010), Al O., et al.: J., Mol., Liq., 155, 103 (2010), Uccello-Barretta, G., et al.: Int. J. Pharm., 395, 122 (2010),Formula:C19H19NOS·C4H4O4Color and Shape:NeatMolecular weight:425.5Ketotifen fumarate
CAS:Ketotifen fumarate is an anti-inflammatory drug that belongs to the class of histamine H1 receptor antagonists. It has been shown to be effective in the treatment of inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. Ketotifen fumarate also has biological properties, such as eosinophil cationic protein release inhibition, that are important for its therapeutic effects. In vitro studies have shown that ketotifen fumarate can inhibit h1-receptor mediated responses in a dose-dependent manner. The drug is metabolized by the liver enzyme CYP3A4 and has been shown to interact with other drugs metabolized through this pathway. Ketotifen fumarate is currently being used as a research tool in experimental models of infectious diseases, such as tuberculosis and influenza A virus infection.
Formula:C23H23NO5SPurity:Min. 95%Color and Shape:White PowderMolecular weight:425.5 g/mol
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