CAS 348-57-2

1-Bromo-2,4-difluorobenzene

Description:

1-Bromo-2,4-difluorobenzene is an aromatic halogenated compound characterized by the presence of a bromine atom and two fluorine atoms attached to a benzene ring. Its molecular formula is C6H3BrF2, indicating that it contains six carbon atoms, three hydrogen atoms, one bromine atom, and two fluorine atoms. This compound is typically a colorless to pale yellow liquid with a distinctive aromatic odor. It is known for its moderate volatility and relatively low solubility in water, making it more soluble in organic solvents. 1-Bromo-2,4-difluorobenzene is utilized in various chemical synthesis processes, particularly in the production of pharmaceuticals and agrochemicals. Its reactivity is influenced by the electron-withdrawing effects of the fluorine atoms, which can enhance electrophilic substitution reactions. Safety precautions are necessary when handling this compound, as it may pose health risks if inhaled or ingested, and appropriate protective measures should be taken to minimize exposure.

Formula: C₆H₃BrF₂

InChI: InChI=1S/C6H3BrF2/c7-5-2-1-4(8)3-6(5)9/h1-3H

InChI key: InChIKey=MGHBDQZXPCTTIH-UHFFFAOYSA-N

SMILES: FC1=C(Br)C=CC(F)=C1

Synonyms:

• 1,4-Dichloro-2-Fluorobenzene
• 2,4-Difluoro-1-bromobenzene
• 2,4-DifluoroBrmorobenzene
• 2,4-Difluorobromobenzene
• 2,4-Difluorophenyl bromide
• 4-Bromo-1,3-difluorobenzene
• Benzene, 1-bromo-2,4-difluoro-
• 1-Bromo-2,4-difluorobenzene
• 4-(Trifluoromethylthio)

1-Bromo-2,4-difluorobenzene

CAS: 348-57-2

Formula: C₆H₃BrF₂

Purity: >98.0%(GC)

Color and Shape: Colorless to Light yellow clear liquid

Molecular weight: 192.99

Ref: 3B-D1909

1-Bromo-2,4-difluorobenzene, 98+%

CAS: 348-57-2

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₆H₃BrF₂

Purity: 98+%

Color and Shape: Clear colorless, Liquid

Molecular weight: 192.99

Ref: 02-A14098

2,4-Difluorobromobenzene

CAS: 348-57-2

2,4-Difluorobromobenzene

Formula: C₆H₃BrF₂

Purity: 98%

Color and Shape: Colourless Liquid

Molecular weight: 192.98882

Ref: 54-PC1382

1-Bromo-2,4-difluorobenzene

CAS: 348-57-2

Formula: C₆H₃BrF₂

Molecular weight: 192.99

Ref: 7W-GK6652

1-Bromo-2,4-difluorobenzene

CAS: 348-57-2

Formula: C₆H₃BrF₂

Purity: 98%

Color and Shape: Liquid

Molecular weight: 192.9888

Ref: IN-DA003E2W

1-Bromo-2,4-difluorobenzene

Controlled Product

CAS: 348-57-2

Applications 1-Bromo-2,4-difluorobenzene is a reactant used in the preparation of azole derivatives as highly-selective fungal CYP51 inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hoekstra, W.J., et. al.: Bioorg. Med. Chem. Lett., 24, 3455 (2014)

Formula: C₆H₃BrF₂

Color and Shape: Neat

Molecular weight: 192.99

Ref: TR-B687875

1-Bromo-2,4-difluorobenzene

CAS: 348-57-2

1-Bromo-2,4-difluorobenzene

Formula: C₆H₃BrF₂

Purity: 97%

Molecular weight: 192.99

Ref: IN-DG33332

1-Bromo-2,4-difluorobenzene

CAS: 348-57-2

Formula: C₆H₃BrF₂

Purity: 98.00%

Color and Shape: Liquid

Molecular weight: 192.991

Ref: 10-F001462

1-Bromo-2,4-difluorobenzene, min. 99%

CAS: 348-57-2

Formula: BrC₆H₃F₂

Purity: min. 99%

Color and Shape: Clear, colorless to very pale-yellow liquid

Molecular weight: 192.99

Ref: 08-09-0007

1-Bromo-2,4-Difluorobenzene pure, 98%

CAS: 348-57-2

Formula: BrC₆H₃F₂

Purity: min. 98.0%

Color and Shape: Clear, Colourless to yellow, Liquid

Molecular weight: 193.00

Ref: SR-38209

2,4-Difluorobromobenzene

CAS: 348-57-2

2,4-Difluorobromobenzene is an efficient method for synthesizing a variety of fluorinated arenes. It is a member of the class of compounds known as fluoroarenes. The synthesis starts with 2-bromobenzene, which reacts with butyllithium in the presence of trifluoroacetic acid to form 2-bromo-4-fluorobenzene. This compound can then be converted to the desired product by treatment with activated carbon or photochromic agents such as benzophenone and tetracyanoethylene. 2,4-Difluorobromobenzene can also be used as a synthetic intermediate for antifungal agents such as fluconazole and it has been shown to have some activity against Cryptococcus neoformans.

Formula: C₆H₃BrF₂

Purity: Min. 95%

Molecular weight: 192.99 g/mol

Ref: 3D-FD16010