CAS 348079-17-4

Ac-IETD-AMC

CAS: 348079-17-4

Ac-IETD-AMC, a fluorogenic substrate specific for caspase-8 and granzyme B with an acetyl (Ac) moiety, is commonly utilized to quantify caspase-8 activity [1].

Formula: C₃₁H₄₁N₅O₁₂

Color and Shape: Solid

Molecular weight: 675.68

Ref: TM-T83181

Ac-Ile-Glu-Thr-Asp-AMC

CAS: 348079-17-4

Ac-Ile-Glu-Thr-Asp-AMC is a reactive, nonsteroidal anti-inflammatory drug that inhibits the activity of survivin, which is an important protein for the survival of prostate cancer cells. Ac-Ile-Glu-Thr-Asp-AMC also inhibits mitochondrial membrane potential in prostate cancer cells and normal peripheral blood mononuclear cells, leading to apoptosis. The biochemical properties of Ac-Ile-Glu-Thr-Asp-AMC are similar to those of other NSAIDs. This drug has been shown to inhibit protein synthesis in experimental models and hydrochloric acid causes mitochondrial membrane depolarization, which triggers apoptosis.

Formula: C₃₁H₄₁N₅O₁₂

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 675.68 g/mol

Ref: 3D-FA110583

Ac-Ile-Glu-Thr-Asp-AMC

CAS: 348079-17-4

Ac-Ile-Glu-Thr-Asp-AMC is a high purity, water soluble peptide consisting of the amino acid sequence Ile-Glu-Thr-Asp. Ac-Ile-Glu-Thr-Asp-AMC has been shown to activate the nicotinic acetylcholine receptor and inhibit ligand binding to the NMDA glutamate receptor in rat cortical neurons. Ac-Ile-Glu-Thr-Asp AMC is also an inhibitor of voltage gated potassium channels and has been used as a research tool for studying ion channel function.

Formula: C₃₁H₄₁N₅O₁₂

Purity: Min. 95%

Molecular weight: 675.68 g/mol

Ref: 3D-MCA-3195-V