CAS 34841-35-5

1-(3-Chlorophenyl)-1-propanone

Description:

1-(3-Chlorophenyl)-1-propanone, also known as 3-Chloroacetophenone, is an organic compound characterized by its ketone functional group and a chlorinated aromatic ring. It typically appears as a colorless to pale yellow liquid with a distinctive odor. The presence of the chlorophenyl group contributes to its chemical reactivity and potential applications in various fields, including pharmaceuticals and agrochemicals. This compound is known for its moderate solubility in organic solvents and limited solubility in water, which is common for many aromatic ketones. Its molecular structure includes a propanone backbone, making it a ketone, while the chlorine substituent on the phenyl ring can influence its electronic properties and reactivity. Safety considerations are important when handling this substance, as it may pose health risks such as irritation to the skin, eyes, and respiratory system. Proper storage and handling protocols should be followed to mitigate any hazards associated with its use.

Formula: C₉H₉ClO

InChI: InChI=1S/C9H9ClO/c1-2-9(11)7-4-3-5-8(10)6-7/h3-6H,2H2,1H3

InChI key: InChIKey=PQWGFUFROKIJBO-UHFFFAOYSA-N

SMILES: C(CC)(=O)C1=CC(Cl)=CC=C1

Synonyms:

• 1-(3-Chlorophenyl)Propan-1-One
• 1-(4-Chlorophenyl)Propan-1-One
• 1-Propanone, 1-(3-chlorophenyl)-
• 2-Chloroethyl phenyl ketone
• 3-Chloro-1-Phenylpropan-1-One
• 3-Chloro-1-phenyl-1-propanone
• 3-Chlorophenyl ethyl ketone
• 3′-Chloropropiophenone
• M-Chlorophenylacetone
• M-Chloropropiophenone
• Propiophenone, 3′-chloro-
• beta-Chloropropiophenone
• beta-Chloropropiophenone/3-Chloro-1-phenyl-1-propanone

3'-Chloropropiophenone

CAS: 34841-35-5

Formula: C₉H₉ClO

Purity: >98.0%(GC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 168.62

Ref: 3B-C2033

3'-Chloropropiophenone, 98%

CAS: 34841-35-5

3'-Chloropropiophenone has been used in the preparation of 1-(3-chlorophenyl)-1-phenyl-1-propanol. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar

Formula: C₉H₉ClO

Purity: 98%

Color and Shape: White to cream, Crystalline powder, granules or chunks

Molecular weight: 168.62

Ref: 02-A12542

Chloropropiophenone (1-(3-Chlorophenyl)propan-1-one)

CAS: 34841-35-5

Aromatic ketones without other oxygen function, nesoi

Formula: C₉H₉ClO

Color and Shape: White Yellow Solid

Molecular weight: 168.03419

Ref: 45-1117020

1-(3-Chlorophenyl)propan-1-one

CAS: 34841-35-5

Formula: C₉H₉ClO

Purity: 98%

Color and Shape: Solid

Molecular weight: 168.6202

Ref: IN-DA003ISG

3'-Chloropropiophenone

CAS: 34841-35-5

3'-Chloropropiophenone

Formula: C₉H₉ClO

Purity: ≥95%

Color and Shape: White Solid

Molecular weight: 168.62015

Ref: 54-OR8786

3''-Chloropropiophenone

CAS: 34841-35-5

Formula: C₉H₉ClO

Purity: ≥ 99.0%

Color and Shape: White, off-white or pale yellow crystalline powder

Molecular weight: 168.62

Ref: 7W-GX9281

Bupropion Impurity 14 (3'-Chloropropiophenone)

CAS: 34841-35-5

Formula: C₉H₉ClO

Color and Shape: White To Off-White Solid

Molecular weight: 168.62

Ref: 4Z-B-0545

3-Chloropropiophenone

Controlled Product

CAS: 34841-35-5

Formula: C₉H₉ClO

Color and Shape: Neat

Molecular weight: 168.6202

Ref: 86-MM0745.08

Bupropion Des-t-Butylamino Impurity

CAS: 34841-35-5

Formula: C₉H₉ClO

Molecular weight: 168.62

Ref: ST-EA-CP-B21009

3'-Chloropropiophenone

Controlled Product

CAS: 34841-35-5

Impurity Bupropion Des-t-Butylamino Impurity
Applications 3'-Chloropropiophenone is a reagent used in the vinylation, alkylation and dienylation of ketones. It is also used in the preparation of thizaine derivatives that show antibacterial activity.
References Li, H. et al.: J. Am. Chem. Soc., 127, 8355 (2005); Deepika, G. et al.: J. Pharm. Res., 5, 1105 (2012);

Formula: C₉H₉ClO

Color and Shape: Neat

Molecular weight: 168.6202

Ref: TR-C379845

3-Chloropropiophenone

CAS: 34841-35-5

Applications 3-Chloropropiophenone is an impurity of Fluoxetine (F597100).
References Wirth, D.D. et al.: Chromatographia, 46, 511 (1997); Lacroix, P.M. et al.: J. AOAC Int., 78, 334 (1995);

Formula: C₉H₉ClO

Color and Shape: Neat

Molecular weight: 168.6202

Ref: TR-C379770

3'-Chloropropiophenone

CAS: 34841-35-5

3'-Chloropropiophenone is a reagent that is used in the synthesis of maleates. It can be synthesized by reacting hydrochloric acid with 3-chloropropiophenone under conditions where the temperature is kept below 30°C, and the reaction time is limited to five hours. The functional theory behind this reaction involves thionyl chloride as an electrophile that reacts with 3-chloropropiophenone to produce a chloroformate. The chloroformate then reacts with magnesium metal to yield magnesium chloride and 3'-chloropropiophenone. This compound has been shown to have vibrational frequencies of 207, 233, and 240 cm-1. 3'-Chloropropiophenone has also been shown to react with acetonitrile or methylene chloride to form chlorides or isopropyl chloride.

Formula: C₉H₉ClO

Purity: Min. 97.5 Area-%

Color and Shape: Powder

Molecular weight: 168.62 g/mol

Ref: 3D-FC38701

3′-Chloropropiophenone

CAS: 34841-35-5

Formula: C₉H₉ClO

Purity: 98%

Color and Shape: Solid

Molecular weight: 168.62

Ref: 10-F003621

3-Chloropropiophenone pure, 98%

CAS: 34841-35-5

Formula: C₉H₉OCl

Purity: min.98%

Color and Shape: White, Crystalline compound

Molecular weight: 168.62

Ref: SR-70774