CAS 353519-63-8

Formula: C25H25N3O2

InChI: InChI=1S/C25H25N3O2/c1-4-30-21-13-11-19(15-16(21)2)23(28-22-7-5-6-14-26-22)20-12-10-18-9-8-17(3)27-24(18)25(20)29/h5-15,23,29H,4H2,1-3H3,(H,26,28)

InChI key: CYNZBLNMIJNBSF-UHFFFAOYSA-N

SMILES: CCOC1=C(C=C(C=C1)C(C2=C(C3=C(C=CC(=N3)C)C=C2)O)NC4=CC=CC=N4)C

HLM006474

CAS: 353519-63-8

HLM006474 is a pan inhibitor of E2F. This inhibits E2F4 DNA-binding (IC50: 29.8 μM in A375 cells).

Formula: C₂₅H₂₅N₃O₂

Purity: 99.20% - 99.38%

Color and Shape: Solid

Molecular weight: 399.4849

Ref: TM-T15486

7-((4-Ethoxy-3-Methylphenyl)(2-Pyridylamino)Methyl)-2-Methyl-Quinolinol

CAS: 353519-63-8

7-((4-Ethoxy-3-Methylphenyl)(2-Pyridylamino)Methyl)-2-Methyl-Quinolinol

Formula: C₂₅H₂₅N₃O₂

Purity: >98%

Molecular weight: 399.48

Ref: 54-OR1024132

HLM006474

CAS: 353519-63-8

HLM006474

Formula: C₂₅H₂₅N₃O₂

Purity: ≥98%

Molecular weight: 399.48

Ref: 54-BUP09801

HLM 006474

CAS: 353519-63-8

Formula: C₂₅H₂₅N₃O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 399.4849

Ref: IN-DA00C6FT

HLM006474

CAS: 353519-63-8

7-((4-Ethoxy-3-methylphenyl)(pyridin-2-ylamino)methyl)-2-methylquinolin-8-ol

Formula: C₂₅H₂₅N₃O₂

Purity: 98+%

Molecular weight: 399.48

Ref: IN-DG395935

E2F Inhibitor, HLM006474

CAS: 353519-63-8

HLM006474 is a small molecule inhibitor of the E2F transcription factor. HLM006474 binds to the E2F protein and prevents it from binding to DNA, thereby inhibiting transcriptional regulation. This drug has been shown to be effective in animal models of cancer, hepatic steatosis, and diabetes. HLM006474 also inhibits CDK4/6-mediated phosphorylation of retinoblastoma protein (pRB), leading to inhibition of cell proliferation and tumor growth. These effects are accompanied by decreased levels of insulin resistance and increased insulin sensitivity in diabetic patients.

Formula: C₂₅H₂₅N₃O₂

Purity: Min. 95%

Molecular weight: 399.48 g/mol

Ref: 3D-DPA51963