CAS 35457-80-8

Midecamycin A1

Description:

Midecamycin A1 is a macrolide antibiotic that is derived from the fermentation of the bacterium Streptomyces. It is characterized by its complex structure, which includes a large lactone ring and multiple functional groups that contribute to its biological activity. Midecamycin A1 exhibits antibacterial properties, particularly against Gram-positive bacteria, making it useful in treating various infections. The compound is known for its mechanism of action, which involves inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit. This interference disrupts the translation process, ultimately leading to the cessation of bacterial growth. Midecamycin A1 is typically administered in its salt form and is often used in veterinary medicine as well as in human medicine for specific indications. Its pharmacokinetics include good absorption and distribution in tissues, although it may be subject to metabolism and excretion through hepatic pathways. As with many antibiotics, the potential for resistance development is a concern, necessitating careful use and monitoring in clinical settings.

Formula: C₄₁H₆₇NO₁₅

InChI: InChI=1S/C41H67NO15/c1-11-30(45)54-29-21-32(47)51-24(4)16-14-13-15-17-28(44)23(3)20-27(18-19-43)37(38(29)50-10)57-40-35(48)34(42(8)9)36(25(5)53-40)56-33-22-41(7,49)39(26(6)52-33)55-31(46)12-2/h13-15,17,19,23-29,33-40,44,48-49H,11-12,16,18,20-22H2,1-10H3/b14-13+,17-15+/t23-,24-,25-,26+,27+,28+,29-,33+,34-,35-,36-,37+,38+,39+,40+,41-/m1/s1

InChI key: InChIKey=DMUAPQTXSSNEDD-QALJCMCCSA-N

SMILES: O([C@@H]1[C@@H](OC)[C@H](OC(CC)=O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@@H]1CC=O)[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(CC)=O)[C@H](C)O3)[C@@H](C)O2

Synonyms:

• (4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-4-(Dimethylamino)-3-hydroxy-5-{[(2S,4R,5S,6S)-4-hydroxy-4,6-dimethyl-5-(propionyloxy)tetrahydro-2H-pyran-2-yl]oxy}-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-4-yl propanoate (non-preferred name)
• (4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-4-(dimethylamino)-3-hydroxy-5-{[(2S,4R,5S,6S)-4-hydroxy-4,6-dimethyl-5-(propanoyloxy)tetrahydro-2H-pyran-2-yl]oxy}-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-4-yl propanoate (non-preferred name)
• 252-578-0
• Aboren
• Antibiotic SF 837
• Antibiotic SF 837A₁
• Antibiotic YL 704B1
• Antibiotic YL 704B₁
• De 4',4''-Dipropionate (Ester)
• Espinomycin A
• Leucomycin V 3,4B-Dipropanoate
• Leucomycin V, 3,4^B-dipropanoate
• Macro-Dil
• Macropen
• Medecamycin A₁
• Medemycin A₁
• Midecamycin
• Midecamycin A₁
• Midecin
• Momicine
• Mydecamycin
• Mydecamycin A₁
• Myoxam
• NSC 154011
• Normicina
• Oxacyclohexadecane, leucomycin V deriv.
• Platenomycin B₁
• Rubimycin
• SF 837A₁
• Sf 837
• Turimycin P₃

Midecamycin, 900μg/mg

CAS: 35457-80-8

A broad spectrum antibiotic

Formula: C₄₁H₆₇NO₁₅

Molecular weight: 813.97

Ref: 02-J66046

Midecamycin

CAS: 35457-80-8

Formula: C₄₁H₆₇NO₁₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 813.9684

Ref: IN-DA007BW7

Midecamycin

CAS: 35457-80-8

Ref: 7W-GA6467

Midecamycin

CAS: 35457-80-8

Midecamycin

Purity: ≥95%

Molecular weight: 813.97g/mol

Ref: 54-BUP13931

Midecamycin

CAS: 35457-80-8

Midecamycin, a macrolide antibiotic, treats both gram-positive and gram-negative bacteria by blocking protein synthesis.

Formula: C₄₁H₆₇NO₁₅

Purity: 98.84%

Color and Shape: Solid

Molecular weight: 813.97

Ref: TM-T5037

Midecamycin

CAS: 35457-80-8

Applications A 16-membered ring macrolide antibiotic used in ophthalmology as well as other medical fields.
References Matsui, K. et al.: J. Inter. Cytokin Res., 24, 197 (2004); Schmalreck, A.F. et al.: Antiinfect Drugs Chemother., 14, 225 (1996); Tokuda, H. et al.: Chemother., 21, 887 (1973);

Formula: C₄₁H₆₇NO₁₅

Purity: >85%

Color and Shape: Off-White

Molecular weight: 813.97

Ref: TR-M343250

Midecamycin

CAS: 35457-80-8

Midecamycin is a macrolide antibiotic with action on bacterial protein synthesis by binding to the 50S ribosomal subunit and is used for treating respiratory tract and skin infections.

Formula: C₄₁H₆₇NO₁₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 813.97 g/mol

Ref: 3D-AM16806