CAS 355841-11-1

Desbutyllumefantrine

Description:

Desbutyllumefantrine is a chemical compound that serves as a metabolite of lumefantrine, which is primarily used in the treatment of malaria. It is characterized by its structural similarity to lumefantrine, featuring a complex arrangement of aromatic rings and aliphatic chains. The compound exhibits antimalarial properties, contributing to the overall efficacy of lumefantrine in combating Plasmodium species. Desbutyllumefantrine is typically analyzed in pharmacokinetic studies to understand its role in the metabolism and therapeutic effects of lumefantrine. Its solubility and stability in various solvents can influence its bioavailability and interaction with biological systems. Additionally, the compound's safety profile and potential side effects are important considerations in clinical settings. As a metabolite, it may also provide insights into the metabolic pathways involved in drug processing and the development of resistance in malaria parasites. Overall, desbutyllumefantrine plays a significant role in the pharmacological landscape of antimalarial therapies.

Formula: C₂₆H₂₄Cl₃NO

InChI: InChI=1/C26H24Cl3NO/c1-2-3-10-30-15-25(31)24-14-19(29)13-23-21(11-16-4-6-17(27)7-5-16)22-12-18(28)8-9-20(22)26(23)24/h4-9,11-14,25,30-31H,2-3,10,15H2,1H3/b21-11-

InChI key: InChIKey=YLBUTQNEBVPTES-NHDPSOOVNA-N

SMILES: C(CNCCCC)(O)C1=C2C(/C(=C\C3=CC=C(Cl)C=C3)/C=4C2=CC=C(Cl)C4)=CC(Cl)=C1

Synonyms:

• (9Z)-α-[(Butylamino)methyl]-2,7-dichloro-9-[(4-chlorophenyl)methylene]-9H-fluorene-4-methanol
• Desbutyl-benflumetol
• Desbutyllumefantrine
• 9H-Fluorene-4-methanol, α-[(butylamino)methyl]-2,7-dichloro-9-[(4-chlorophenyl)methylene]-, (9Z)-

Desbutyl Lumefantrine

CAS: 355841-11-1

Desbutyl Lumefantrine is a metabolite of lumefantrine with antimalarial activity.

Formula: C₂₆H₂₄Cl₃NO

Purity: 98%

Color and Shape: Solid

Molecular weight: 472.83

Ref: TM-T10999

Desbutyl Lumefantrine

CAS: 355841-11-1

Formula: C₂₆H₂₄Cl₃NO

Color and Shape: Pale Yellow Solid

Molecular weight: 472.85

Ref: 4Z-L-294

Desbutyl Lumefantrine HCl

CAS: 355841-11-1

Formula: C₂₆H₂₄Cl₃NO·HCl

Color and Shape: Yellow Solid

Molecular weight: 472.83 36.46

Ref: 4Z-L-2923

Desbutyl Lumefantrine-d9

CAS: 1346606-35-6, 355841-11-1

Formula: C₂₆H₁₅D₉Cl₃NO

Color and Shape: Yellow Solid

Molecular weight: 481.89

Ref: 4Z-L-2913

(Z)-Desbutyl Lumefantrine

Controlled Product

CAS: 355841-11-1

Stability Light Sensitive
Applications (Z)-Desbutyl Lumefantrine is a metabolite of Lumefantrine (L474000).
References Lefevre, G., et al.: Br. J. Clin. Pharmacol., 54, 485 (2002); Schepers, U., et al.: J. Pharm. Biomed. Anal., 310 (2005)

Formula: C₂₆H₂₄Cl₃NO

Color and Shape: Neat

Molecular weight: 472.83

Ref: TR-D289345

Desbutyl Lumefantrine Impurity

CAS: 355841-11-1

Formula: C₂₆H₂₄Cl₃NO

Molecular weight: 472.83

Ref: ST-EA-CP-L44005

(Z)-Desbutyl lumefantrine

CAS: 355841-11-1

(Z)-Desbutyl lumefantrine (DBL) is a drug used for the treatment and prevention of malaria. The drug is a prodrug that is converted to lumefantrine in vivo. DBL has significant interactions with other drugs, such as trifluoroacetic acid, which may lead to toxic effects or therapeutic failure. DBL should not be taken by nonpregnant women or women who are pregnant, as it can cause birth defects in the fetus. Pharmacokinetics of DBL were studied in healthy adult subjects and found to have linear pharmacokinetic properties in the concentration-time curve. It had a mean elimination half-life of 5 hours, an oral bioavailability of 98%, and low systemic clearance (0.2 L/h).

Formula: C₂₆H₂₄Cl₃NO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 472.8 g/mol

Ref: 3D-FPA84111