CAS 356057-34-6

Darapladib

Description:

Darapladib is a small molecule inhibitor primarily designed to target lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme implicated in atherosclerosis and cardiovascular diseases. Its chemical structure features a unique combination of functional groups that contribute to its biological activity. Darapladib is characterized by its ability to reduce inflammation and plaque formation in arterial walls, making it a candidate for therapeutic intervention in cardiovascular conditions. The substance is typically administered orally and has undergone various clinical trials to evaluate its efficacy and safety profile. Its pharmacokinetics indicate a moderate half-life, allowing for once-daily dosing in some studies. While promising, the clinical outcomes have shown mixed results, leading to ongoing research to better understand its role in cardiovascular therapy. As with many pharmaceuticals, potential side effects and interactions with other medications are important considerations in its use. Overall, Darapladib represents a significant area of interest in the development of treatments aimed at reducing cardiovascular risk.

Formula: C₃₆H₃₈F₄N₄O₂S

InChI: InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3

InChI key: InChIKey=WDPFJWLDPVQCAJ-UHFFFAOYSA-N

SMILES: C(C(N(CC1=CC=C(C=C1)C2=CC=C(C(F)(F)F)C=C2)CCN(CC)CC)=O)N3C4=C(C(=O)N=C3SCC5=CC=C(F)C=C5)CCC4

Synonyms:

• 1-[[[N-[2-(Diethylamino)ethyl]-N-[4-[4-(trifluoromethyl)phenyl]benzyl]amino]carbonyl]methyl]-2-(4-fluorobenzylthio)-5,6-trimethylenepyrimidin-4-one
• 1H-Cyclopentapyrimidine-1-acetamide, N-[2-(diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]methyl]-
• 480848
• Darapladib
• Darapladib (SB-480848)
• N-[2-(Diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]methyl]-1H-cyclopentapyrimidine-1-acetamide
• N-[2-(diethylamino)ethyl]-2-{2-[(4-fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}-N-{[4'-(trifluoromethyl)biphenyl-4-yl]methyl}acetamide
• Sb 435445
• Sb-480848
• N-(2-(Diethylamino)ethyl)-2-(2-((4-fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)-N-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)acetamide
• Darapladib API
• N-[2-(Diethylamino)ethyl]-N-[4'-(trifluoromethyl)-1,1'-biphenyl-4-ylmethyl]-2-[2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl]acetamide

Darapladib

CAS: 356057-34-6

Formula: C₃₆H₃₈F₄N₄O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 666.7711

Ref: IN-DA003P8R

Darapladib

CAS: 356057-34-6

N-(2-(Diethylamino)ethyl)-2-(2-((4-fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)-N-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)acetamide

Formula: C₃₆H₃₈F₄N₄O₂S

Purity: 98%

Molecular weight: 666.77

Ref: IN-DG301648

Darapladib

CAS: 356057-34-6

Darapladib

Formula: C₃₆H₃₈F₄N₄O₂S

Purity: ≥98%

Molecular weight: 666.77

Ref: 54-BUP15066

Darapladib

CAS: 356057-34-6

Darapladib (SB-480848) is a lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with an IC50 value of 0.25 nM.Cost-effective and quality-assured.

Formula: C₃₆H₃₈F₄N₄O₂S

Purity: 99.82% - >99.99%

Color and Shape: Solid

Molecular weight: 666.77

Ref: TM-T6109

Darapladib

CAS: 356057-34-6

Inhibitor of lipoprotein-associated phospholipase A2

Formula: C₃₆H₃₈F₄N₄O₂S

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 666.77 g/mol

Ref: 3D-FD158540

Darapladib - Bio-X ™

CAS: 356057-34-6

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₃₆H₃₈F₄N₄O₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 666.77 g/mol

Ref: 3D-BD300064

DARAPLADIB

CAS: 356057-34-6

Purity: 98%

Molecular weight: 666.7800293

Ref: 10-F793595