CAS 36396-99-3

N6-cyclohexyladenosine

Description:

N6-cyclohexyladenosine (CAS 36396-99-3) is a synthetic derivative of adenosine, characterized by the presence of a cyclohexyl group at the nitrogen atom in the N6 position of the adenine moiety. This modification enhances its affinity for adenosine receptors, particularly the A1 and A2A subtypes, making it a valuable compound in pharmacological research. N6-cyclohexyladenosine exhibits properties such as anti-inflammatory effects and potential neuroprotective benefits, which are of interest in the study of various diseases, including neurodegenerative disorders. The compound is typically soluble in organic solvents and may have limited solubility in water, which is common for many adenosine analogs. Its structural modifications contribute to altered pharmacokinetics and pharmacodynamics compared to natural adenosine, allowing for the exploration of therapeutic applications. As with many chemical substances, safety and handling precautions should be observed, particularly in laboratory settings. Overall, N6-cyclohexyladenosine serves as an important tool in understanding adenosine receptor biology and developing new therapeutic agents.

Formula: C₁₆H₂₃N₅O₄

InChI: InChI=1/C16H23N5O4/c22-6-10-12(23)13(24)16(25-10)21-8-19-11-14(17-7-18-15(11)21)20-9-4-2-1-3-5-9/h7-10,12-13,16,22-24H,1-6H2,(H,17,18,20)/t10-,12-,13-,16-/m1/s1

SMILES: C1CCC(CC1)Nc1c2c(ncn1)n(cn2)[C@H]1[C@@H]([C@@H]([C@@H](CO)O1)O)O

Synonyms:

• Adenosine, N(6)-Cyclohexyl-
• (4xi)-N-cyclohexyladenosine
• N-cyclohexyladenosine

N6-Cyclohexyladenosine

CAS: 36396-99-3

N6-Cyclohexyladenosine (CHA) is a selective agonist of A1 receptor with EC50 of 8.2 Nm.

Formula: C₁₆H₂₃N₅O₄

Purity: 99.92% - 99.98%

Color and Shape: Solid

Molecular weight: 349.38

Ref: TM-T12160

N6-CYCLOHEXYLADENOSINE

CAS: 36396-99-3

Formula: C₁₆H₂₃N₅O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 349.3849

Ref: IN-DA00C67W

N6-Cyclohexyladenosine

CAS: 36396-99-3

N6-Cyclohexyladenosine

Purity: ≥98%

Molecular weight: 349.38g/mol

Ref: 54-BUP13744

N6-Cyclohexyladenosine

CAS: 36396-99-3

Formula: C₁₆H₂₃N₅O₄

Molecular weight: 349.38

Ref: 7W-GL9473

N6-Cyclohexyladenosine

CAS: 36396-99-3

N6-Cyclohexyladenosine

Purity: 98%

Molecular weight: 349.38g/mol

Ref: 54-OR1026351

N6-Cyclohexyladenosine

Controlled Product

CAS: 36396-99-3

Stability Hygroscopic
Applications N6-Cyclohexyladenosine is a derivative of Adenosine (A280400), and is used testing adenosine A1 and A2A receptor activation for pharmaceuticals such as antidepressants. N6-Cyclohexyladenosine also is used as a JAK2 inhibitor, blocking STAT3 signalling in human cancer cells.
References Liu, P. et al.: Cancer Lett., 354, 43 (2014); Cunha, M. et al.: Purinerg. Signal., 11, 215 (2015);

Formula: C₁₆H₂₃N₅O₄

Color and Shape: Neat

Molecular weight: 349.38

Ref: TR-C989785