CAS 364-98-7

Diazoxide

Description:

Diazoxide is a pharmaceutical compound primarily used as an antihypertensive agent and in the management of hypoglycemia. It is classified as a thiazide derivative and functions by relaxing vascular smooth muscle, leading to vasodilation and a subsequent decrease in blood pressure. The chemical structure of diazoxide includes a diazine ring, which contributes to its pharmacological properties. It is typically administered orally and has a relatively long half-life, allowing for sustained effects. Diazoxide is also known for its ability to inhibit insulin secretion from the pancreas, making it useful in specific clinical scenarios, such as in patients with insulinoma or other conditions associated with excessive insulin production. The compound is generally well-tolerated, but it may cause side effects such as fluid retention, tachycardia, and hyperglycemia. Due to its potent effects, diazoxide is usually prescribed under careful medical supervision, particularly in patients with cardiovascular issues. Its CAS number, 364-98-7, is used for identification in chemical databases and regulatory contexts.

Formula: C₈H₇ClN₂O₂S

InChI: InChI=1/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11,12,13)

InChI key: InChIKey=GDLBFKVLRPITMI-UHFFFAOYSA-N

SMILES: O=S1(=O)C=2C(NC(C)=N1)=CC=C(Cl)C2

Synonyms:

• 2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide
• 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide
• 4H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide
• 7-Chloro-3-Methyl-1Lambda~4~,2,4-Benzothiadiazin-1-Ol 1-Oxide
• 7-Chloro-3-methyl-2H-benzo[1,2,4]thiadiazine 1,1-dioxide
• 7-Chloro-3-methyl-4H-benzo[1,2,4]thiadiazine 1,1-dioxide
• 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
• 7-chloro-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide
• Diazoxid
• Diazoxido
• Dizoxide
• Eudemine injection
• Hyperstat
• Hypertonalum
• Mutabase
• Nsc 64198
• Nsc 76130
• Proglicem
• Proglycem
• Sch 6783
• Srg 95213
• Diazoxide
• DIAZOXIDE 364-98-7 kf-wang(at)kf-chem.com
• DIAZOXIDE ACTIVATOR OF ATP-DEPE
• 7-chloro-3-methyl-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide
• Diazoxide Benzothiadiazinone Analog
• 7-cloro-3-metil-2h-1,2,4-benzotiodiazina-1,1-diossido
• Diazoxide (200 mg)
• Desipramine Impurity 7
• 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine1
• Diazoxide-13CD3
• Diazoxide API
• Diazoxide,7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
• Diazoxide impurity-4 (7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide)
• Diazoxide CRS
• DIAZOXIDE,USP
• 7-chloro-3-methyl-4H-1λ,2,4-benzothiadiazine-1,1-dione
• Diazoxided
• DIAZOXIDE USP/EP/BP
• srg95213
• Eudemine
• Diazoxide (1186000)
• 7-chloro-3-methyl-4h-1λ6,2,4-benzothiadiazine 1,1-dioxide

Diazoxide

CAS: 364-98-7

Color and Shape: Neat

Ref: 61-FOR3038.00

DIAZOXIDE CRS

CAS: 364-98-7

DIAZOXIDE CRS

Formula: C₈H₇ClN₂O₂S

Color and Shape: Crystalline Powder. White. Whitish. Powder.

Molecular weight: 230.6714

Ref: 41-D0950000

Diazoxide

CAS: 364-98-7

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₈H₇ClN₂O₂S

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 229.99168

Ref: 45-1186000

DIAZOXIDE

CAS: 364-98-7

Formula: C₈H₇ClN₂O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 230.6714

Ref: IN-DA0039DY

Diazoxide

CAS: 364-98-7

Diazoxide (Proglycem) is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies.

Formula: C₈H₇ClN₂O₂S

Purity: 99% - 99.83%

Color and Shape: Solid

Molecular weight: 230.67

Ref: TM-T0126

Diazoxide

CAS: 364-98-7

Formula: C₈H₇ClN₂O₂S

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 230.67

Ref: 7W-GP7721

Diazoxide

CAS: 364-98-7

Diazoxide

Purity: ≥98%

Molecular weight: 230.67g/mol

Ref: 54-BUP16547

Diazoxide

CAS: 364-98-7

Diazoxide

Purity: 98%

Molecular weight: 230.67g/mol

Ref: 54-OR1012812

Diazoxide

CAS: 364-98-7

Formula: C₈H₇ClN₂O₂S

Molecular weight: 230.67

Ref: 4Z-D-431

Diazoxide

CAS: 364-98-7

Formula: C₈H₇ClN₂O₂S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 230.67

Ref: 3B-D5402

Diazoxide

CAS: 364-98-7

Formula: C₈H₇ClN₂O₂S

Color and Shape: Off White Crystalline

Molecular weight: 230.67

Ref: 86-MM3038.00

Diazoxide-d6

CAS: 364-98-7

Formula: C₈HD₆ClN₂O₂S

Molecular weight: 236.70

Ref: 4Z-D-435

Diazoxide

Controlled Product

CAS: 364-98-7

Applications Diazoxide reduces status epilepticus neuron damage in diabetes. A potassium channel opener
References Baba, A., et al.: J. Neurosci., 23, 7737 (2003), Bancila, V., et al.: J. Neurochem., 90, 1243 (2004), Bancila, V., et al.: J. Biol. Chem., 280, 8793 (2005),

Formula: C₈H₇ClN₂O₂S

Color and Shape: Neat

Molecular weight: 230.67

Ref: TR-D417305

Diazoxide

CAS: 364-98-7

Formula: C₈H₇ClN₂O₂S

Purity: 95%

Color and Shape: Solid

Molecular weight: 230.67

Ref: 10-F047209

Diazoxide

CAS: 364-98-7

Formula: C₈H₇ClN₂O₂S

Molecular weight: 230.67

Ref: ST-EA-CP-D213000

Diazoxide

CAS: 364-98-7

Diazoxide is a drug that belongs to the class of pharmacological agents. It is used as a primary pulmonary hypertension treatment. Diazoxide is an uncoupler of oxidative phosphorylation and it also acts on mitochondria in the cells. Diazoxide has been shown to decrease insulin levels in maternal blood, which may be due to its ability to inhibit insulin release from pancreatic beta cells. This drug also has antioxidant properties, which may be due to its ability to reduce lipid peroxidation and protein oxidation. Diazoxide has been shown to have beneficial effects for bowel diseases such as ulcerative colitis and Crohn's disease, due to its antioxidant properties and its ability to inhibit oxidative injury in the gut wall. Diazoxide inhibits channels that are involved in neuronal death, which is associated with stroke-induced brain damage.

Formula: C₈H₇ClN₂O₂S

Purity: Min. 97 Area-%

Color and Shape: White To Off-White To Grey Solid

Molecular weight: 230.67 g/mol

Ref: 3D-FD21519