CAS 364782-34-3

Cinacalcet hydrochloride

Description:

Cinacalcet hydrochloride is a synthetic compound primarily used as a medication to manage secondary hyperparathyroidism in patients with chronic kidney disease and to treat hypercalcemia in patients with parathyroid carcinoma. It functions as a calcimimetic agent, which means it enhances the sensitivity of calcium-sensing receptors on parathyroid cells, leading to decreased parathyroid hormone (PTH) secretion and subsequently lowering serum calcium levels. The substance is typically administered orally and is characterized by its white to off-white crystalline powder form. Its solubility profile indicates that it is soluble in water and methanol, which facilitates its absorption in the gastrointestinal tract. The molecular formula of cinacalcet hydrochloride reflects its complex structure, which includes multiple functional groups that contribute to its pharmacological activity. As with many medications, it is essential to monitor for potential side effects, including nausea, vomiting, and hypocalcemia, during treatment. Overall, cinacalcet hydrochloride plays a significant role in managing calcium homeostasis in specific patient populations.

Formula: C₂₂H₂₂F₃N·ClH

InChI: InChI=1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1

InChI key: InChIKey=QANQWUQOEJZMLL-PKLMIRHRSA-N

SMILES: [C@@H](NCCCC1=CC(C(F)(F)F)=CC=C1)(C)C=2C3=C(C=CC2)C=CC=C3.Cl

Synonyms:

• 1-Naphthalenemethanamine, α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, hydrochloride (1:1), (αR)-
• 1-Naphthalenemethanamine, α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, hydrochloride, (αR)-
• AMG 073 HCl
• Cinacalcet HCl
• Krn 1493
• Mimpara
• N-((1R)-1-(1-Naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride
• Regpara
• Sensipar
• [(1R)-1-(Naphthalen-1-yl)ethyl]([3-[3-(trifluoromethyl)phenyl]propyl])amine hydrochloride
• Cinacalcet hydrochloride

Cinacalcet Hydrochloride

CAS: 364782-34-3

Formula: C₂₂H₂₂F₃N·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 393.88

Ref: 3B-C3833

Cinacalcet Hydrochloride

CAS: 364782-34-3

Color and Shape: White To Beige

Ref: 61-FOR3370.00

Cinacalcet Hydrochloride (N-[(1R)-1-(Naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride)

CAS: 364782-34-3

Aromatic monoamines and their derivatives, salts thereof, nesoi

Formula: C₂₂H₂₂F₃N·HCl

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 393.14711

Ref: 45-1133977

Cinacalcet hydrochloride

CAS: 364782-34-3

Cinacalcet hydrochloride

Formula: C₂₂H₂₂F₃N·ClH

Purity: 99%

Color and Shape: Solid-Powder

Molecular weight: 393.87292

Ref: 54-PC301203

Cinacalcet, HCl

CAS: 364782-34-3

Formula: C₂₂H₂₃ClF₃N

Purity: 98%

Color and Shape: Solid

Molecular weight: 393.8729

Ref: IN-DA00I787

Cinacalcet HCl

CAS: 364782-34-3

Formula: C₂₂H₂₂F₃N·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 357.42 36.46

Ref: 4Z-C-401

Cinacalcet hydrochloride

CAS: 364782-34-3

Cinacalcet hydrochloride

Formula: C₂₂H₂₃ClF₃N

Purity: ≥98%

Molecular weight: 393.87

Ref: 54-BUP15696

Cinacalcet Hydrochloride

Controlled Product

CAS: 364782-34-3

Formula: C₂₂H₂₂F₃N·ClH

Color and Shape: Neat

Molecular weight: 393.87

Ref: 86-MM3370.00

Cinacalcet hydrochloride

CAS: 364782-34-3

Cinacalcet hydrochloride (AMG-073 hydrochloride) is a naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-

Formula: C₂₂H₂₃ClF₃N

Purity: 99.96% - >99.99%

Color and Shape: Off-White To Tan Solid

Molecular weight: 393.87

Ref: TM-T2406

Cinacalcet

CAS: 364782-34-3

Formula: C₂₂H₂₂F₃NHCl

Molecular weight: 357.4 : 36.5

Ref: ST-EA-CP-C21000

Cinacalcet Hydrochloride

Controlled Product

CAS: 364782-34-3

Formula: C₂₂H₂₂F₃N·ClH

Color and Shape: Neat

Molecular weight: 393.87

Ref: TR-C441800

Cinacalcet-d4 Hydrochloride

Controlled Product

CAS: 364782-34-3

Applications Cinacalcet-d4 Hydrochloride is a labeled analogue of Cinacalcet Hydrochloride (C441800), the (R) enantiomer of Cinacalcet which is used in clinical trial in secondary hyperparathyroidism.
References Franceschini N., et al.: Expert Opin. Invest. Drugs, 12, 1413 (2003); Block, G.A., et al.: N. Engl. J. Med. 350, 1516 (2004);

Formula: C₂₂H₁₉D₄ClF₃N

Color and Shape: Neat

Molecular weight: 397.9

Ref: TR-C441803

N-[1-(R)-(-)-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane hydrochloride

CAS: 364782-34-3

N-[1-(R)-(-)-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane hydrochloride is a synthetic compound that is used for the treatment of hyperparathyroidism. It inhibits parathyroid hormone (PTH) synthesis by inhibiting the enzyme responsible for PTH synthesis, which is called adenyl cyclase. This drug also binds to calcium ions and inhibits their release from bones and teeth. N-[1-(R)-(-)-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane hydrochloride has been shown to be effective in treating skin cancer in animal models. It has also been shown to have a reaction mechanism in which it binds to DNA, preventing transcription and replication through inhibition of RNA polymerase. The clinical significance of this drug as a potential biomark

Formula: C₂₂H₂₂F₃N·HCl

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 393.87 g/mol

Ref: 3D-IN58180

Cinacalcet HCl

CAS: 364782-34-3

(R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride

Formula: C₂₂H₂₃ClF₃N

Purity: 98%

Molecular weight: 393.87

Ref: IN-DG213065

(R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride

CAS: 364782-34-3

Formula: C₂₂H₂₃ClF₃N

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 393.88

Ref: 10-F079280