CAS 36507-30-9

Carbamazepine 10,11-epoxide

Description:

Carbamazepine 10,11-epoxide is a pharmacologically active metabolite of carbamazepine, primarily known for its role in the treatment of epilepsy and bipolar disorder. This compound is characterized by its epoxide functional group, which contributes to its reactivity and biological activity. It typically appears as a white to off-white solid and is soluble in organic solvents. The molecular structure includes a dibenzazepine core, which is essential for its therapeutic effects. The compound exhibits anticonvulsant properties and is believed to modulate sodium channels, thereby stabilizing neuronal membranes. Additionally, it has been studied for its potential role in drug interactions and toxicity, particularly in relation to its metabolic pathways. Due to its epoxide nature, it can also participate in further chemical reactions, which may influence its pharmacokinetics and pharmacodynamics. As with many pharmaceuticals, the safety profile and side effects are important considerations in its clinical use. Overall, Carbamazepine 10,11-epoxide is a significant compound in neuropharmacology, contributing to the efficacy of carbamazepine therapy.

Formula: C₁₅H₁₂N₂O₂

InChI: InChI=1S/C15H12N2O2/c16-15(18)17-11-7-3-1-5-9(11)13-14(19-13)10-6-2-4-8-12(10)17/h1-8,13-14H,(H2,16,18)

InChI key: InChIKey=ZRWWEEVEIOGMMT-UHFFFAOYSA-N

SMILES: C(N)(=O)N1C=2C(C3C(O3)C=4C1=CC=CC4)=CC=CC2

Synonyms:

• 10,11-Dihydro-10,11-epoxycarbamazepine
• 10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide 10,11-epoxide
• 10,11-Epoxycarbamazepine
• 1a,10b-Dihydro-6H-dibenz(b,f)oxiren(d)azepine-6-carboxamide
• 1a,10b-Dihydro-6H-dibenz[b,f]oxireno[d]azepine-6-carboxamide
• 1a,10b-dihydro-6H-dibenzo[b,f]oxireno[d]azepine-6-carboxamide
• 6H-Dibenz(b,f)oxiren(d)azepine-6-carboxamide, 1a,10b-dihydro-
• 6H-Dibenz[b,f]oxireno[d]azepine-6-carboxamide, 1a,10b-dihydro-
• Brn 1219988
• Carbamazepine 10,11-oxide
• Carbamazepine epoxide
• Carbamazepine-10,11-trans-dihydrodiol
• Gp 49-023
• Carbamazepine 10,11-epoxide
• Carbamazepine-10,11-epoxide

Carbamazepine 10,11-Epoxide

CAS: 36507-30-9

Formula: C₁₅H₁₂N₂O₂

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 252.27

Ref: 3B-D5982

Carbamazepine 10,11-Epoxide

CAS: 36507-30-9

Color and Shape: Neat

Ref: 61-FOR0076.01

Carbamazepine 10,11-Epoxide 1.0 mg/ml in Acetonitrile

CAS: 36507-30-9

Color and Shape: Single Solution

Ref: 61-AMP0076.01-11

1A,10B-DIHYDRO-6H-DIBENZO[B,F]OXIRENO[D]AZEPINE-6-CARBOXAMIDE

CAS: 36507-30-9

Formula: C₁₅H₁₂N₂O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 252.2680

Ref: IN-DA00BZEY

Carbamazepine 10,11-epoxide

CAS: 36507-30-9

Carbamazepine 10,11-epoxide

Purity: ≥98%

Molecular weight: 252.27g/mol

Ref: 54-BUP10628

Carbamazepine-10,11-Epoxide

CAS: 36507-30-9

Formula: C₁₅H₁₂N₂O₂

Color and Shape: White To Off-White Solid

Molecular weight: 252.27

Ref: 4Z-C-193

1AH-Dibenzo[B,F]Oxireno[2,3-D]Azepine-6(10Bh)-Carboxamide

CAS: 36507-30-9

1AH-Dibenzo[B,F]Oxireno[2,3-D]Azepine-6(10Bh)-Carboxamide

Purity: 98%

Molecular weight: 252.27g/mol

Ref: 54-OR1009348

Carbamazepine 10,11-epoxide 100 µg/mL in Acetonitrile

Controlled Product

CAS: 36507-30-9

Formula: C₁₅H₁₂N₂O₂

Color and Shape: Single Solution

Molecular weight: 252.27

Ref: 04-A10968550AL-100

Carbamazepin-10,11-epoxide

CAS: 36507-30-9

Formula: C₁₅H₁₂N₂O₂

Color and Shape: Neat

Molecular weight: 252.27

Ref: 04-C10968550

Carbamazepine 10,11-Epoxide

Controlled Product

CAS: 36507-30-9

Formula: C₁₅H₁₂N₂O₂

Color and Shape: Neat

Molecular weight: 252.27

Ref: 86-MM0076.01

Carbamazepine 10,11-epoxide

CAS: 36507-30-9

Carbamazepine 10,11-epoxide, an active metabolite with anticonvulsant properties, is created by CYP3A4 and CYP2C8.

Formula: C₁₅H₁₂N₂O₂

Purity: 98.64% - 99.75%

Color and Shape: Solid

Molecular weight: 252.27

Ref: TM-T37149

Tiocarbazil

CAS: 36507-30-9

Applications A metabolite of Carbamazepine (C175840).Representative lots contained 1-2% carbamazepine by HPLC.
References Bellucci, G., et al.: J. Med. Chem., 30, 768 (1987), Johannessen, S., et al.: Ther. Drug. Monit., 27, 710 (2005), Bialer, M., et al.: Expert Opin. Invest. Drugs, 15, 637 (2006), Williams, J., et al.: J. Clin. Pharmacol., 46, 258 (2006),

Formula: C₁₅H₁₂N₂O₂

Purity: >97% by HPLC

Color and Shape: Neat

Molecular weight: 252.27

Ref: TR-C175850

1A,10B-DIHYDRO-6H-DIBENZO[B,F]OXIRENO[D]AZEPINE-6-CARBOXAMIDE

CAS: 36507-30-9

Purity: 97.0%

Molecular weight: 252.273

Ref: 10-F386771

Carbamazepine 10,11-Epoxide-d8 (Major)

Controlled Product

CAS: 36507-30-9

Applications A labelled metabolite of Carbamazepine (C175840).
References Bellucci, G., et al.: J. Med. Chem., 30, 768 (1987), Johannessen, S., et al.: Ther. Drug. Monit., 27, 710 (2005), Bialer, M., et al.: Expert Opin. Invest. Drugs, 15, 637 (2006), Williams, J., et al.: J. Clin. Pharmacol., 46, 258 (2006),

Formula: C₁₅H₄D₈N₂O₂

Color and Shape: White To Dark Yellow

Molecular weight: 260.32

Ref: TR-C175854

Carbamazepine 10,11-epoxide

CAS: 36507-30-9

Inhibitor of neuronal voltage-gated sodium channels

Formula: C₁₅H₁₂N₂O₂

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 252.27 g/mol

Ref: 3D-FC19680

Carbamazepine 10,11-Epoxide

CAS: 36507-30-9

Formula: C₁₅H₁₂N₂O₂

Molecular weight: 252.27

Ref: ST-EA-CP-O13021