CAS 36507-30-9
:Carbamazepine 10,11-epoxide
Description:
Carbamazepine 10,11-epoxide is a pharmacologically active metabolite of carbamazepine, primarily known for its role in the treatment of epilepsy and bipolar disorder. This compound is characterized by its epoxide functional group, which contributes to its reactivity and biological activity. It typically appears as a white to off-white solid and is soluble in organic solvents. The molecular structure includes a dibenzazepine core, which is essential for its therapeutic effects. The compound exhibits anticonvulsant properties and is believed to modulate sodium channels, thereby stabilizing neuronal membranes. Additionally, it has been studied for its potential role in drug interactions and toxicity, particularly in relation to its metabolic pathways. Due to its epoxide nature, it can also participate in further chemical reactions, which may influence its pharmacokinetics and pharmacodynamics. As with many pharmaceuticals, the safety profile and side effects are important considerations in its clinical use. Overall, Carbamazepine 10,11-epoxide is a significant compound in neuropharmacology, contributing to the efficacy of carbamazepine therapy.
Formula:C15H12N2O2
InChI:InChI=1S/C15H12N2O2/c16-15(18)17-11-7-3-1-5-9(11)13-14(19-13)10-6-2-4-8-12(10)17/h1-8,13-14H,(H2,16,18)
InChI key:InChIKey=ZRWWEEVEIOGMMT-UHFFFAOYSA-N
SMILES:C(N)(=O)N1C=2C(C3C(O3)C=4C1=CC=CC4)=CC=CC2
Synonyms:- 10,11-Dihydro-10,11-epoxycarbamazepine
- 10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide 10,11-epoxide
- 10,11-Epoxycarbamazepine
- 1a,10b-Dihydro-6H-dibenz(b,f)oxiren(d)azepine-6-carboxamide
- 1a,10b-Dihydro-6H-dibenz[b,f]oxireno[d]azepine-6-carboxamide
- 1a,10b-dihydro-6H-dibenzo[b,f]oxireno[d]azepine-6-carboxamide
- 6H-Dibenz(b,f)oxiren(d)azepine-6-carboxamide, 1a,10b-dihydro-
- 6H-Dibenz[b,f]oxireno[d]azepine-6-carboxamide, 1a,10b-dihydro-
- Brn 1219988
- Carbamazepine 10,11-oxide
- Carbamazepine epoxide
- Carbamazepine-10,11-trans-dihydrodiol
- Gp 49-023
- Carbamazepine 10,11-epoxide
- Carbamazepine-10,11-epoxide
- See more synonyms
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Found 18 products.
Carbamazepine 10,11-Epoxide
CAS:Formula:C15H12N2O2Purity:>98.0%(HPLC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:252.271AH-Dibenzo[B,F]Oxireno[2,3-D]Azepine-6(10Bh)-Carboxamide
CAS:1AH-Dibenzo[B,F]Oxireno[2,3-D]Azepine-6(10Bh)-CarboxamideFormula:C15H12N2O2Purity:>98%Molecular weight:252.271A,10B-DIHYDRO-6H-DIBENZO[B,F]OXIRENO[D]AZEPINE-6-CARBOXAMIDE
CAS:Formula:C15H12N2O2Purity:97%Color and Shape:SolidMolecular weight:252.2680Carbamazepine 10,11-epoxide
CAS:Carbamazepine 10,11-epoxideFormula:C15H12N2O2Purity:≥98%Molecular weight:252.27Carbamazepine-10,11-Epoxide
CAS:Formula:C15H12N2O2Color and Shape:White To Off-White SolidMolecular weight:252.27Carbamazepine 10,11-epoxide 100 µg/mL in Acetonitrile
CAS:Controlled ProductFormula:C15H12N2O2Color and Shape:Single SolutionMolecular weight:252.27Carbamazepine 10,11-Epoxide
CAS:Controlled ProductFormula:C15H12N2O2Color and Shape:NeatMolecular weight:252.27Carbamazepine 10,11-epoxide (Standard)
CAS:Carbamazepine 10,11-epoxide (Standard) is a reference standard for research and analysis in studies involving Carbamazepine 10,11-epoxide. Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine[1][2].It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells expressing CYP3A4 or CYP2C8, respectively[1].Carbamazepine 10,11-epoxide has anticonvulsant activity against maximal electroshock-induced seizures in mice.2It has been found in wastewater effluent[3].Formula:C15H12N2O2Color and Shape:SolidMolecular weight:252.27Carbamazepine 10,11-epoxide
CAS:1aH-Dibenzo[b,f]oxireno[2,3-d]azepine-6(10bH)-carboxamideFormula:C15H12N2O2Purity:97%Molecular weight:252.27Carbamazepine 10,11-epoxide
CAS:Carbamazepine 10,11-epoxide, an active metabolite with anticonvulsant properties, is created by CYP3A4 and CYP2C8.Formula:C15H12N2O2Purity:98.64% - 99.75%Color and Shape:Yellow SolidMolecular weight:252.271A,10B-DIHYDRO-6H-DIBENZO[B,F]OXIRENO[D]AZEPINE-6-CARBOXAMIDE
CAS:Purity:97.0%Molecular weight:252.273Carbamazepine 10,11-Epoxide-d8 (Major)
CAS:Controlled ProductApplications A labelled metabolite of Carbamazepine (C175840).
References Bellucci, G., et al.: J. Med. Chem., 30, 768 (1987), Johannessen, S., et al.: Ther. Drug. Monit., 27, 710 (2005), Bialer, M., et al.: Expert Opin. Invest. Drugs, 15, 637 (2006), Williams, J., et al.: J. Clin. Pharmacol., 46, 258 (2006),Formula:C15H4D8N2O2Color and Shape:NeatMolecular weight:260.32Carbamazepine 10,11-Epoxide
CAS:Applications A metabolite of Carbamazepine (C175840).Representative lots contained 1-2% carbamazepine by HPLC.
References Bellucci, G., et al.: J. Med. Chem., 30, 768 (1987), Johannessen, S., et al.: Ther. Drug. Monit., 27, 710 (2005), Bialer, M., et al.: Expert Opin. Invest. Drugs, 15, 637 (2006), Williams, J., et al.: J. Clin. Pharmacol., 46, 258 (2006),Formula:C15H12N2O2Purity:>97% by HPLCColor and Shape:NeatMolecular weight:252.27Carbamazepine 10,11-epoxide
CAS:Inhibitor of neuronal voltage-gated sodium channels
Formula:C15H12N2O2Purity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:252.27 g/mol
![1A,10B-DIHYDRO-6H-DIBENZO[B,F]OXIRENO[D]AZEPINE-6-CARBOXAMIDE](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA00BZEY.jpg&w=3840&q=75)
![1A,10B-DIHYDRO-6H-DIBENZO[B,F]OXIRENO[D]AZEPINE-6-CARBOXAMIDE](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb%2FF386771.jpg&w=3840&q=75)
