CAS 366789-02-8
:Rivaroxaban
Description:
Rivaroxaban is an oral anticoagulant medication primarily used for the prevention and treatment of thromboembolic disorders, such as deep vein thrombosis and pulmonary embolism. It functions as a direct factor Xa inhibitor, which disrupts the coagulation cascade and reduces the formation of blood clots. Rivaroxaban is characterized by its high bioavailability and predictable pharmacokinetics, allowing for fixed dosing without the need for routine monitoring of coagulation parameters. The substance is typically administered in tablet form and is absorbed rapidly, with peak plasma concentrations occurring within a few hours post-ingestion. It is metabolized primarily in the liver through cytochrome P450 enzymes and is excreted via both renal and fecal pathways. Common side effects may include bleeding complications, which necessitate caution in patients with certain risk factors. Rivaroxaban's efficacy and safety profile have made it a widely used option in anticoagulation therapy, although it is contraindicated in patients with active bleeding or severe renal impairment.
Formula:C19H18ClN3O5S
InChI:InChI=1/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
InChI key:InChIKey=KGFYHTZWPPHNLQ-AWEZNQCLSA-N
SMILES:O=C1N(C[C@H](CNC(=O)C=2SC(Cl)=CC2)O1)C3=CC=C(C=C3)N4C(=O)COCC4
Synonyms:- (S)-Rivaroxaban
- 2-Thiophenecarboxamide, 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-
- 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide
- 5-Chloro-N-([(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl]-methyl)-2-thiophenecarboxamide
- 5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
- 5-Chloro-N-[[(S)-3-(4-(3-oxomorpholin-4-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]-thiophene-2-carboxamide
- 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl]thiophene-2-carboxamide
- Bay 59-7939
- Rivaroxaban intermediates
- Rivaroxban
- Xarelto
- Rivaroxaban
- (S)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
- Rivaroxaban API
- Rivarobaxan
- Rivaroxaban(Xarelto)
- (S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)thiophene-2-carboxami
- Rivaroxaba
- See more synonyms
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Rivaroxaban
CAS:Formula:C19H18ClN3O5SPurity:>98.0%(HPLC)(T)Color and Shape:White to Light yellow powder to crystalMolecular weight:435.88Rivaroxaban
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compoundsFormula:C19H18ClN3O5SColor and Shape:White PowderMolecular weight:435.06557Rivaroxaban
CAS:RivaroxabanFormula:C19H18ClN3O5SPurity:0.995Color and Shape:SolidMolecular weight:435.88Rivaroxaban
CAS:Rivaroxaban (BAY 59-7939) is an oral, direct factor Xa inhibitor with anticoagulant properties, interfering with thrombin formation.Formula:C19H18ClN3O5SPurity:99.93% - >99.99%Color and Shape:White SolidMolecular weight:435.88Ref: TM-T1184
2mg34.00€5mg54.00€1mL*10mM (DMSO)54.00€10mg65.00€25mg99.00€50mg112.00€100mg175.00€200mg250.00€Rivaroxaban
CAS:Formula:C19H18ClN3O5SPurity:≥ 98.0% (dried basis)Color and Shape:White to off-white powderMolecular weight:435.88Rivaroxaban (Standard)
CAS:Rivaroxaban (Standard) is a reference standard for research and analysis in studies involving Rivaroxaban. Rivaroxaban (BAY 59-7939) is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both free factor Xa and factor Xa bound in the prothrombinase complex. This interferes with the conversion of prothrombin (factor II) to thrombin and eventually prevents the formation of cross-linked fibrin clots. Rivaroxaban does not affect existing thrombin levels.Formula:C19H18ClN3O5SMolecular weight:435.88Rivaroxaban
CAS:Applications A novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.
References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),Formula:C19H18ClN3O5SColor and Shape:NeatMolecular weight:435.88(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
CAS:(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamideFormula:C19H18ClN3O5SPurity:98%Molecular weight:435.88Rivaroxaban
CAS:Rivaroxaban is a natural drug that is a direct factor Xa inhibitor. It has been shown to be an effective therapy for the treatment of atrial fibrillation, deep vein thrombosis (DVT) and pulmonary embolism (PE). It works by inhibiting the enzyme, thrombin, which is responsible for the formation of blood clots. Rivaroxaban also has an effect on the coagulation system by decreasing the levels of fibrinogen and increases in antithrombin III. This drug does not have any specific antidote, but it can be reversed with heparin. Pharmacodynamics and drug interactions have been studied extensively in preclinical models, demonstrated by the concentration–time curves.
Formula:C19H18ClN3O5SPurity:Min. 98 Area-%Color and Shape:White Off-White PowderMolecular weight:435.88 g/molRivaroxaban - Bio-X ™
CAS:Rivaroxaban is a natural drug that is a direct factor Xa inhibitor. It has been shown to be an effective therapy for the treatment of atrial fibrillation, deep vein thrombosis (DVT) and pulmonary embolism (PE). It works by inhibiting the enzyme, thrombin, which is responsible for the formation of blood clots. Rivaroxaban also has an effect on the coagulation system by decreasing the levels of fibrinogen and increases in antithrombin III. This drug does not have any specific antidote, but it can be reversed with heparin. Pharmacodynamics and drug interactions have been studied extensively in preclinical models, demonstrated by the concentration–time curves.Formula:C19H18ClN3O5SPurity:Min. 95%Color and Shape:PowderMolecular weight:435.88 g/mol5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide
CAS:Formula:C19H18ClN3O5SPurity:99%Color and Shape:SolidMolecular weight:435.8813
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