CAS 3737-09-5

Disopyramide

Description:

Disopyramide is a medication primarily used as an antiarrhythmic agent to treat certain types of irregular heartbeats, particularly ventricular arrhythmias. It belongs to the class of drugs known as sodium channel blockers, which work by inhibiting the influx of sodium ions during the cardiac action potential, thereby stabilizing the cardiac membrane and reducing excitability. Disopyramide is characterized by its chemical formula C20H24N2O, and it typically appears as a white to off-white crystalline powder. The substance is soluble in organic solvents such as ethanol and chloroform but has limited solubility in water. Its pharmacological effects include negative inotropic action, which can decrease myocardial contractility, and it may also have anticholinergic properties, leading to side effects such as dry mouth and urinary retention. Disopyramide is administered orally and is subject to careful monitoring due to potential side effects and interactions with other medications. As with any antiarrhythmic, its use requires consideration of the patient's overall health and specific cardiac conditions.

Formula: C₂₁H₂₉N₃O

InChI: InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)

InChI key: InChIKey=UVTNFZQICZKOEM-UHFFFAOYSA-N

SMILES: C(CCN(C(C)C)C(C)C)(C(N)=O)(C1=CC=CC=C1)C2=CC=CC=N2

Synonyms:

• (RS)-disopyramide
• 2-Pyridineacetamide, α-[2-(diisopropylamino)ethyl]-α-phenyl-
• 2-Pyridineacetamide, α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-
• 4-Diisopropylamino-2-phenyl-2-(2-pyridyl)butyramide
• Dicorantil
• Disopiramida
• Disopyramid
• Disopyramide
• H 3292
• Isorythm
• Lispine
• Ritmilen
• Ritmodan
• Sc 7031
• Searle 703
• dl-Disopyramide
• α-[2-(Diisopropylamino)ethyl]-α-phenyl-2-pyridineacetamide

Disopyramide

CAS: 3737-09-5

Formula: C₂₁H₂₉N₃O

Purity: >98.0%(HPLC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 339.48

Ref: 3B-D2793

DISOPYRAMIDE CRS

CAS: 3737-09-5

DISOPYRAMIDE CRS

Formula: C₂₁H₂₉N₃O

Color and Shape: Added

Molecular weight: 339.4745

Ref: 41-D2920000

Disopyramide

CAS: 3737-09-5

Disopyramide, or Triombrin, a class I anti-arrhythmic with membrane-stabilizing effects, has heart depressant, anticholinergic, and anesthetic properties.

Formula: C₂₁H₂₉N₃O

Purity: 99.62%

Color and Shape: White Solid

Molecular weight: 339.4745

Ref: TM-T1320

Disopyramide

CAS: 3737-09-5

Disopyramide

Formula: C₂₁H₂₉N₃O

Purity: >98.0%

Molecular weight: 339.47

Ref: 54-OR1027913

Disopyramide

CAS: 3737-09-5

Disopyramide

Formula: C₂₁H₂₉N₃O

Purity: 99.5%

Molecular weight: 339.47

Ref: 54-BUP11369

Disopyramide 1.0 mg/ml in Methanol

CAS: 3737-09-5

Formula: C₂₁H₂₉N₃O

Color and Shape: Colourless

Molecular weight: 339.47

Ref: 61-AMP0108.00-01

Disopyramide

Controlled Product

CAS: 3737-09-5

Formula: C₂₁H₂₉N₃O

Color and Shape: Neat

Molecular weight: 339.47

Ref: 86-MM0108.00

4-Diisopropylamino-2-phenyl-2-(2-pyridyl)butyramide

CAS: 3737-09-5

Formula: C₂₁H₂₉N₃O

Purity: 99%

Color and Shape: Solid

Molecular weight: 339.4745

Ref: IN-DA003VFS

Disopyramide

Controlled Product

CAS: 3737-09-5

Applications Antiarrhythmic (class IA). Sodium channel blocker.
References Adelstein, et al.: J. Med. Chem., 16, 309 (1973), Czeisler, J.L., et al.: J. Pharm. Sci., 74, 750 (1985), Taylor, E.H., et al.: Ann. Clin. Lab. Sci., 16, 289 (1986),

Formula: C₂₁H₂₉N₃O

Color and Shape: Neat

Molecular weight: 339.47

Ref: TR-D493450

Disopyramide

CAS: 3737-09-5

Formula: C₂₁H₂₉N₃O

Purity: ≥ 98.0%

Color and Shape: White solid or powder

Molecular weight: 339.47

Ref: 7W-GE2883

Disopyramide

CAS: 3737-09-5

Formula: C₂₁H₂₉N₃O

Molecular weight: 339.48

Ref: 4Z-D-292001

Disopyramide

CAS: 3737-09-5

Formula: C₂₁H₂₉N₃O

Molecular weight: 339.48

Ref: ST-EA-CP-D169000

Disopyramide

Controlled Product

CAS: 3737-09-5

a-[2-(Diisopropylamino)ethyl]-a-phenyl-2-pyridineacetamide is a hydrogen bond donor. It has been shown to have cytotoxicity in vitro, with parameters that can be used for accurate prediction of descriptors. These descriptors are informative and insightful, which can be used for regression analyses and linear regression methods. The pharmacokinetic properties of a-[2-(Diisopropylamino)ethyl]-a-phenyl-2-pyridineacetamide have been studied in humans and have shown linearity between dose and plasma concentration.

Formula: C₂₁H₂₉N₃O

Color and Shape: White Powder

Molecular weight: 339.47 g/mol

Ref: 3D-FD22542

Disopyramide

CAS: 3737-09-5

Disopyramide

Formula: C₂₁H₂₉N₃O

Purity: 99%

Molecular weight: 339.47

Ref: IN-DG105606

Disopyramide

CAS: 3737-09-5

Formula: C₂₁H₂₉N₃O

Purity: >98.0%(HPLC)(T)

Color and Shape: Solid

Molecular weight: 339.483

Ref: 10-F494167

Disopyramide

CAS: 3737-09-5

Color and Shape: Neat

Ref: 61-FOR0108.00