CAS 37762-06-4

Zaprinast

Description:

Zaprinast is a chemical compound known for its role as a selective inhibitor of phosphodiesterase type 5 (PDE5), which is an enzyme that breaks down cyclic guanosine monophosphate (cGMP). By inhibiting this enzyme, Zaprinast increases the levels of cGMP, leading to vasodilation and enhanced blood flow, particularly in the pulmonary and systemic circulation. This property makes it of interest in the treatment of conditions such as pulmonary hypertension. Zaprinast is characterized by its molecular structure, which includes a pyrimidine ring and a nitro group, contributing to its biological activity. The compound is typically administered in research settings to study its effects on vascular smooth muscle relaxation and other physiological processes. Additionally, Zaprinast has been investigated for its potential neuroprotective effects and its role in various signaling pathways. As with many pharmacological agents, the safety profile and potential side effects are important considerations in its use.

Formula: C₁₃H₁₃N₅O₂

InChI: InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)

InChI key: InChIKey=REZGGXNDEMKIQB-UHFFFAOYSA-N

SMILES: O(CCC)C1=C(C=CC=C1)C=2NC3=C(C(=O)N2)NN=N3

Synonyms:

• 1,4-Dihydro-5-(2-propoxyphenyl)-1,2,3-triazolo(4,5-d)pyrimidin-7-one
• 2-(2-Propoxyphenyl)-8-aza-6-purinone
• 2-(o-Propoxyphenyl)-8-azapurin-6-one
• 2-o-Propoxyphenyl-8-azapurin-6-on
• 2-o-Propoxyphenyl-8-azapurine-6-one
• 3,6-Dihydro-5-(2-propoxyphenyl)-7H-(1,2,3)truaziki(4,5-d)pyrimidin-7-on
• 3,6-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one
• 3,6-Dihydro-5-(o-propoxyphenyl)-7H-v-triazolo(4,5-d)pyrimidin-7-one
• 5-(2-Propoxyphenyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidin-7(4H)-one
• 5-(2-propoxyphenyl)-2,3-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
• 6,7-Dihydro-5-(2-propoxyphenyl)-1H-triazolo(4,5-d)pyrimidin-7-on
• 6,7-Dihydro-5-(2-propoxyphenyl)-1H-triazolo(4,5-d)pyrimidin-7-on [IUPAC]
• 7H-1,2,3-Triazolo(4,5-d)pyrimidin-7-one, 1,4-dihydro-5-(2-propoxyphenyl)-
• 7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one, 3,6-dihydro-5-(2-propoxyphenyl)-
• 8-Aza-2-(2-propoxyphenyl)-6-purinone
• M and B 22948
• M&B 22,948
• Unii-Gxt25D5Ds0
• Zaprinast [INN:BAN]
• Zaprinastum
• Zaprinastum [INN-Latin]

Zaprinast, 98+%

CAS: 37762-06-4

Zaprinast, 98+%

Formula: C₁₃H₁₃N₅O₂

Purity: 98+%

Molecular weight: 271.28

Ref: 02-J63326

Zaprinast

CAS: 37762-06-4

Formula: C₁₃H₁₃N₅O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 271.2746

Ref: IN-DA003VDB

Zaprinast

CAS: 37762-06-4

Zaprinast

Purity: ≥98%

Molecular weight: 271.27g/mol

Ref: 54-BUP11477

Zaprinast

CAS: 37762-06-4

Zaprinast

Purity: 98%

Molecular weight: 271.27g/mol

Ref: 54-OR1023293

Zaprinast

CAS: 37762-06-4

Formula: C₁₃H₁₃N₅O₂

Molecular weight: 271.28

Ref: 7W-GP2697

Zaprinast

CAS: 37762-06-4

Zaprinast is a cGMP-selective phosphodiesterase (PDE) inhibitor and a GPR35 agonist.

Formula: C₁₃H₁₃N₅O₂

Purity: 99.73% - 99.77%

Color and Shape: White To Off White Powder

Molecular weight: 271.27

Ref: TM-T2129

Zaprinast

CAS: 37762-06-4

M02689 - Zaprinast

Formula: C₁₃H₁₃N₅O₂

Purity: >99%

Color and Shape: Solid

Molecular weight: 271.28

Ref: 10-M02689

Zaprinast

Controlled Product

CAS: 37762-06-4

Applications A selective inhibitor of cyclic-GMP phosphodiesterase (PDE V, calmodulin insensitive). Since cGMP mediates the vasorelaxant action of nitric oxide, as well as the natriuretic and diuretic effect of atrial natriuretic factor (ANF) through the activation of PKG (cGMP dependent protein kinase), such inhibitors may display vasodilating, relaxant, and diuretic effects. These compounds may prove useful in treating hypertension and congestive heart failure.
References Burns, F., et al.: Biochem. J., 238, 487 (1992), Lugnier, C., et al.: Am. J. Physiol., 262, H654 (1992),

Formula: C₁₃H₁₃N₅O₂

Color and Shape: Neat

Molecular weight: 271.27

Ref: TR-Z150000

Zaprinast

CAS: 37762-06-4

Phosphodiesterase (PDE5, 6, 9 and 11) inhibitor

Formula: C₁₃H₁₃N₅O₂

Purity: Min. 95%

Color and Shape: Pink To Light (Or Pale) Tan Solid

Molecular weight: 271.27 g/mol

Ref: 3D-FZ28754