CAS 3778-73-2

Ifosfamide

Description:

Ifosfamide is a synthetic alkylating agent primarily used in chemotherapy for treating various cancers, including testicular cancer, sarcomas, and lymphomas. It is a prodrug, meaning it requires metabolic activation in the liver to exert its therapeutic effects. Ifosfamide is structurally related to cyclophosphamide and functions by forming DNA cross-links, which inhibit DNA replication and transcription, ultimately leading to cell death. The compound is typically administered intravenously and is known for its potential side effects, which can include myelosuppression, neurotoxicity, and bladder toxicity, necessitating the use of protective agents like mesna to mitigate these risks. Ifosfamide is characterized by its molecular formula, which includes carbon, hydrogen, nitrogen, and oxygen atoms, and it has a relatively high solubility in water. Its pharmacokinetics involve rapid distribution and metabolism, with a half-life that can vary based on individual patient factors. Overall, Ifosfamide remains an important agent in oncological therapy, despite its associated toxicities.

Formula: C₇H₁₅Cl₂N₂O₂P

InChI: InChI=1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)

InChI key: InChIKey=HOMGKSMUEGBAAB-UHFFFAOYSA-N

SMILES: C(CCl)N1P(NCCCl)(=O)OCCC1

Synonyms:

• (2-Chloro-ethyl)-[3-(2-chloro-ethyl)-2-oxo-2λ*5*-[1,3,2]oxazaphosphinan-2-yl]-amine
• 1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide
• 2,3-N,N(sup 1)-Bis(2-chloroethyl)diamido-1,3,2-oxazaphosphoridinoxy-
• 2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide
• 2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide
• 3-(2-Chloroethyl)-2-(2-chloroethylamino)tetrahydro-2H-1,3,2-oxaazaphosphorin 2-oxide
• 3-(2-Chloroethyl)-2-(2-chloroethylamino)tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide
• 3-(2-Chloroethyl)-2-(2-chloroethylamino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
• 3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorineoxide
• 3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
• A 4942
• Asta Z 4942
• Cyfos
• Holoxan
• Holoxan 1000
• Ifex
• Ifomide
• Ifosfamid
• Ifosfamida
• Ifosfomide
• Ifosphamide
• Iphosphamid
• Iphosphamid(e)
• Iphosphamide
• Isoendoxan
• Isofosfamide
• Isophosphamide
• Mitoxana
• Mjf 9325
• N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
• N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide
• N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid diamide
• Naxamide
• Nsc 109724
• Z 4942
• Z4942

Ifosfamide

CAS: 3778-73-2

Formula: C₇H₁₅Cl₂N₂O₂P

Purity: >95.0%(GC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 261.08

Ref: 3B-I0713

Ifosfamide

CAS: 3778-73-2

Ifosfamide

Formula: C₇H₁₅Cl₂N₂O₂P

Purity: 100.0%

Color and Shape: White To Off-White

Molecular weight: 260.02482

Ref: 47-759

IFOSFAMIDE CRS

CAS: 3778-73-2

IFOSFAMIDE CRS

Formula: C₇H₁₅Cl₂N₂O₂P

Color and Shape: Powder

Molecular weight: 261.086

Ref: 41-I0060000

Ifosfamide

CAS: 3778-73-2

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₇H₁₅Cl₂N₂O₂P

Color and Shape: White Crystalline Powder

Molecular weight: 260.02482

Ref: 45-1336205

3-(2-Chloroethyl)-2-(2-chloroethylamino)tetrahydro-2H-1,3,2-oxaazaphosphorin 2-oxide

CAS: 3778-73-2

Formula: C₇H₁₅Cl₂N₂O₂P

Purity: 98%

Color and Shape: Liquid

Molecular weight: 261.0860

Ref: IN-DA0037J6

Ifosfamide

CAS: 3778-73-2

Ifosfamide (NSC-109724), a prodrug, is a cyclophosphamide analog with antineoplastic action by DNA alkylation and crosslinking.

Formula: C₇H₁₅Cl₂N₂O₂P

Purity: 99.86% - ≥95%

Color and Shape: Solid

Molecular weight: 261.09

Ref: TM-T1055

Ifosfamide

CAS: 3778-73-2

Ifosfamide

Purity: ≥95%

Molecular weight: 261.09g/mol

Ref: 54-BUP16947

Ifosfamide

CAS: 3778-73-2

Formula: C₇H₁₅Cl₂N₂O₂P

Molecular weight: 261.08

Ref: 4Z-I-067001

Ifosfamide

CAS: 3778-73-2

Ifosfamide

Purity: 98%

Molecular weight: 261.09g/mol

Ref: 54-OR1030329

Isophosphamide

CAS: 3778-73-2

Formula: C₇H₁₅Cl₂N₂O₂P

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 261.09

Ref: 7W-GP1861

Ifosfamide

Controlled Product

CAS: 3778-73-2

Formula: C₇H₁₅Cl₂N₂O₂P

Color and Shape: Neat

Molecular weight: 261.09

Ref: 04-C14279000

Ifosfamide - Bio-X ™

CAS: 3778-73-2

Ifosfamide is an alkylating agent and immunosuppressive drug used in chemotherapy for the treatment of various cancers such as ovarian, testicular, cervical and bladder. This drug interferes with the normal process of DNA replication causing damage to the DNA in cancer cells hence preventing them from growing and dividing.

Formula: C₇H₁₅Cl₂N₂O₂P

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 261.09 g/mol

Ref: 3D-BI166243

Ifosfamide

CAS: 3778-73-2

Alkylating agent; anti-cancer agent

Formula: C₇H₁₅Cl₂N₂O₂P

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 261.09 g/mol

Ref: 3D-FB24538

Ifosfamide

Controlled Product

CAS: 3778-73-2

Applications A cytostatic agent, related structurally to cyclophosphamide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Creaven, P. J., et al.: Cancer Treat. Rep., 60, 445(1976), Schoenike, S. E., Clin. Pharm., 9, 179(1990), Skinner, R., et al.: J. Clin. Oncol., 11, 173 (1993).

Formula: C₇H₁₅Cl₂N₂O₂P

Color and Shape: Neat

Molecular weight: 261.09

Ref: TR-I265000

Ifosfamide

CAS: 3778-73-2

Color and Shape: Neat

Ref: 61-FOR0292.00