CAS 3778-73-2
:Ifosfamide
Description:
Ifosfamide is a synthetic alkylating agent primarily used in chemotherapy for treating various cancers, including testicular cancer, sarcomas, and lymphomas. It is a prodrug, meaning it requires metabolic activation in the liver to exert its therapeutic effects. Ifosfamide is structurally related to cyclophosphamide and functions by forming DNA cross-links, which inhibit DNA replication and transcription, ultimately leading to cell death. The compound is typically administered intravenously and is known for its potential side effects, which can include myelosuppression, neurotoxicity, and bladder toxicity, necessitating the use of protective agents like mesna to mitigate these risks. Ifosfamide is characterized by its molecular formula, which includes carbon, hydrogen, nitrogen, and oxygen atoms, and it has a relatively high solubility in water. Its pharmacokinetics involve rapid distribution and metabolism, with a half-life that can vary based on individual patient factors. Overall, Ifosfamide remains an important agent in oncological therapy, despite its associated toxicities.
Formula:C7H15Cl2N2O2P
InChI:InChI=1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)
InChI key:InChIKey=HOMGKSMUEGBAAB-UHFFFAOYSA-N
SMILES:C(CCl)N1P(NCCCl)(=O)OCCC1
Synonyms:- (2-Chloro-ethyl)-[3-(2-chloro-ethyl)-2-oxo-2λ*5*-[1,3,2]oxazaphosphinan-2-yl]-amine
- 1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide
- 2,3-N,N(sup 1)-Bis(2-chloroethyl)diamido-1,3,2-oxazaphosphoridinoxy-
- 2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide
- 2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide
- 3-(2-Chloroethyl)-2-(2-chloroethylamino)tetrahydro-2H-1,3,2-oxaazaphosphorin 2-oxide
- 3-(2-Chloroethyl)-2-(2-chloroethylamino)tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide
- 3-(2-Chloroethyl)-2-(2-chloroethylamino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
- 3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorineoxide
- 3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
- A 4942
- Asta Z 4942
- Cyfos
- Holoxan
- Holoxan 1000
- Ifex
- Ifomide
- Ifosfamid
- Ifosfamida
- Ifosfomide
- Ifosphamide
- Iphosphamid
- Iphosphamid(e)
- Iphosphamide
- Isoendoxan
- Isofosfamide
- Isophosphamide
- Mitoxana
- Mjf 9325
- N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
- N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide
- N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid diamide
- Naxamide
- Nsc 109724
- Z 4942
- Z4942
- See more synonyms
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Ifosfamide
CAS:Formula:C7H15Cl2N2O2PPurity:>95.0%(GC)(T)Color and Shape:White to Light yellow powder to crystalMolecular weight:261.08Ifosfamide
CAS:IfosfamideFormula:C7H15Cl2N2O2PPurity:100.0%Color and Shape:White To Off-WhiteMolecular weight:260.02482Ifosfamide
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C7H15Cl2N2O2PColor and Shape:White Crystalline PowderMolecular weight:260.02482Ifosfamide
CAS:Ifosfamide (NSC-109724), a prodrug, is a cyclophosphamide analog with antineoplastic action by DNA alkylation and crosslinking.Formula:C7H15Cl2N2O2PPurity:99.62% - ≥95%Color and Shape:SolidMolecular weight:261.086Isophosphamide
CAS:Formula:C7H15Cl2N2O2PPurity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:261.09Ifosfamide (Standard)
CAS:Ifosfamide (Standard) is the standard substance of Ifosfamide, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Ifosfamide (NSC-109724) alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mustard cyclophosphamide with antineoplastic activity. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes.Formula:C7H15Cl2N2O2PColor and Shape:SolidMolecular weight:261.0863-(2-Chloroethyl)-2-(2-chloroethylamino)tetrahydro-2H-1,3,2-oxaazaphosphorin 2-oxide
CAS:Formula:C7H15Cl2N2O2PPurity:98%Color and Shape:LiquidMolecular weight:261.0860Ifosfamide
CAS:Controlled ProductApplications A cytostatic agent, related structurally to cyclophosphamide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Creaven, P. J., et al.: Cancer Treat. Rep., 60, 445(1976), Schoenike, S. E., Clin. Pharm., 9, 179(1990), Skinner, R., et al.: J. Clin. Oncol., 11, 173 (1993).Formula:C7H15Cl2N2O2PColor and Shape:NeatMolecular weight:261.09Ifosfamide
CAS:3-(2-Chloroethyl)-2-((2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxideFormula:C7H15Cl2N2O2PPurity:98%Molecular weight:261.09Ifosfamide - Bio-X ™
CAS:Ifosfamide is an alkylating agent and immunosuppressive drug used in chemotherapy for the treatment of various cancers such as ovarian, testicular, cervical and bladder. This drug interferes with the normal process of DNA replication causing damage to the DNA in cancer cells hence preventing them from growing and dividing.Formula:C7H15Cl2N2O2PPurity:Min. 95%Color and Shape:PowderMolecular weight:261.09 g/molIfosfamide
CAS:Alkylating agent; anti-cancer agentFormula:C7H15Cl2N2O2PPurity:Min. 98 Area-%Color and Shape:White Off-White PowderMolecular weight:261.09 g/mol3-(2-Chloroethyl)-2-(2-chloroethylamino)tetrahydro-2H-1,3,2-oxaazaphosphorin 2-oxide
CAS:Purity:98%Molecular weight:261.0799866
