CAS 37784-17-1

N-Boc-D-proline

Description:

N-Boc-D-proline, with the CAS number 37784-17-1, is a derivative of the amino acid proline, characterized by the presence of a tert-butyloxycarbonyl (Boc) protecting group on the nitrogen atom. This modification enhances its stability and solubility, making it a valuable intermediate in peptide synthesis and organic chemistry. N-Boc-D-proline is typically a white to off-white crystalline solid, and it is soluble in common organic solvents such as dichloromethane and dimethylformamide, but less soluble in water. The Boc group serves as a protective moiety that can be removed under acidic conditions, allowing for the selective deprotection of the amino group when needed. This compound is often utilized in the synthesis of peptides and other bioactive molecules, owing to its ability to facilitate the formation of peptide bonds while maintaining the chirality of the D-proline residue. Its structural features and reactivity make it an important building block in medicinal chemistry and drug development.

Formula: C₁₀H₁₆NO₄

InChI: InChI=1/C10H17NO4/c1-10(2,3)15-9(14)11-6-4-5-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/p-1/t7-/m1/s1

SMILES: CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)[O-]

Synonyms:

• (2R)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylate
• 1-Boc-D-proline
• Boc-D-Pro-OH
• Boc-D-proline

N-(tert-Butoxycarbonyl)-D-proline

CAS: 37784-17-1

Formula: C₁₀H₁₇NO₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 215.25

Ref: 3B-B2977

N-Boc-D-proline, 98+%

CAS: 37784-17-1

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₀H₁₇NO₄

Purity: 98+%

Color and Shape: White, Crystals or powder or crystalline powder

Molecular weight: 215.25

Ref: 02-L08826

Boc-D-Pro-OH

CAS: 37784-17-1

Bachem ID: 4000664.

Formula: C₁₀H₁₇NO₄

Purity: > 99.5%

Color and Shape: White

Molecular weight: 215.25

Ref: 01-4000664

N-Boc-D-proline

CAS: 37784-17-1

Formula: C₁₀H₁₇NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 215.2463

Ref: IN-DA0035CW

N-Boc-D-proline

CAS: 37784-17-1

N-Boc-D-proline

Purity: 98%

Color and Shape: White Powder

Molecular weight: 215.25g/mol

Ref: 54-OR307074

N-Boc-D-proline

CAS: 37784-17-1

Formula: C₁₀H₁₇NO₄

Purity: ≥ 98.0%

Color and Shape: White powder or crystals

Molecular weight: 215.25

Ref: 7W-GM9500

Boc-D-Pro-OH

CAS: 37784-17-1

M03316 - Boc-D-Pro-OH

Formula: C₁₀H₁₇NO₄

Purity: 97%

Color and Shape: Solid, Crystalline Powder or Powder

Molecular weight: 215.249

Ref: 10-M03316

N-Boc-D-proline

CAS: 37784-17-1

Formula: C₁₀H₁₇NO₄

Molecular weight: 215.25

Ref: 4Z-P-166060

tert-Butoxycarbonyl-D-proline

Controlled Product

CAS: 37784-17-1

Applications tert-Butoxycarbonyl-D-proline is Boc protected D-proline (P755990). It is used to prepare trichostatin A and trapoxin B analogs as histone deacetylase inhibitors. It is also used to prepare potent and selective nonpeptide inhibitors of caspases 3 and 7.
References Jung, M., et al.: Bioorg. Med. Chem. Lett., 7, 1655 (1997); Lee, D., et al.: J. Med. Chem,, 44, 2015 (2001)

Formula: C₁₀H₁₇NO₄

Color and Shape: Neat

Molecular weight: 215.25

Ref: TR-B692535

N-Boc-D-proline

CAS: 37784-17-1

N-Boc-D-proline is a lipase inhibitor that is used in the preparation of quinine, aldehyde, and carboxylate. N-Boc-D-proline has been shown to inhibit the activity of the sodium channels, which may be due to its ability to bind to the termini of these channels. The inhibition of sodium channels can lead to a decrease in nerve excitability and seizures. N-Boc-D-proline was synthesized by an organocatalytic method using sodium bicarbonate as the catalyst. It was found that this compound was stereoselective with respect to its activity on different enantiomers of chiral substrates. Preparative methods for N-Boc-D-proline include column chromatography or crystallization with diethyl ether or ethyl acetate. The isolated yield is about 99%.

Formula: C₁₀H₁₇NO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 215.25 g/mol

Ref: 3D-FB11371

Boc-D-Pro-OH

CAS: 37784-17-1

Boc-D-Pro-OH is a model compound for the synthesis of peptides. Boc-D-Pro-OH has been used in many surface-enhanced Raman spectroscopy studies to investigate the stereochemistry of glycosidic bonds. It has also been used in pharmacokinetic studies to investigate the drug's absorption, distribution, metabolism, and excretion (ADME) properties. The solute is soluble in water due to its hydrophilic nature. Boc-D-Pro-OH is an enantiomer of Boc-L-Pro-OH and a functional group that contains a trifluoromethyl group. This chemical can be used in Tools for Peptide Synthesis with other compounds to form peptides with specific amino acid sequences.

Formula: C₁₀H₁₇NO₄

Purity: Min. 95%

Molecular weight: 215.25 g/mol

Ref: 3D-BDP-2610

BOC-D-Proline extrapure, 99%

CAS: 37784-17-1

Formula: C₁₀H₁₇NO₄

Purity: min. 99%

Color and Shape: White, Crystalline compound

Molecular weight: 215.30

Ref: SR-93481