CAS 38129-37-2

Bicyclomycin

Description:

Bicyclomycin is a naturally occurring antibiotic that is primarily known for its ability to inhibit bacterial RNA polymerase, thereby interfering with bacterial transcription. It is derived from the bacterium *Streptomyces griseus* and exhibits a unique bicyclic structure that contributes to its biological activity. The compound is characterized by its specific mechanism of action, which targets the enzyme responsible for synthesizing RNA in bacteria, making it effective against a range of Gram-negative bacteria. Bicyclomycin is notable for its low toxicity to eukaryotic cells, which enhances its potential therapeutic applications. Additionally, it has been studied for its role in understanding bacterial resistance mechanisms and the development of new antibiotics. Its chemical properties include solubility in organic solvents and stability under various conditions, although it may be sensitive to extreme pH levels. Overall, bicyclomycin represents a significant compound in the field of antibiotic research, with ongoing studies aimed at optimizing its efficacy and understanding its full range of biological effects.

Formula: C₁₂H₁₈N₂O₇

InChI: InChI=1S/C12H18N2O7/c1-6-3-4-21-12(7(16)10(2,19)5-15)9(18)13-11(6,20)8(17)14-12/h7,15-16,19-20H,1,3-5H2,2H3,(H,13,18)(H,14,17)/t7-,10-,11+,12-/m0/s1

InChI key: InChIKey=WOUDXEYYJPOSNE-VKZDFBPFSA-N

SMILES: [C@@H]([C@@](CO)(C)O)(O)[C@]12C(=O)N[C@](O)(C(=O)N1)C(=C)CCO2

Synonyms:

• (1S,6R)-6-Hydroxy-5-methylene-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione
• (1S,6R)-6-hydroxy-5-methylene-1-(1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione
• (1S,6R)-6-hydroxy-5-methylidene-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione
• 2-Oxa-7,9-diazabicyclo[4.2.2]decane, bicyclomycin deriv.
• 2-Oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione, 6-hydroxy-5-methylene-1-(1,2,3-trihydroxy-2-methylpropyl)-, [1S-[1α,1(1R*,2R*),6β]]-
• 2-Oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione, 6-hydroxy-5-methylene-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-, (1S,6R)-
• 6-Hydroxy-5-Methylidene-1-(1,2,3-Trihydroxy-2-Methylpropyl)-2-Oxa-7,9-Diazabicyclo[4.2.2]Decane-8,10-Dione
• Antibiotic 5879
• Antibiotic WS 4545
• Bicyclomycin
• [1S-[1α,1(1R*,2R*),6β]]-6-Hydroxy-5-methylene-1-(1,2,3-trihydroxy-2-methylpropyl)-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione

Bicyclomycin

CAS: 38129-37-2

Formula: C₁₂H₁₈N₂O₇

Purity: ≥ 95.0%

Color and Shape: White solid

Molecular weight: 302.28

Ref: 7W-GA5701

Bicyclomycin

CAS: 38129-37-2

Bicyclomycin is a broad spectrum antibiotic active against Gram-negative bacteria and the Gram-positive bacterium, Micrococcus luteusn.

Formula: C₁₂H₁₈N₂O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 302.28

Ref: TM-T26805

Bicyclomycin

CAS: 38129-37-2

Formula: C₁₂H₁₈N₂O₇

Molecular weight: 302.28

Ref: 4Z-B-260001

Bicozamycin

CAS: 38129-37-2

Bicozamycin is an antibiotic and is used for the treatment of bacterial infections. It inhibits bacterial RNA polymerase.

Formula: C₁₂H₁₈N₂O₇

Purity: (Hplc-Ms) Min. 90 Area-%

Color and Shape: Powder

Molecular weight: 302.28 g/mol

Ref: 3D-AB61701