CAS 382-67-2
:Desoximetasone
Description:
Desoximetasone is a synthetic corticosteroid primarily used for its anti-inflammatory and immunosuppressive properties in dermatological applications. It is characterized by its ability to reduce inflammation, itching, and redness associated with various skin conditions, such as eczema and psoriasis. The compound exhibits a high potency relative to other topical corticosteroids, making it effective in treating moderate to severe skin disorders. Desoximetasone is typically formulated in topical preparations, including creams and ointments, allowing for localized treatment with minimal systemic absorption. Its mechanism of action involves the inhibition of inflammatory mediators and modulation of immune responses. The substance is generally well-tolerated, although potential side effects may include skin irritation, atrophy, or systemic effects with prolonged use. As with all corticosteroids, it is important to use desoximetasone under medical supervision to minimize risks and ensure appropriate therapeutic outcomes.
Formula:C22H29FO4
InChI:InChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1
InChI key:InChIKey=VWVSBHGCDBMOOT-IIEHVVJPSA-N
SMILES:F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@@H](C(CO)=O)[C@H](C)C3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]
Synonyms:- (11Beta,16Alpha)-9-Fluoro-11,21-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
- (11β,16α)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
- (16Alpha)-9-Fluoro-11,21-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
- (8Xi,10Xi,13Xi,14Xi,16Alpha,17Xi)-9-Fluoro-11,21-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
- 17-Deoxydexamethasone
- 17-Deoxymethansone
- 17-Deoxymethasone
- 17-Desoximethasone
- 9-Fluoro-11-beta,21-dihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione
- 9-Fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
- 9-Fluoro-16α-methyl-Δ1-corticosterone
- 9-Fluoro-16α-methyl-Δ<sup>1</sup>-corticosterone
- 9α-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
- A 41-304
- A 41304
- Brn 2228097
- Deoxymethasone
- Desossimetasone
- Desossimetasone [DCIT]
- Desoximetason
- Desoximetasona
- Desoximetasona [INN-Spanish]
- Desoximetasone [USAN:INN]
- Desoximetasonum
- Desoximetasonum [INN-Latin]
- Desoximethasone
- Desoxymetasone
- Desoxymethasone
- Esperson
- Flubason
- Hoe 304
- Ibaril
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-, (11beta,16alpha)-
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-, (11β,16α)-
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,21-dihydroxy-16α-methyl-
- R 2113
- Stidex
- Stiedex
- Topicort
- Topicort LP
- Topicorte
- Topisolon
- See more synonyms
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Desoximetasone
CAS:Formula:C22H29FO4Purity:>97.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:376.47Desoximetasone
CAS:Halogenated derivatives of adrenal cortical hormonesFormula:C22H29FO4Color and Shape:White PowderMolecular weight:376.20499Desoximetasone-d3 (Dexamethasone EP Impurity F-d3)
CAS:Formula:C22H26D3FO4Color and Shape:White To Off-White SolidMolecular weight:379.49Desoximetasone (Dexamethasone EP Impurity F)
CAS:Formula:C22H29FO4Color and Shape:White To Off-White SolidMolecular weight:376.47Desoximetasone
CAS:DesoximetasoneFormula:C22H29FO4Purity:≥98%Color and Shape:SolidMolecular weight:376.46Desoximetasone
CAS:Formula:C22H29FO4Purity:≥ 97.0%Color and Shape:White to off-white crystalline powderMolecular weight:376.469-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
CAS:Controlled ProductFormula:C22H29FO4Color and Shape:NeatMolecular weight:376.46Desoxymetasone
CAS:Applications Glucocorticoid anti-inflammatory. It is also found as an impurity in Dexamethasone (D298800).
References Schriks, M., et al.: Environ. Sci. Technol., 44, 4766 (2010), Baeck, M., et al.: Eur. J. Dermatol., 20, 102 (2010), Lee, P., et al.: Bioorg. Med. Chem. Lett., 20, 69 (2010),Formula:C22H29FO4Color and Shape:NeatMolecular weight:376.46Desoxymetasone-D5 (Major)
CAS:Controlled ProductApplications Desoxymetasone-D5 is a labelled analogue of Desoxymetasone (D296970). Desoxymetasone is a fluorinated corticosteroid that is structurally related to Dexamethasone (D298800), and is used as a topical cream to treat eczema.
References Heel, R., et al.: Drugs, 16, 302 (1978); Henry, M., et al.: Curr. Med. Res. Opin., 6, 502 (1980); Sehgal, Int. J. Derm., 15, 770 (1976)Formula:C22D5H24FO4Color and Shape:NeatMolecular weight:381.49Desoximetasone
CAS:Desoximetasone (Topicort) is a topical corticosteroid for treating skin conditions like rashes.Formula:C22H29FO4Purity:99.06% - 99.89%Color and Shape:SolidMolecular weight:376.46Desoximetasone in Acetonitrile
CAS:AcetonitrileFormula:C22H29FO4Color and Shape:SolidMolecular weight:376.5Desoximetasone Carboxylic Acid
CAS:Controlled ProductFormula:C22H27FO5Color and Shape:NeatMolecular weight:390.445Desfluoro Chloro Desoximetasone
CAS:Controlled ProductApplications Desfluoro Chloro Desoximetasone is an impurity of Desoxymetasone (D296970) which is anti-inflammatory.
References Schriks, M., et al.: Environ. Sci. Technol., 44, 4766 (2010), Baeck, M., et al.: Eur. J. Dermatol., 20, 102 (2010), Lee, P., et al.: Bioorg. Med. Chem. Lett., 20, 69 (2010),Formula:C22H29ClO4Color and Shape:NeatMolecular weight:392.916
