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CAS 38363-32-5

:

Penbutolol sulfate

Description:
Penbutolol sulfate is a non-selective beta-adrenergic antagonist, primarily used in the treatment of hypertension and certain types of heart conditions. It is characterized by its ability to block beta-1 and beta-2 adrenergic receptors, which helps to reduce heart rate and lower blood pressure. The compound is typically administered in its sulfate form, enhancing its solubility and bioavailability. Penbutolol sulfate is known for its moderate lipophilicity, which allows it to penetrate biological membranes effectively. It exhibits a relatively long half-life, enabling once-daily dosing in clinical settings. Common side effects may include fatigue, dizziness, and gastrointestinal disturbances, reflecting its systemic effects on the cardiovascular system. As with other beta-blockers, caution is advised in patients with asthma or chronic obstructive pulmonary disease due to potential bronchoconstriction. Overall, Penbutolol sulfate is a valuable therapeutic agent in managing cardiovascular diseases, with a well-established profile in clinical practice.
Formula:C18H29NO2H2O4S
InChI:InChI=1S/C18H29NO2.H2O4S/c1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14;1-5(2,3)4/h6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3;(H2,1,2,3,4)/t15-;/m0./s1
InChI key:InChIKey=KTXVDQNRHZQBOR-RSAXXLAASA-N
SMILES:O(C[C@H](CNC(C)(C)C)O)C1=C(C=CC=C1)C2CCCC2.S(=O)(=O)(O)O
Synonyms:
  • (-)-Terbuclomine
  • (2R)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol sulfate (2:1)
  • (2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol sulfate (2:1)
  • 2-Propanol, 1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-, (2S)-, sulfate (2:1)
  • 2-Propanol, 1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-, (2S)-, sulfate (2:1) (salt)
  • HOE 39-893d
  • Levatol
  • Paginol
  • Penbutolol Sulfate
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