CAS 387867-13-2

4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide

Description:

The chemical substance known as 4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide, with CAS number 387867-13-2, is a synthetic compound that belongs to the class of quinazoline derivatives. It is characterized by its complex molecular structure, which includes a quinazoline core, a piperazine moiety, and various functional groups such as methoxy and propoxy substituents. This compound exhibits potential pharmacological properties, often investigated for its role in modulating biological pathways, particularly in the context of neurological or psychiatric disorders. Its structure suggests possible interactions with specific receptors or enzymes, making it a candidate for drug development. The presence of the piperidine and piperazine rings may contribute to its lipophilicity and ability to cross biological membranes. As with many synthetic compounds, its solubility, stability, and reactivity can vary based on environmental conditions and the presence of other substances. Further studies are typically required to fully elucidate its biological activity and therapeutic potential.

Formula: C₃₁H₄₂N₆O₄

InChI: InChI=1/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)

InChI key: InChIKey=UXXQOJXBIDBUAC-UHFFFAOYSA-N

SMILES: CC(C)Oc1ccc(cc1)NC(=O)N1CCN(CC1)c1c2cc(c(cc2ncn1)OCCCN1CCCCC1)OC

Synonyms:

• (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide
• 1-Piperazinecarboxamide, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-
• 4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide
• 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide
• Ct 53518
• Mln 0518
• Mln 518
• Tandutinib
• Tandutinib(TINIBS)

Tandutinib

CAS: 387867-13-2

Formula: C₃₁H₄₂N₆O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 562.7030

Ref: IN-DA007842

Tandutinib

CAS: 387867-13-2

Tandutinib

Formula: C₃₁H₄₂N₆O₄

Purity: ≥98%

Molecular weight: 562.7

Ref: 54-BUP14092

N-(4-Isopropoxyphenyl)-4-(6-Methoxy-7-(3-(Piperidin-1-Yl)Propoxy)Quinazolin-4-Yl)Piperazine-1-Carboxamide

CAS: 387867-13-2

N-(4-Isopropoxyphenyl)-4-(6-Methoxy-7-(3-(Piperidin-1-Yl)Propoxy)Quinazolin-4-Yl)Piperazine-1-Carboxamide

Formula: C₃₁H₄₂N₆O₄

Purity: 99%

Molecular weight: 562.7

Ref: 54-OR1026219

Tandutinib

CAS: 387867-13-2

Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3

Formula: C₃₁H₄₂N₆O₄

Purity: 99.45% - ≥98%

Color and Shape: Solid

Molecular weight: 562.7

Ref: TM-T1667

Tandutinib

CAS: 387867-13-2

Formula: C₃₁H₄₂N₆O₄

Molecular weight: 562.71

Ref: 7W-GP3628

Tandutinib

Controlled Product

CAS: 387867-13-2

Applications An oral, small-molecule inhibitor of FLT3 for the treatment of AML (acute myelogenous leukemia) and other cancer indications. The drug exhibited limited activity as a single agent in phase I and II clinical trials in patients with AML and myelodysplastic syndrome, but displayed promising antileukemic activity (90% complete remissions) in a phase I/II trial in patients with newly diagnosed AML when administered in combination with cytarabine and daunorubicin.
References Manning, G., et al.: Science, 298, 1912 (2002), Lombardo, L., et al.: J. Med. Chem., 47, 6658 (2004), Knight, Z., et al.: Chem. Biol., 12, 621 (2005), Baselga, J., et al.: Science, 312, 1175 (2006), Garber, K., et al.: Nat. Biotechnol., 24, 127 (2006), Flaherty, K., et al.: Clin. Cancer Res., 13, 747 (2007),

Formula: C₃₁H₄₂N₆O₄

Color and Shape: Neat

Molecular weight: 562.7

Ref: TR-T006550

Tandutinib

CAS: 387867-13-2

Tyrosine kinase inhibitor; antineoplastic activity; pro-apoptotic

Formula: C₃₁H₄₂N₆O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 562.7 g/mol

Ref: 3D-FT28001

Tandutinib

CAS: 387867-13-2

N-(4-Isopropoxyphenyl)-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)piperazine-1-carboxamide

Formula: C₃₁H₄₂N₆O₄

Purity: 99%

Molecular weight: 562.7

Ref: IN-DG152374