CAS 388082-77-7

Lapatinib ditosylate

Description:

Lapatinib ditosylate is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of breast cancer, particularly those that are HER2-positive. It functions by inhibiting the activity of the epidermal growth factor receptor (EGFR) and HER2, which are involved in the proliferation and survival of cancer cells. The compound is characterized by its molecular formula, which reflects its complex structure, including a dichloroaniline moiety and a sulfonate group that enhances its solubility. Lapatinib ditosylate is typically administered orally and is known for its ability to penetrate the blood-brain barrier, making it a potential option for treating brain metastases. Its pharmacokinetics include moderate absorption and a half-life that allows for once-daily dosing. Common side effects may include diarrhea, rash, and nausea. As with any targeted therapy, its use is often accompanied by monitoring for efficacy and adverse reactions, emphasizing the importance of personalized medicine in oncology.

Formula:C₄₃H₄₂ClFN₄O₁₀S₃

InChI:InChI=1/C29H26ClFN4O4S.2C6H6O3S.H2O/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;2*7-10(8,9)6-4-2-1-3-5-6;/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2*1-5H,(H,7,8,9);1H2

InChI key:InChIKey=OZDXXJABMOYNGY-UHFFFAOYSA-N

SMILES:N(C=1C2=C(C=CC(=C2)C=3OC(CNCCS(C)(=O)=O)=CC3)N=CN1)C4=CC(Cl)=C(OCC5=CC(F)=CC=C5)C=C4.S(=O)(=O)(O)C1=CC=C(C)C=C1

Synonyms:

4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, 4-methylbenzenesulfonate (1:2)
4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, bis(4-methylbenzenesulfonate)
Benzenesulfonic Acid
Gw 572016F
Hydrate
Lapatinib Ditoyslate
Lapatinib ditosylate anhydrous
Lapatinib, Tykerb, GW572016
N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate)
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6 -[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine h ydrate
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine benzenesulfonate hydrate (1:2:1)
N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylbenzenesulfonate)
Tykerb
Tykerb N-{3-Chloro-4-[(3-fluorophenyl)-methoxy]-phenyl}-6-{5-{(2-methylsulfonylethy amino)-methyl]-2-furyl}-quinazolin-4-amine-benzenesulfonic acid
Lapatinib ditosylate
GW-572016 ditosylate
Lapatinib (GW-572016) Ditosylate
GW 572016 ditosylate
N-{3-chloro-4-[(3-fluorobenzyl)oxyl]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylBenzenesulfonate)
Lapatinib Ditosylate (Tykerb)
N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(Methylsulfonyl)ethyl]aMino}Methyl)-2-furyl]-4-quinazolinaMine 4-Methylbenzenesulfonate (1:2)
GW-572016F Ditosylate
Tykerb Ditosylat
Lapatinib ditasylate
N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-2-yl)quinazolin-4-amine,di4-methylbenzenesulfonate
Tykerb(lapatinib)
Tykerb Ditosylate
See more synonyms

Found 12 products.

+ Info
Lapatinib Ditosylate
CAS:
- 388082-77-7
Formula:C₂₉H₂₆ClFN₄O₄S·2C₇H₈O₃S
Purity:>98.0%(HPLC)(T)
Color and Shape:White to Light yellow powder to crystal
Molecular weight:925.46
Ref: 3B-L0467
1g
74.00€
VAT not included
+ Info
Lapatinib Ditosylate
CAS:
- 388082-77-7
Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).
Formula:C₄₃H₄₂ClFN₄O₁₀S₃
Purity:99.41%
Color and Shape:White Solid
Molecular weight:925.461
Ref: TM-T6235
+ Info
Lapatinib-d4 Ditosylate
CAS:
- 388082-77-7
Formula:C₂₉H₂₂D₄ClFN₄O₄S·2C₇H₈O₃S
Color and Shape:Light Yellow Solid
Molecular weight:585.08 2 172.20
Ref: 4Z-L-253
5mg
To inquire
100mg
To inquire
10mg
1,906.00€
VAT not included
25mg
3,367.00€
VAT not included
50mg
5,421.00€
VAT not included
+ Info
N-(3-Chloro-4-((3-Fluorobenzyl)Oxy)Phenyl)-6-(5-(((2-(Methylsulfonyl)Ethyl)Amino)Methyl)Furan-2-Yl)Quinazolin-4-Amine Bis(4-Methylbenzenesulfonate)
CAS:
- 388082-77-7
N-(3-Chloro-4-((3-Fluorobenzyl)Oxy)Phenyl)-6-(5-(((2-(Methylsulfonyl)Ethyl)Amino)Methyl)Furan-2-Yl)Quinazolin-4-Amine Bis(4-Methylbenzenesulfonate)
Formula:C₄₃H₄₂ClFN₄O₁₀S₃
Purity:98%
Molecular weight:925.46
Ref: 54-PC109179
50mg
32.00€
VAT not included
100mg
32.00€
VAT not included
250mg
36.00€
VAT not included
1g
55.00€
VAT not included
5g
143.00€
VAT not included
+ Info
Lapatinib Ditosylate
CAS:
- 388082-77-7
Formula:C₂₉H₂₆ClFN₄O₄S·2C₇H₈O₃S
Color and Shape:Yellow Solid
Molecular weight:581.06 2*172.20
Ref: 4Z-L-255
5mg
To inquire
100mg
To inquire
10mg
343.00€
VAT not included
25mg
436.00€
VAT not included
50mg
623.00€
VAT not included
+ Info
Lapatinib Ditosylate
CAS:
- 388082-77-7
Lapatinib Ditosylate
Formula:C₂₉H₂₆ClFN₄O₄S·2C₇H₈O₃S
Purity:99%
Molecular weight:925.46
Ref: 54-BUP15047
25mg
62.00€
VAT not included
50mg
85.00€
VAT not included
100mg
103.00€
VAT not included
500mg
186.00€
VAT not included
+ Info
Lapatinib Ditosylate
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 388082-77-7
Applications Reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.
References Kim, T.E., et al.: Drugs, 6, 886 (2003), Wood, E.R., et al.: Cancer Res., 64, 6652 (2004), Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005),
Formula:C₂₉H₂₆ClFN₄O₄S·2C₇H₈O₃S
Color and Shape:Neat
Molecular weight:925.46
Ref: TR-L175800
5mg
97.00€
VAT not included
25mg
127.00€
VAT not included
100mg
227.00€
VAT not included
+ Info
Lapatinib tosylate anhydrous
CAS:
- 388082-77-7
Inhibitor of EGFR (ErbB1) and HER2 (ErbB2) receptor tyrosine kinases. Used for sensitization of HER2-overexpressing cancer cells to radiation as well as chemotherapy to tamoxifen- and trastuzumab-resistant cell lines. The compound blocks signalling via Akt and mitogen-activated protein kinase (MAPK) pathways leading to reduced cell survival. In trastuzumab resistant cancer cells, it inhibits HER2 phosphorylation, prevents receptor ubiquitination and causes accumulation of inactive HER2 dimers on the cell surface.
Formula:C₂₉H₂₆ClFN₄O₄S•(C₇H₈O₃S)₂
Purity:Min. 95%
Color and Shape:Off-White Powder
Molecular weight:925.46 g/mol
Ref: 3D-FL65053
100mg
233.00€
VAT not included
250mg
393.00€
VAT not included
500mg
550.00€
VAT not included
1g
693.00€
VAT not included
2g
1,110.00€
VAT not included
+ Info
Lapatinib Ditosylate
CAS:
- 388082-77-7
Formula:C₄₃H₄₂ClFN₄O₁₀S₃
Molecular weight:925.5
Ref: BE-RMCL024021
10mg
41.00€
VAT not included
+ Info
N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine bis(4-methylbenzenesulfonate)
CAS:
- 388082-77-7
N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine bis(4-methylbenzenesulfonate)
Formula:C₄₃H₄₂ClFN₄O₁₀S₃
Purity:98%
Molecular weight:925.46
Ref: IN-DG135885
+ Info
Lapatinib Ditosylate
CAS:
- 388082-77-7
Formula:C₂₉H₂₆ClFN₄O₄S(C₇H₈O₃S)
Molecular weight:581.06 : 2(172.2)
Ref: ST-EA-CP-L46019
10mg
To inquire
25mg
To inquire
50mg
To inquire
100mg
To inquire
+ Info
Lapatinib ditosylate
CAS:
- 388082-77-7
Formula:C₄₃H₄₂ClFN₄O₁₀S₃
Purity:98%
Color and Shape:Solid
Molecular weight:925.4608
Ref: IN-DA00C6B6
ne
Discontinued
Request information
Discontinued product