CAS 389574-19-0

Prasugrel hydrochloride

Description:

Prasugrel hydrochloride is an antiplatelet medication primarily used to reduce the risk of cardiovascular events in patients with acute coronary syndrome undergoing percutaneous coronary intervention. It is a thienopyridine derivative that acts as a prodrug, requiring metabolic activation to exert its pharmacological effects. The active metabolite irreversibly binds to the P2Y12 receptor on platelets, inhibiting ADP-mediated platelet activation and aggregation. This characteristic makes prasugrel more potent and faster-acting compared to some other antiplatelet agents. The hydrochloride salt form enhances its solubility and stability. Prasugrel is typically administered orally and is known for its favorable pharmacokinetic profile, including a rapid onset of action and a relatively short half-life. Common side effects may include bleeding complications, which necessitate careful patient selection and monitoring. Due to its mechanism of action, prasugrel is contraindicated in patients with a history of transient ischemic attacks or strokes. Overall, prasugrel hydrochloride is a critical therapeutic option in the management of acute coronary syndromes.

Formula: C₂₀H₂₀FNO₃S·ClH

InChI: InChI=1S/C20H20FNO3S.ClH/c1-12(23)25-18-10-14-11-22(9-8-17(14)26-18)19(20(24)13-6-7-13)15-4-2-3-5-16(15)21;/h2-5,10,13,19H,6-9,11H2,1H3;1H

InChI key: InChIKey=JALHGCPDPSNJNY-UHFFFAOYSA-N

SMILES: C(C(=O)C1CC1)(N2CC3=C(CC2)SC(OC(C)=O)=C3)C4=C(F)C=CC=C4.Cl

Synonyms:

• 2-Acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride
• 2-[2-(Acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone hydrochloride
• 5-[2-Cyclopropyl-1-(2-Fluorophenyl)-2-Oxoethyl]-4,5,6,7-Tetrahydrothieno[3,2-C]Pyridin-2-Yl Acetate Hydrochloride (1:1)
• Effient
• Efient
• Ethanone, 2-[2-(acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)-, hydrochloride
• Ethanone, 2-[2-(acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)-, hydrochloride (1:1)
• Prasu Doc
• Prasugrel hydrochloride

PRASUGREL HYDROCHLORIDE CRS

CAS: 389574-19-0

PRASUGREL HYDROCHLORIDE CRS

Ref: 41-Y0002122

Prasugrel Hydrochloride (5-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride)

CAS: 389574-19-0

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₂₀H₂₀FNO₃S·HCl

Color and Shape: White Off-White Powder

Molecular weight: 409.09147

Ref: 45-1554104

Ethanone, 2-[2-(acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)-, hydrochloride (1:1)

CAS: 389574-19-0

Formula: C₂₀H₂₁ClFNO₃S

Purity: 99%

Color and Shape: Solid

Molecular weight: 409.9020

Ref: IN-DA0038RD

Prasugrel Hydrochloride

CAS: 389574-19-0

Prasugrel Hydrochloride

Purity: ≥98%

Molecular weight: 409.9g/mol

Ref: 54-BUP10601

Prasugrel Hydrochloride

CAS: 389574-19-0

Prasugrel Hydrochloride

Purity: 99%

Molecular weight: 409.9g/mol

Ref: 54-PC109001

Prasugrel Hydrochloride

Controlled Product

CAS: 389574-19-0

Formula: C₂₀H₂₀FNO₃S·ClH

Color and Shape: Neat

Molecular weight: 409.90

Ref: 86-MM3637.00

Prasugrel Hydrochloride

CAS: 389574-19-0

Prasugrel Hydrochloride (LY 640315 Hydrochloride) is pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome.

Formula: C₂₀H₂₀FNO₃S·HCl

Purity: 99.39% - 99.79%

Color and Shape: Solid

Molecular weight: 409.9

Ref: TM-T6952

Prasugrel hydrochloride

CAS: 389574-19-0

Formula: C₂₀H₂₀FNO₃S·HCl

Purity: 98.0 - 102.0 % (dried basis)

Color and Shape: White to off-white powder

Molecular weight: 409.90

Ref: 7W-GP8415

Prasugrel Hydrochloride

Controlled Product

CAS: 389574-19-0

Applications A novel antiplatelet agent; it is a third-generation thienopyridine. Antiplatelet agent Prasugrel showed greater platelet inhibition and decreased incidence of ischemic events than Clopidogrel but may induce increased incidence of bleeding in patient with acute coronary syndrome
References Von Beckerath, N., et al.: Circulation, 112, 2946 (2005), Jernberg, T., et al.: Eur. Heart J., 27, 1166 (2006), Farid, N., et al.: Drug Metab. Dispos., 35, 1096 (2007), Farid, N., et al.: Clin. Pharmacol. Ther., 81, 735 (2007), Jakubowski, J., et al.: J. Cardiovasc. Pharmacol., 49, 167 (2007), Wiviott, S., et al.: N. Engl. J. Med., 357, 2001 (2007),

Formula: C₂₀H₂₀FNO₃S·ClH

Color and Shape: Neat

Molecular weight: 409.90

Ref: TR-P701150

Prasugrel Hydrochloride

CAS: 389574-19-0

Formula: C₂₀H₂₀FNO₃SHCl

Molecular weight: 373.4 : 36.4

Ref: ST-EA-CP-P27017