CAS 39012-20-9

Picroside II

Description:

Picroside II is a glycoside compound primarily derived from the root of the plant *Picrorhiza kurroa*, which is known for its medicinal properties in traditional medicine. It is characterized by its bitter taste and is often studied for its potential therapeutic effects, including hepatoprotective, anti-inflammatory, and antioxidant activities. The chemical structure of Picroside II consists of a glucose moiety linked to a phenolic aglycone, contributing to its biological activity. This compound is soluble in water and organic solvents, making it versatile for various applications in herbal formulations and pharmacological research. Additionally, Picroside II has garnered interest for its potential role in treating liver disorders and enhancing immune function. Its safety profile and efficacy are subjects of ongoing research, highlighting the importance of understanding its pharmacokinetics and mechanisms of action in the context of herbal medicine. Overall, Picroside II represents a significant compound in the study of natural products and their applications in health and wellness.

Formula: C₂₃H₂₈O₁₃

InChI: InChI=1/C23H28O13/c1-31-12-6-9(2-3-11(12)26)20(30)34-18-10-4-5-32-21(14(10)23(8-25)19(18)36-23)35-22-17(29)16(28)15(27)13(7-24)33-22/h2-6,10,13-19,21-22,24-29H,7-8H2,1H3/t10?,13-,14?,15-,16+,17-,18?,19?,21?,22+,23?/m1/s1

InChI key: InChIKey=AKNILCMFRRDTEY-UHFFFAOYSA-N

SMILES: C(O)C12C(O1)C(OC(=O)C3=CC(OC)=C(O)C=C3)C4C2C(OC5OC(CO)C(O)C(O)C5O)OC=C4

Synonyms:

• (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl β-<span class="text-smallcaps">D</span>-glucopyranoside
• 2-(Hexopyranosyloxy)-1A-(Hydroxymethyl)-1A,1B,2,5A,6,6A-Hexahydrooxireno[4,5]Cyclopenta[1,2-C]Pyran-6-Yl 4-Hydroxy-3-Methoxybenzoate
• 2-(beta-D-glucopyranosyloxy)-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-6-yl 4-hydroxy-3-methoxybenzoate
• Amphicoside II
• Ampicoside
• Kutkin II
• Oxireno[4,5]cyclopenta[1,2-c]pyran, β-<span class="text-smallcaps">D</span>-glucopyranoside deriv.
• Picroside II
• Vanilloyl catalpol
• beta-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-((4-hydroxy-3-methoxybenzoyl)oxy)-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl, (1aS-(1aalpha,1bbeta,2beta,5abeta,6beta,6aalpha))-
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl, [1aS-(1aα,1bβ,2β,5aβ,6β,6aα)]-
• β-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl, [1aS-(1aα,1bβ,2β,5aβ,6β,6aα)]-
• Oxireno[4,5]cyclopenta[1,2-c]pyran, β-D-glucopyranoside deriv.
• (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl β-D-glucopyranoside
• β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl
• (1aS-(1aalpha,1bbeta,2beta,5abeta,6beta,6aalpha))-1a,1b,2,5a,6,6a-Hexahydro-6-((4-hydroxy-3-methoxybenzoyl)oxy)-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl-beta-D-glucopyranoside
• PICROSID II
• Berberine II
• 6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl,[1aS-(1aα,1bβ,2β,5aβ,6β,6aα)]-
• Picroside a…
• Picroside II, 98%, from Picrorhiza scrophulariiflora Pennell.
• 6'-VANILLOYL CATALPOL
• Picroside II, ≥98% (HPLC)
• Picroside II USP/EP/BP
• AMPHICOSIDE
• PICROSIDE ò
• Picroside-2

Picroside II

CAS: 39012-20-9

Formula: C₂₃H₂₈O₁₃

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 512.46

Ref: 3B-P2594

Picroside 2

CAS: 39012-20-9

Formula: C₂₃H₂₈O₁₃

Purity: ≥ 98.0%

Color and Shape: White, off-white or pale yellow powder

Molecular weight: 512.47

Ref: 7W-GC2669

Picroside II

CAS: 39012-20-9

Picroside II

Formula: C₂₃H₂₈O₁₃

Purity: 95%

Molecular weight: 512.46

Ref: 54-OR1025805

Picroside II

CAS: 39012-20-9

Picroside II

Formula: C₂₃H₂₈O₁₃

Purity: 98.5%

Molecular weight: 512.46

Ref: 54-BUP13396

Picroside II

CAS: 39012-20-9

Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities. It has potent anti-apoptotic activity against renal I/R injury by suppressing the TLR4/NF-κB signaling pathway, it can protect the ischemic kidney against renal fibrosis and improve the neurological function of rats upon cerebral ischemia reperfusion injury. Picroside II enhances nerve growth factor (NGF)-induced neurite outgrowth from PC12D cells by amplifying a down-stream step of MAP kinase in the NGF receptor-mediated intracellular MAP kinase-dependent signaling pathway.

Formula: C₂₃H₂₈O₁₃

Purity: 95%~99%

Molecular weight: 512.464

Ref: BP-BP1100

Picroside II (Standard)

CAS: 39012-20-9

Picroside II (Standard) is a reference standard for research and analysis in studies involving Picroside II. Picroside II (Vanilloyl catalpol) is the main active ingredient in iridoid glycosides. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.

Formula: C₂₃H₂₈O₁₃

Molecular weight: 512.4606

Ref: TM-TMSM-1805

Picroside II

Controlled Product

CAS: 39012-20-9

Applications Picroside II similar to Picroside I (P437635), acts as an oxygen free radical scavenger and thus promotes anti-inflammatory activity and may be used in the treatment of arthritis or ischemic injury.
References Wang, Y. et al.: Res. Neuro. Int. J., 488911, 8 (2014); Singh, G. et al.: Phytother. Res., 7, 402 (1993); Chander R. et al.: Biochem. Pharmacol., 7, 190 (1992);

Formula: C₂₃H₂₈O₁₃

Color and Shape: Neat

Molecular weight: 512.46

Ref: TR-P437640

Picroside II

CAS: 39012-20-9

Picroside II (Vanilloyl catalpol) is the main active ingredient in iridoid glycosides.

Formula: C₂₃H₂₈O₁₃

Purity: 98% - 99.83%

Color and Shape: Solid

Molecular weight: 512.4606

Ref: TM-T2817

Picroside II

CAS: 39012-20-9

(1aS,1bS,2S,5aR,6S,6aS)-1a-(Hydroxymethyl)-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1a,1b,2,5a,6,6a-hexahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-6-yl 4-hydroxy-3-methoxybenzoate

Formula: C₂₃H₂₈O₁₃

Purity: 95%

Molecular weight: 512.46

Ref: IN-DG33504

Picroside II

CAS: 39012-20-9

Natural glycoside

Formula: C₂₃H₂₈O₁₃

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 512.47

Ref: 5G-89759

Picroside-II

CAS: 39012-20-9

Formula: C₂₃H₂₈O₁₃

Molecular weight: 512.5

Ref: BE-RMT12180

Picroside II

CAS: 39012-20-9

Purity: 97%

Molecular weight: 512.153

Ref: 10-F869650

Picroside II

CAS: 39012-20-9

Formula: C₂₃H₂₈O₁₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 512.4606

Ref: IN-DA00BYG2