CAS 39219-28-8

Promestriene

Description:

Promestriene is a synthetic estrogen, primarily used in gynecological applications. It is characterized by its ability to mimic the effects of natural estrogen in the body, making it useful for treating various conditions related to estrogen deficiency, such as atrophic vaginitis and other menopausal symptoms. Promestriene is known for its local action, often administered topically, which minimizes systemic side effects compared to other estrogen therapies. The compound has a relatively low molecular weight and is lipophilic, allowing for effective absorption through mucosal membranes. Its chemical structure features a phenolic ring, which is typical of many steroidal estrogens, contributing to its biological activity. Promestriene is generally well-tolerated, but like all hormonal treatments, it may have potential side effects, including the risk of thromboembolic events. As with any medication, its use should be guided by a healthcare professional, considering individual patient needs and health conditions.

Formula: C₂₂H₃₂O₂

InChI: InChI=1S/C22H32O2/c1-4-13-24-16-6-8-17-15(14-16)5-7-19-18(17)11-12-22(2)20(19)9-10-21(22)23-3/h6,8,14,18-21H,4-5,7,9-13H2,1-3H3/t18-,19-,20+,21+,22+/m1/s1

InChI key: InChIKey=IUWKNLFTJBHTSD-AANPDWTMSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(OCCC)=CC4)(CC1)[H])[H])(CC[C@@H]2OC)[H]

Synonyms:

• (17Beta)-17-Methoxy-3-Propoxyestra-1,3,5(10)-Triene
• (17β)-17-Methoxy-3-propoxyestra-1,3,5(10)-triene
• 17-Methoxy-3-Propoxyestra-1,3,5(10)-Triene
• 3-Propoxy-17Beta-Methoxy-1,3,5(10)-Estratriene
• 3-Propoxy-17β-methoxyestra-1,3,5(10)-triene
• Estra-1,3,5(10)-triene, 17-methoxy-3-propoxy-, (17β)-
• Promestriene

Promestriene

CAS: 39219-28-8

Promestriene (3-propyl ethyl) (INN) is a synthetic estrogen and glucocorticoid used topically in a 1% cream formulation.

Formula: C₂₂H₃₂O₂

Purity: 99.35%

Color and Shape: White Solid

Molecular weight: 328.49

Ref: TM-T1536

Promestriene

CAS: 39219-28-8

Promestriene

Purity: ≥98%

Molecular weight: 328.49g/mol

Ref: 54-BUP10330

Promestriene

CAS: 39219-28-8

Formula: C₂₂H₃₂O₂

Color and Shape: White To Off-White Solid

Molecular weight: 328.50

Ref: 4Z-P-781

Delta-9,11-promestriene

Controlled Product

CAS: 39219-28-8

Applications Delta-9,11-promestriene is a derivative of Promestriene (P756700), which is a synthetic diethyl-ether of Estradiol with no distal hormonal effects, commonly used in patients undergoing surgical correction for stress urinary incontinence (SUI).
References Kelleher, C., et al.: Br. J. Obstet. Gynaecol., 104, 1374 (1997), Deffieux, X., et al.: J. Gynecol. Obstet. Biol. Reprod., 35, 678 (2006)

Formula: C₂₂H₃₀O₂

Color and Shape: Neat

Molecular weight: 326.47

Ref: TR-D231673

Promestriene

Controlled Product

CAS: 39219-28-8

Applications A synthetic diethyl-ether of Estradiol with no distal hormonal effects, in patients undergoing surgical correction for stress urinary incontinence (SUI).
References Kelleher, C., et al.: Br. J. Obstet. Gynaecol., 104, 1374 (1997), Deffieux, X., et al.: J. Gynecol. Obstet. Biol. Reprod., 35, 678 (2006),

Formula: C₂₂H₃₂O₂

Color and Shape: Neat

Molecular weight: 328.49

Ref: TR-P756700

Promestriene

CAS: 39219-28-8

Formula: C₂₂H₃₂O₂

Molecular weight: 328.5

Ref: ST-EA-CP-E61016

Promestriene

Controlled Product

CAS: 39219-28-8

Synthetic estradiol derivative

Formula: C₂₂H₃₂O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 328.49 g/mol

Ref: 3D-FP27181

Promestriene - standard

Controlled Product

CAS: 39219-28-8

Promestriene is a synthetic estrogen derivative, which is sourced from modifications of the natural hormone estradiol. It functions by binding to estrogen receptors, primarily focusing on the mucosal and epithelial tissues. This interaction stimulates cellular proliferation and increases the thickness of the epithelial layers, thereby promoting tissue regeneration and hydration.

Formula: C₂₂H₃₂O₂

Purity: Min. 95%

Molecular weight: 328.49 g/mol

Ref: 3D-ZP181848