CAS 39562-70-4

Nitrendipine

Description:

Nitrendipine is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It belongs to the dihydropyridine class of compounds, which are characterized by their ability to selectively inhibit calcium influx through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation and a subsequent decrease in blood pressure. Nitrendipine is known for its high lipophilicity, which enhances its absorption and distribution in the body. The compound typically exhibits a long half-life, allowing for once-daily dosing in clinical settings. Its chemical structure includes a nitro group, which contributes to its pharmacological properties. Nitrendipine is generally well-tolerated, but like other calcium channel blockers, it may cause side effects such as headache, flushing, or peripheral edema. As with any medication, it is important to consider contraindications and potential interactions with other drugs. Overall, nitrendipine is an effective agent in managing cardiovascular conditions, contributing to improved patient outcomes.

Formula: C₁₈H₂₀N₂O₆

InChI: InChI=1/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,15-16H,5H2,1-4H3/t15?,16-/m1/s1

InChI key: InChIKey=PVHUJELLJLJGLN-UHFFFAOYSA-N

SMILES: C(OCC)(=O)C=1C(C(C(OC)=O)=C(C)NC1C)C2=CC(N(=O)=O)=CC=C2

Synonyms:

• (.+-.)-Bay E 5009
• (.+-.)-Nitrendipine
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-ethyl 5-methyl ester
• Baylotensin
• Bayotensin
• Baypress
• Bylotensin
• Cardif
• Deiten
• Nidrel
• Nitrendipin
• Nitrendipino
• Nitrepin
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl methyl ester
• 3-ethyl 5-methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate
• 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester
• 3-ethyl 5-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate
• ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(meta-nitrophenyl)-3,5-pyridinedicarboxylate
• NITRENDIPINE IMPURITY AETHYL METHYL-2,6-DIMETHYL-4-(3-NITROPHENYL) PYRIDINE-3,5-DICARBOXYLATE
• ylmethylester
• NITRENDIPINE EPN(CRM STANDARD)
• (NITROPHENYLPYRIDINE ANALOGUE) EPN(CRM STANDARD)
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl methyl ester (9CI)
• NITRENDIPINE >95% CA2+ CHANNEL BLOCKER,
• ethylmethyl1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxy
• 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacidethy
• NITRENDIPINE MM(CRM STANDARD)
• baye5009

Nitrendipine

CAS: 39562-70-4

Formula: C₁₈H₂₀N₂O₆

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Yellow to Green powder to crystal

Molecular weight: 360.37

Ref: 3B-N1186

Nitrendipine

CAS: 39562-70-4

L-type calcium channel blocker

Formula: C₁₈H₂₀N₂O₆

Color and Shape: Powder

Molecular weight: 360.37

Ref: 02-J60841

Nitrendipine

CAS: 39562-70-4

Color and Shape: Neat

Ref: 61-FOR0092.00

NITRENDIPINE FOR PEAK IDENTIFICATION CRS

CAS: 39562-70-4

NITRENDIPINE FOR PEAK IDENTIFICATION CRS

Formula: C₁₈H₂₀N₂O₆

Molecular weight: 360.3612

Ref: 41-Y0001456

NITRENDIPINE CRS

CAS: 39562-70-4

NITRENDIPINE CRS

Formula: C₁₈H₂₀N₂O₆

Molecular weight: 360.3612

Ref: 41-N0905000

Nitrendipine

CAS: 39562-70-4

Formula: C₁₈H₂₀N₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 360.3612

Ref: IN-DA003T4X

Nitrendipine

CAS: 39562-70-4

Nitrendipine is a vasodilating calcium channel blocker and antihypertensive that preserves kidney function and promotes sodium excretion.

Formula: C₁₈H₂₀N₂O₆

Purity: 99% - 99.55%

Color and Shape: Solid

Molecular weight: 360.36

Ref: TM-T0119

Nitrendipine

CAS: 39562-70-4

Nitrendipine

Purity: ≥98%

Molecular weight: 360.36g/mol

Ref: 54-BUP15672

Lercanidipine EP Impurity B

CAS: 39562-70-4

Formula: C₁₈H₂₀N₂O₆

Color and Shape: Yellow Solid

Molecular weight: 360.37

Ref: 4Z-L-1714

Nitrendipine

CAS: 39562-70-4

Nitrendipine

Purity: 98%

Molecular weight: 360.36g/mol

Ref: 54-OR1030253

Nitrendipine

CAS: 39562-70-4

Formula: C₁₈H₂₀N₂O₆

Molecular weight: 360.37

Ref: 4Z-N-060002

Nitrendipine

CAS: 39562-70-4

Formula: C₁₈H₂₀N₂O₆

Purity: ≥ 97.0%

Color and Shape: Pale yellow to yellow or green powder

Molecular weight: 360.36

Ref: 7W-GP6940

NITRENDIPINE

CAS: 39562-70-4

Purity: 95+%

Molecular weight: 360.3659973

Ref: 10-F813117

Nitrendipine 100 µg/mL in Acetonitrile

CAS: 39562-70-4

Formula: C₁₈H₂₀N₂O₆

Color and Shape: Single Solution

Molecular weight: 360.36

Ref: 04-A15529500AL-100

Nitrendipine

Controlled Product

CAS: 39562-70-4

Formula: C₁₈H₂₀N₂O₆

Color and Shape: Neat

Molecular weight: 360.36

Ref: 04-C15529500

Nitrendipine

Controlled Product

CAS: 39562-70-4

Formula: C₁₈H₂₀N₂O₆

Color and Shape: Yellow Solid

Molecular weight: 360.36

Ref: 86-MM0092.00

Nitrendipine

Controlled Product

CAS: 39562-70-4

Applications Nitrendipine is a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive.
References Ventura, H.O., et al.: Am. J. Cardiol., 51, 783 (1983); Kann, J. et al.: Brit. J. Clin. Pharmacol., 33, 51 (1992);

Formula: C₁₈H₂₀N₂O₆

Color and Shape: Neat

Molecular weight: 360.36

Ref: TR-N490150

Nitrendipine-d5

Controlled Product

CAS: 39562-70-4

Applications Nitrendipine-d5 is the isotope labelled analogue of Nitrendipine (N490150), a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive.
References Ventura, H.O., et al.: Am. J. Cardiol., 51, 783 (1983),

Formula: C₁₈H₁₅D₅N₂O₆

Color and Shape: Neat

Molecular weight: 365.39

Ref: TR-N490152

(RS)-Methyl ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

CAS: 39562-70-4

Methyl ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate is a propranolol hydrochloride derivative that has vasodilatory effects. It is used as a nitrovasodilator to treat angina pectoris and high blood pressure. Methyl ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate binds to the alpha1 adrenergic receptors in the heart and causes vasodilation by inhibiting the release of norepinephrine from sympathetic nerves. This drug also inhibits the binding of norepinephrine to cardiac beta receptors which decreases the heart rate and contractility of cardiac muscle. Methyl ethyl 1,4-dihydro-2,6

Formula: C₁₈H₂₀N₂O₆

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 360.36 g/mol

Ref: 3D-IM57947

(RS)-Methyl ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate - EP Grade

CAS: 39562-70-4

Propranolol hydrochloride is a non-selective beta-adrenergic blocker that blocks the effects of epinephrine, norepinephrine and dopamine. Propranolol hydrochloride has been shown to inhibit the activity of proximal tubules in the kidney, which may be due to its inhibition of chemical ionization. This drug also has antihypertensive activity and can be used for the treatment of cardiac disorders such as hypertension. Propranolol hydrochloride is a monoclonal antibody that is activated by nitro groups and binds with high affinity to multiple-reaction monitoring (MRM) transitions for protonated molecular ions at m/z 289, 296, 305, 313, 320, 328, 336 and 344. Propranolol hydrochloride also has vasodilatory effects on the papillary muscle which aids in regulating blood pressure by maintaining vascular resistance.

Formula: C₁₈H₂₀N₂O₆

Purity: Min. 95%

Molecular weight: 360.36 g/mol

Ref: 3D-IM175687