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CAS 39562-70-4

:

Nitrendipine

Description:
Nitrendipine is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It belongs to the dihydropyridine class of compounds, which are characterized by their ability to selectively inhibit calcium influx through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation and a subsequent decrease in blood pressure. Nitrendipine is known for its high lipophilicity, which enhances its absorption and distribution in the body. The compound typically exhibits a long half-life, allowing for once-daily dosing in clinical settings. Its chemical structure includes a nitro group, which contributes to its pharmacological properties. Nitrendipine is generally well-tolerated, but like other calcium channel blockers, it may cause side effects such as headache, flushing, or peripheral edema. As with any medication, it is important to consider contraindications and potential interactions with other drugs. Overall, nitrendipine is an effective agent in managing cardiovascular conditions, contributing to improved patient outcomes.
Formula:C18H20N2O6
InChI:InChI=1/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,15-16H,5H2,1-4H3/t15?,16-/m1/s1
InChI key:InChIKey=PVHUJELLJLJGLN-UHFFFAOYSA-N
SMILES:C(OCC)(=O)C=1C(C(C(OC)=O)=C(C)NC1C)C2=CC(N(=O)=O)=CC=C2
Synonyms:
  • (.+-.)-Bay E 5009
  • (.+-.)-Nitrendipine
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-ethyl 5-methyl ester
  • Baylotensin
  • Bayotensin
  • Baypress
  • Bylotensin
  • Cardif
  • Deiten
  • Nidrel
  • See more synonyms
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