CAS 399-52-0

5-Fluoroindole

Description:

5-Fluoroindole is a heterocyclic organic compound characterized by the presence of a fluorine atom at the 5-position of the indole ring system. Its molecular formula is C8H6FN, and it features a bicyclic structure composed of a benzene ring fused to a pyrrole ring. This compound is typically a white to light yellow solid and is known for its aromatic properties, which contribute to its stability and reactivity. 5-Fluoroindole is of interest in medicinal chemistry and material science due to its potential applications in drug development and as a building block for synthesizing more complex molecules. The presence of the fluorine atom can enhance the lipophilicity and metabolic stability of derivatives, making them more effective in biological systems. Additionally, 5-fluoroindole can participate in various chemical reactions, including electrophilic substitutions and coupling reactions, which are valuable in synthetic organic chemistry. Safety data indicates that, like many fluorinated compounds, it should be handled with care due to potential toxicity and environmental concerns.

Formula: C₈H₆FN

InChI: InChI=1S/C8H6FN/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5,10H

InChI key: InChIKey=ODFFPRGJZRXNHZ-UHFFFAOYSA-N

SMILES: c1cc2c(cc[nH]2)cc1F

Synonyms:

• 1H-Indole, 5-fluoro-
• 5-Fluoro Indole
• 5-Fluoro-1H-indole
• Indole, 5-fluoro-
• NSC 88613

5-Fluoroindole

CAS: 399-52-0

Formula: C₈H₆FN

Purity: >98.0%(GC)

Color and Shape: White to Gray to Brown powder to crystal

Molecular weight: 135.14

Ref: 3B-F0369

5-Fluoroindole, 99%

CAS: 399-52-0

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₈H₆FN

Purity: 99%

Color and Shape: Pale cream to cream to pale brown to gray, Crystals or powder or crystalline powder or lumps

Molecular weight: 135.14

Ref: 02-A15346

5-Fluoroindole

CAS: 399-52-0

Formula: C₈H₆FN

Purity: 98%

Color and Shape: Solid

Molecular weight: 135.1383

Ref: IN-DA0037WV

5-Fluoroindole

CAS: 399-52-0

Formula: C₈H₆FN

Purity: (HPLC) ≥ 98.0%

Color and Shape: Off-white to yellow crystalline powder

Molecular weight: 135.14

Ref: 7W-GK0555

5-Fluoro-1H-indole

CAS: 399-52-0

5-Fluoro-1H-indole

Formula: C₈H₆FN

Purity: 97%

Color and Shape: pale yellow solid

Molecular weight: 135.14g/mol

Ref: 54-PC3758

5-Fluoroindole

Controlled Product

CAS: 399-52-0

Applications 5-Fluoroindole is a reactant used in various syntheses. It was used in the synthesis of Spirotetrahydro β-Carbolines (Spiroindolones), which is a new class of potent and orally efficacious compounds for the treatment of malaria. 5-Fluoroindole was also a reactant in direct indole and pyrrole couplings to carbonyl compound in total synthesis of Acremoauxin A and Oxazinin 3.
References Richter, J., et al.: J. Am. Chem. Soc., 129, 12857 (2007); Yeung, B., et al.: J. Med. Chem., 53, 5155 (2010);

Formula: C₈H₆FN

Color and Shape: Neat

Molecular weight: 135.14

Ref: TR-F592140

5-Fluoroindole

CAS: 399-52-0

5-Fluoroindole is a reagent that can be used in organic synthesis. It can be used to synthesize a variety of compounds, including pharmaceuticals and agrochemicals. 5-Fluoroindole is also useful as an intermediate for the synthesis of complex molecules or fine chemicals. 5-Fluoroindole can be used as a building block for the preparation of other chemical compounds. It is a versatile building block with many applications in research and industry.

Formula: C₈H₆FN

Molecular weight: 135.14 g/mol

Ref: 3D-F-4520

5-Fluoroindole

CAS: 399-52-0

Formula: C₈H₆FN

Purity: 96%

Color and Shape: Solid, Flakes or Lumps or Powder

Molecular weight: 135.141

Ref: 10-F006240