CAS 400024-12-6

AMlodipine IMpurity E Maleate

Description:

Amlodipine Impurity E Maleate, with the CAS number 400024-12-6, is a chemical compound associated with the pharmaceutical formulation of amlodipine, a calcium channel blocker used primarily for the treatment of hypertension and angina. This impurity is a byproduct that may arise during the synthesis of amlodipine and is typically characterized by its molecular structure, which includes a maleate moiety. The presence of impurities like Amlodipine Impurity E is significant in pharmaceutical development, as they can affect the efficacy and safety of the final drug product. Analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry are commonly employed to identify and quantify such impurities. Regulatory agencies require stringent control of impurities to ensure that they remain within acceptable limits, thereby safeguarding patient health. Understanding the characteristics of impurities, including their chemical behavior and potential biological effects, is crucial for pharmaceutical quality assurance and compliance with industry standards.

Formula: C₂₅H₃₁ClN₂O₉

InChI: InChI=1S/C21H27ClN2O5.C4H4O4/c1-4-28-20(25)17-13(3)24-16(12-27-11-10-23)19(21(26)29-5-2)18(17)14-8-6-7-9-15(14)22;5-3(6)1-2-4(7)8/h6-9,18,24H,4-5,10-12,23H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key: LPENMFLRVVSIFM-BTJKTKAUSA-N

SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OCC)COCCN)C.C(=C\C(=O)O)\C(=O)O

Synonyms:

• Amlodipine related substance E
• Diethyl (4RS)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate maleate
• (S)-Amlodipine Maleate
• Amlodipine EP Impurity E Maleate：Amlodipine Impurity E Maleate
• AMlodipine IMpurity E Maleate
• Amlodipine Diethyl Ester Maleate
• Amlodipine EP Impurity E Maleate
• Amlodipine impurity E maleic acid

Amlodipine Ethyl Analog (diethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate, maleate)

CAS: 400024-12-6

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₂₁H₂₇ClN₂O₅·C₄H₄O₄

Color and Shape: White Off-White Solid

Molecular weight: 422.16085

Ref: 45-1A00200

Amlodipine EP Impurity E Maleate

CAS: 400024-12-6

Formula: C₂₁H₂₇ClN₂O₅·C₄H₄O₄

Color and Shape: Pale Yellow Solid

Molecular weight: 422.91 116.07

Ref: 4Z-A-089

Amlodipine Diethyl Ester Maleate

Controlled Product

CAS: 400024-12-6

Applications Amlodipine Maleate is an impurity of Amlodipine (A633495), a dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer.
References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986); Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987); Haria, M., et al.: Drugs, 50, 560 (1995)

Formula: C₂₁H₂₇ClN₂O₅·C₄H₄O₄

Color and Shape: Neat

Molecular weight: 538.975

Ref: TR-A633530

Amlodipine EP Impurity E (Maleate salt)

CAS: 400024-12-6

Formula: C₂₁H₂₇ClN₂O₅C₄H₄O₄

Molecular weight: 422.9 : 116.1

Ref: ST-EA-CP-A5069

Amlodipine EP Impurity E maleate

CAS: 400024-12-6

Amlodipine EP Impurity E maleate is a high purity and analytical grade chemical. It is a metabolite of Amlodipine, which is used in the treatment of hypertension. This chemical has been shown to be a natural product that is produced by the human body. It also has been shown to have pharmacological properties, such as anti-inflammatory and vasodilatory effects. The impurity standard for this compound is available from Sigma-Aldrich.br>br>

Formula: C₂₁H₂₇ClN₂O₅•C₄H₄O₄

Purity: Min. 95%

Molecular weight: 538.98 g/mol

Ref: 3D-IA182776