CAS 40034-42-2

Rosoxacin

Description:

Rosoxacin is a synthetic antibacterial agent belonging to the class of quinolone antibiotics. It is primarily characterized by its ability to inhibit bacterial DNA gyrase and topoisomerase IV, enzymes critical for bacterial DNA replication and transcription. This mechanism of action makes Rosoxacin effective against a range of Gram-positive and Gram-negative bacteria. The compound is typically administered orally and is known for its relatively low toxicity profile compared to other antibiotics. Rosoxacin exhibits good bioavailability and is often used in the treatment of various infections, including urinary tract infections and respiratory tract infections. Its chemical structure features a bicyclic core, which is common among quinolones, contributing to its pharmacological properties. Additionally, Rosoxacin has been studied for its potential in treating infections caused by resistant bacterial strains, highlighting its relevance in the context of antibiotic resistance. However, like all antibiotics, its use should be guided by susceptibility patterns to minimize the risk of resistance development.

Formula: C₁₇H₁₄N₂O₃

InChI: InChI=1S/C17H14N2O3/c1-2-19-10-14(17(21)22)16(20)13-4-3-12(9-15(13)19)11-5-7-18-8-6-11/h3-10H,2H2,1H3,(H,21,22)

InChI key: InChIKey=XBPZXDSZHPDXQU-UHFFFAOYSA-N

SMILES: C(C)N1C=2C(C(=O)C(C(O)=O)=C1)=CC=C(C2)C=3C=CN=CC3

Synonyms:

• 1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridinyl)-3-quinolinecarboxylic acid
• 1-Ethyl-4-oxo-7-(pyridin-4-yl)-1,4-dihydroquinoline-3-carboxylic acid
• Acrosoxacin
• Eracin
• Eradacil
• Eradacin
• Nsc 146617
• Rosoxacin
• Rosoxacine
• Rosoxacino
• Roxadyl
• Win 35213
• Winuron
• 3-Quinolinecarboxylic acid, 1-ethyl-1,4-dihydro-4-oxo-7-(4-pyridinyl)-

1-Ethyl-4-oxo-7-(4-pyridyl)-1,4-dihydroquinoline-3-carboxylic Acid

CAS: 40034-42-2

Formula: C₁₇H₁₄N₂O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 294.3047

Ref: IN-DA00C7UN

Rosoxacin

CAS: 40034-42-2

Rosoxacin

Formula: C₁₇H₁₄N₂O₃

Purity: ≥98%

Molecular weight: 294.3

Ref: 54-BUP04974

Rosoxacin

CAS: 40034-42-2

Color and Shape: Neat

Ref: 61-FOR1784.00

Rosoxacin

CAS: 40034-42-2

1-Ethyl-4-oxo-7-(pyridin-4-yl)-1,4-dihydroquinoline-3-carboxylic acid

Formula: C₁₇H₁₄N₂O₃

Purity: 99%

Molecular weight: 294.3

Ref: IN-DG150544

Rosoxacin Hemisulfate

Controlled Product

CAS: 40034-42-2

Applications Rosoxacin has shown to have antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae.
References Koba, M., et. al.: J. Mol. Modeling, 16, 327 (2010)

Formula: C₁₇H₁₄N₂O₃H₂SO₄)

Color and Shape: Neat

Molecular weight: 294.30129808

Ref: TR-R693580

Rosoxacin Potassium Salt (~90%)

Controlled Product

CAS: 40034-42-2

Stability Hygroscopic
Applications Rosoxacin Potassium Salt is an salt analog of Rosoxacin (R693580), an antibacterial agent used against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae.
References Koba, M., et. al.: J. Mol. Modeling, 16, 327 (2010)

Formula: C₁₇H₁₃KN₂O₃

Purity: ~90%

Color and Shape: Neat

Molecular weight: 332.4

Ref: TR-R693585

Rosoxacin-d5

Controlled Product

CAS: 40034-42-2

Formula: C₁₇H₉D₅N₂O₃

Color and Shape: Neat

Molecular weight: 299.34

Ref: TR-R693582

Rosoxacin

CAS: 40034-42-2

Rosoxacin (Acrosoxacin) shows antibacterial activities against a broad spectrum of Gram-negative bacteria including Neisseria gonorrhoeae (MIC90 = 0.03mg/ml).

Formula: C₁₇H₁₄N₂O₃

Purity: 99.1%

Color and Shape: Solid

Molecular weight: 294.3

Ref: TM-T16789

Rosoxacin

CAS: 40034-42-2

Formula: C₁₇H₁₄N₂O₃

Molecular weight: 294.31

Ref: ST-EA-CP-R115500