CAS 40216-83-9

4-Hydroxy-L-proline methyl ester hydrochloride

Description:

4-Hydroxy-L-proline methyl ester hydrochloride is a derivative of proline, an amino acid that plays a crucial role in protein synthesis and collagen formation. This compound features a hydroxyl group at the fourth carbon of the proline ring, which contributes to its unique properties. As a methyl ester, it has a methoxy group attached to the carboxylic acid, enhancing its solubility in organic solvents. The hydrochloride form indicates that it is a salt, which typically improves stability and solubility in aqueous solutions. This compound is often utilized in biochemical research and pharmaceutical applications, particularly in studies related to collagen synthesis and as a potential building block in peptide synthesis. Its molecular structure allows for various interactions, making it a valuable compound in medicinal chemistry. Additionally, it may exhibit biological activities, although specific effects would depend on the context of its use and the biological systems involved. Overall, 4-Hydroxy-L-proline methyl ester hydrochloride is a significant compound in both synthetic and biological chemistry.

Formula: C₆H₁₁NO₃·ClH

InChI: InChI=1S/C6H11NO3.ClH/c1-10-6(9)5-2-4(8)3-7-5;/h4-5,7-8H,2-3H2,1H3;1H/t4-,5+;/m1./s1

InChI key: InChIKey=KLGSHNXEUZOKHH-JBUOLDKXSA-N

SMILES: C(OC)(=O)[C@@H]1C[C@@H](O)CN1.Cl

Synonyms:

• (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid methyl ester hydrochloride
• (2S,4R)-Methyl 4-Hydroxypyrrolidine-2-Carboxylate Hydrochloride
• (4R)-4-Hydroxy-<span class="text-smallcaps">L</span>-proline methyl ester hydrochloride
• 4-Hydroxy-<span class="text-smallcaps">L</span>-proline methyl ester hydrochloride
• 4-Hydroxy-L-Proline Methyl Ester Hcl
• 4-Hydroxyproline ester hydrochloride
• 4-Hydroxyproline methyl ester hydrochloride
• 4-trans-Hydroxy-<span class="text-smallcaps">L</span>-proline methyl ester hydrochloride
• <span class="text-smallcaps">L</span>-Hydroxyproline methyl ester hydrochloride
• <span class="text-smallcaps">L</span>-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-
• <span class="text-smallcaps">L</span>-Proline, 4-hydroxy-, methyl ester, hydrochloride, (4R)-
• <span class="text-smallcaps">L</span>-Proline, 4-hydroxy-, methyl ester, hydrochloride, trans-
• H-D-trans-Hyp-OMe.HCl
• H-Hyp-Ome・Hcl
• H-L-Hyp-Ome Hcl
• Hcl.Trans-D-Hyp-Ome
• Hydroxyproline methyl ester hydrochloride
• Hydroxyproline-Ome Hcl
• L-4-Hydroxyproline Methyl Ester Hydrochloride
• L-4-Hydroxyproline Methyl Ester Hydrochloride Salt
• L-4-Trans-Hydroxyproline Methyl Ester Hydrochloride
• L-4-Trans-Hydroxyproline Methyl Ester Hydrochloride Salt
• L-Trans-4-Hydroxyproline Methyl Ester Hydrochloride Salt
• Methyl (2S,4R)-4-Hydroxypyrrolidine-2-Carboxylate Hydrochloride
• Methyl (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylate hydrochloride
• Methyl <span class="text-smallcaps">L</span>-hydroxyprolinate hydrochloride
• Methyl trans-4-hydroxy-<span class="text-smallcaps">L</span>-prolinate hydrochloride
• Proline, 4-hydroxy-, methyl ester, hydrochloride
• Trans-4-Hydroxy-L-Proline Methyl Ester Hydrochloride
• trans-4-Hydroxy-<span class="text-smallcaps">L</span>-proline methyl ester hydrochloride
• trans-4-Hydroxyproline methyl ester hydrochloride
• L-Proline, 4-hydroxy-, methyl ester, hydrochloride, trans-
• L-Proline, 4-hydroxy-, methyl ester, hydrochloride, (4R)-
• L-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-

trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride

CAS: 40216-83-9

Formula: C₆H₁₁NO₃·HCl

Purity: >98.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 181.62

Ref: 3B-H1533

trans-4-Hydroxy-L-proline methyl ester hydrochloride, 98%

CAS: 40216-83-9

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₆H₁₂ClNO₃

Purity: 98%

Color and Shape: White, Crystals

Molecular weight: 181.62

Ref: 02-H51726

H-Hyp-OMe · HCl

CAS: 40216-83-9

Bachem ID: 4002341.

Formula: C₆H₁₁NO₃·HCl

Purity: > 99%

Color and Shape: White

Molecular weight: 181.62

Ref: 01-4002341

Methyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride

CAS: 40216-83-9

Methyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride

Formula: C₆H₁₁NO₃·ClH

Purity: ≥95%

Color and Shape: White Solid-Crystals

Molecular weight: 181.61737

Ref: 54-OR14759

L-4-Hydroxyproline methyl ester hydrochloride

CAS: 40216-83-9

Formula: C₆H₁₁NO₃HCl

Molecular weight: 181.62

Ref: 7W-GM2861

Methyl trans-4-hydroxy-L-prolinate hydrochloride

CAS: 40216-83-9

Formula: C₆H₁₂ClNO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 181.6174

Ref: IN-DA003UY3

L-4-Hydroxyproline Methyl Ester HCl

CAS: 40216-83-9

Formula: C₆H₁₁NO₃·HCl

Molecular weight: 145.16 36.46

Ref: 4Z-P-166023

H-Hyp-OMe.HCl

CAS: 40216-83-9

H-Hyp-OMe.HCl

Formula: C₆H₁₂ClNO₃

Purity: 95%

Molecular weight: 181.62

Ref: IN-DG2955

H-Hyp-OMe hydrochloride

CAS: 40216-83-9

Formula: C₆H₁₂ClNO₃

Molecular weight: 181.62

Ref: BE-RMCP341021

Methyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride

CAS: 40216-83-9

Formula: C₆H₁₂ClNO₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 181.62

Ref: 10-F066958

trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride

CAS: 40216-83-9

Applications trans-4-Hydroxy-L-proline (H952376) derivative. A natural constituent of animal structural proteins such as collagen and elastin.
References Langmaier, F. et al.: Int. J. Cosm. Sci., 24, 273 (2002); Lawrence, C., et al.: Biochem. J., 313, 185 (1996); Mori, H., et al.: J. Bacteriol.; 179, 5677 (1997); Clifton, I., et al.: Eur. J. Biochem., 268, 6625 (2001)

Formula: C₆H₁₂ClNO₃

Color and Shape: Neat

Molecular weight: 181.62

Ref: TR-H952395

trans-4-Hydroxy-L-proline methyl ester hydrochloride

CAS: 40216-83-9

Trans-4-hydroxy-L-proline methyl ester hydrochloride is a matrix metalloproteinase inhibitor. It inhibits the activity of matrix metalloproteinases, which are enzymes that break down collagen and other proteins in the extracellular matrix. The inhibition of these enzymes leads to a decrease in restenosis, which is the recurrence of artery narrowing after angioplasty or stent placement. Trans-4-hydroxy-L-proline methyl ester hydrochloride has been shown to be effective against chemokine receptors, including CCR5 receptor and chemokines such as TNFα. It also inhibits cytokine production by inhibiting signaling pathways that lead to inflammation and cell proliferation.

Formula: C₆H₁₁NO₃·HCl

Color and Shape: White/Off-White Solid

Molecular weight: 181.62 g/mol

Ref: 3D-FH24381