CAS 405060-95-9

(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide

Description:

The chemical substance known as (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide, with CAS number 405060-95-9, is a synthetic organic compound characterized by its complex structure, which includes a propenamide backbone, a phenyl group, and a quinoline moiety. This compound features multiple functional groups, including amine and thioxomethyl groups, which contribute to its potential biological activity. The presence of trichloro groups suggests that it may exhibit unique reactivity and interactions in biological systems. The quinoline structure is often associated with various pharmacological properties, including antimicrobial and anticancer activities. The compound's specific stereochemistry, indicated by the (2E) configuration, plays a crucial role in its biological interactions and efficacy. Overall, this substance is of interest in medicinal chemistry and may be explored for its therapeutic potential, although detailed studies would be necessary to fully elucidate its properties and applications.

Formula: C₂₁H₁₇Cl₃N₄OS

InChI: InChI=1/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+

InChI key: InChIKey=LCOIAYJMPKXARU-VAWYXSNFNA-N

SMILES: N(C(NC(NC(/C=C/C1=CC=CC=C1)=O)C(Cl)(Cl)Cl)=S)C=2C3=C(C=CC2)C=CC=N3

Synonyms:

• (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
• (2E)-3-Phenyl-N-{2,2,2-trichloro-1-[(quinolin-8-ylcarbamothioyl)amino]ethyl}acrylamide
• 2-propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-, (2E)-
• Salubrinal

(E)-N-(2,2,2-Trichloro-1-(3-(Quinolin-8-yl)Thioureido)Ethyl)Cinnamamide

CAS: 405060-95-9

(E)-N-(2,2,2-Trichloro-1-(3-(Quinolin-8-yl)Thioureido)Ethyl)Cinnamamide

Formula: C₂₁H₁₇Cl₃N₄OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 479.81

Ref: 54-OR1008366

Salubrinal

CAS: 405060-95-9

Salubrinal

Formula: C₂₁H₁₇Cl₃N₄OS

Purity: ≥95%

Color and Shape: Solid

Molecular weight: 479.81

Ref: 54-BUP09986

(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide

CAS: 405060-95-9

Formula: C₂₁H₁₇Cl₃N₄OS

Purity: 99%

Color and Shape: Solid

Molecular weight: 479.8099

Ref: IN-DA00BXDW

Salubrinal

CAS: 405060-95-9

Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).

Formula: C₂₁H₁₇Cl₃N₄OS

Purity: 97.25% - >99.99%

Color and Shape: Solid

Molecular weight: 479.81

Ref: TM-T3045

Salubrinal

CAS: 405060-95-9

(E)-N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnamamide

Formula: C₂₁H₁₇Cl₃N₄OS

Purity: 99%

Molecular weight: 479.81

Ref: IN-DG150791

Salubrinal

CAS: 405060-95-9

M03998 - Salubrinal

Formula: C₂₁H₁₇Cl₃N₄OS

Purity: 99%

Color and Shape: Solid

Molecular weight: 479.8

Ref: 10-M03998

Salubrinal

Controlled Product

CAS: 405060-95-9

Applications Salubrinal is an endoplasmic reticulum stress blocker that modulates sleep homeostasis and activation of sleep- and wake-regulatory neurons
References Methippara, M., et al.: Neurosci., 209, 108 (2012); Huang, X.M., et al.: Neurobiol. Aging. 23, 1007 (2012);

Formula: C₂₁H₁₇Cl₃N₄OS

Color and Shape: Neat

Molecular weight: 479.81

Ref: TR-S100550