CAS 405098-33-1

N-[4-(dimethylamino)benzyl]-7-methoxy-N-[4-(1-methylethyl)phenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide hydrochloride

Description:

N-[4-(dimethylamino)benzyl]-7-methoxy-N-[4-(1-methylethyl)phenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide hydrochloride, with CAS number 405098-33-1, is a synthetic organic compound characterized by its complex molecular structure, which includes a tetrahydronaphthalene core substituted with various functional groups. This compound features a carboxamide functional group, which contributes to its potential biological activity. The presence of dimethylamino and isopropylphenyl substituents suggests that it may exhibit significant lipophilicity, influencing its solubility and permeability in biological systems. The methoxy group can also enhance its pharmacological properties. As a hydrochloride salt, it is likely to be more stable and soluble in aqueous environments, which is advantageous for formulation in pharmaceutical applications. The compound's specific interactions with biological targets would depend on its three-dimensional conformation and the nature of its substituents, making it a candidate for further investigation in medicinal chemistry and drug development.

Formula: C₃₀H₃₇ClN₂O₂

InChI: InChI=1/C30H36N2O2.ClH/c1-21(2)23-11-16-26(17-12-23)32(20-22-9-14-25(15-10-22)31(3)4)30(33)28-8-6-7-24-13-18-27(34-5)19-29(24)28;/h9-19,21,28H,6-8,20H2,1-5H3;1H

InChI key: UKBJWRMNGCDKNL-UHFFFAOYSA-N

SMILES: CC(C)c1ccc(cc1)N(Cc1ccc(cc1)N(C)C)C(=O)C1CCCc2ccc(cc12)OC.Cl

Synonyms:

• 1-naphthalenecarboxamide, N-[[4-(dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-, hydrochloride (1:1)
• N-[4-(Dimethylamino)benzyl]-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxamide hydrochloride (1:1)

W-54011

CAS: 405098-33-1

W-54011

Formula: C₃₀H₃₇ClN₂O₂

Purity: 96.5%

Molecular weight: 493.08

Ref: 54-BUP05250

W-54011

CAS: 405098-33-1

W-54011

Formula: C₃₀H₃₇ClN₂O₂

Purity: 99%

Molecular weight: 493.08

Ref: IN-DG33601

C5a Receptor Antagonist, W-54011

CAS: 405098-33-1

W-54011 is a potentiator of C5a receptor antagonist. It is a protein that binds to the C5a receptor and prevents it from binding to its ligand, C5a. W-54011 has been shown to reduce inflammation in human lung tissues, which may be due to the inhibition of TNF-α and IL-1β production. In animals, W-54011 has been shown to inhibit anaphylatoxin-induced responses, such as airway constriction and vascular permeability. This drug also reduces anaphylactic reactions in humans.

Formula: C₃₀H₃₆N₂O₂·xHCl

Purity: Min. 95%

Molecular weight: 456.62 g/mol

Ref: 3D-FRA09833

W 54011

Controlled Product

CAS: 405098-33-1

Applications W 54011 is a potent orally active non-peptide C5a receptor antagonist.
References Sumichika, H., et al.: J. Biol. Chem., 277, 49403 (2002); Seow, V., et al.: Sci. Rep., 6, 1 (2016);

Formula: C₃₀H₃₆N₂O₂·HCl

Color and Shape: Neat

Molecular weight: 493.1

Ref: TR-W400130

W-54011

CAS: 405098-33-1

W-54011: potent non-peptide C5a receptor blocker; binds 125I-C5a (Ki=2.2nM); stops Ca2+ movement, chemotaxis, ROS in neutrophils (IC50=1.6-3.1nM).

Formula: C₃₀H₃₇ClN₂O₂

Purity: 96.8%

Color and Shape: White Solid

Molecular weight: 493.08

Ref: TM-T17250

C5a Receptor Antagonist, W-54011

CAS: 405098-33-1

Formula: C₃₀H₃₇ClN₂O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 493.0800

Ref: IN-DA00C6K1