CAS 410536-97-9

Sirtinol

Description:

Sirtinol is a small molecule that acts as an inhibitor of sirtuin enzymes, particularly SIRT1, which are involved in various cellular processes including aging, metabolism, and stress response. It is classified as a hydroxamic acid derivative and is known for its potential role in modulating cellular pathways related to longevity and disease. Sirtinol has been studied for its effects on promoting apoptosis in cancer cells and its potential neuroprotective properties. The compound is typically characterized by its ability to interact with the NAD+-dependent deacetylase activity of sirtuins, thereby influencing gene expression and cellular metabolism. In terms of physical properties, Sirtinol is usually presented as a solid at room temperature, with solubility in organic solvents. Its chemical structure includes functional groups that contribute to its biological activity, making it a subject of interest in pharmacological research. However, further studies are needed to fully understand its therapeutic potential and safety profile in clinical applications.

Formula: C₂₆H₂₂N₂O₂

InChI: InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30)

InChI key: InChIKey=UXJFDYIHRJGPFS-UHFFFAOYSA-N

SMILES: C(=NC1=C(C(NC(C)C2=CC=CC=C2)=O)C=CC=C1)C=3C4=C(C=CC3O)C=CC=C4

Synonyms:

• 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
• 2-{[(2-oxonaphthalen-1(2H)-ylidene)methyl]amino}-N-[(1R)-1-phenylethyl]benzamide
• Benzamide, 2-[[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)-
• S 2804
• Sirtinol

Sirtinol

CAS: 410536-97-9

Formula: C₂₆H₂₂N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 394.4651

Ref: IN-DA00BYDM

Sirtinol

CAS: 410536-97-9

Sirtinol

Formula: C₂₆H₂₂N₂O₂

Purity: ≥95%

Molecular weight: 394.47

Ref: 54-BUP13091

Sirtinol

CAS: 410536-97-9

Formula: C₂₆H₂₂N₂O₂

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Yellow powder to crystal

Molecular weight: 394.47

Ref: 3B-S0889

Sirtinol

CAS: 410536-97-9

2-(((2-Hydroxynaphthalen-1-yl)methylene)amino)-N-(1-phenylethyl)benzamide

Formula: C₂₆H₂₂N₂O₂

Purity: 98%

Molecular weight: 394.47

Ref: IN-DG1800

Sirtinol

CAS: 410536-97-9

Formula: C₂₆H₂₂N₂O₂

Purity: ≥ 98%

Color and Shape: Off-white to yellow solid

Molecular weight: 394.5

Ref: 7W-GL5518

Sirtinol

CAS: 410536-97-9

Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).

Formula: C₂₆H₂₂N₂O₂

Purity: 97.12% - 99.96%

Color and Shape: Yellow Solid

Molecular weight: 394.47

Ref: TM-T6671

Sirtinol

CAS: 410536-97-9

M02526 - Sirtinol

Formula: C₂₆H₂₂N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 394.474

Ref: 10-M02526

Sirtinol

Controlled Product

CAS: 410536-97-9

Applications Sirtinol is a known inhibitor of the NAD+-Dependent Protein Desuccinylase and Demalonylase Sirt5 and exhibits anticancer properties.
References Di Fruscia., et al.: MedChemComm., 3, 373 (2012); Rotili, D., et al.: J. Med. Chem., 55, 8193 (2012);

Formula: C₂₆H₂₂N₂O₂

Color and Shape: Neat

Molecular weight: 394.465

Ref: TR-S490930