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CAS 41575-94-4

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Carboplatin

Description:
Carboplatin is a platinum-based chemotherapy drug primarily used in the treatment of various cancers, including ovarian cancer, testicular cancer, and bladder cancer. It is a second-generation platinum compound, structurally related to cisplatin but with a different ligand, which enhances its therapeutic profile and reduces certain side effects. Carboplatin is characterized by its ability to form DNA cross-links, leading to the inhibition of DNA replication and ultimately triggering apoptosis in cancer cells. Its solubility in water allows for intravenous administration, and it is typically given in cycles to maximize efficacy while minimizing toxicity. Common side effects include myelosuppression, nausea, vomiting, and renal toxicity, although these are generally less severe compared to cisplatin. The drug's effectiveness is often influenced by the presence of specific biomarkers in tumors, and it is frequently used in combination with other chemotherapeutic agents to enhance treatment outcomes. Carboplatin's mechanism of action and its relatively favorable side effect profile make it a valuable option in oncological therapies.
Formula:C6H12N2O4Pt
InChI:InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H2;/q;2*-1;+4/p-2/rC6H10N2O4Pt/c7-13(8)11-4(9)6(2-1-3-6)5(10)12-13/h1-3,7-8H2
InChI key:InChIKey=OLESAACUTLOWQZ-UHFFFAOYSA-L
SMILES:O=C1C2(C(=O)[O-][Pt+2]([NH3])([NH3])[O-]1)CCC2
Synonyms:
  • (SP-4-2)-Diammine[1,1-cyclobutanedicarboxylato(2-)-κO,κO′′]platinum
  • 1,1-Cyclobutanedicarboxylic acid, platinum complex
  • Carbomedac
  • Carboplatin
  • Carboplatinum
  • Carbosin
  • Cbdca
  • Cycloplatin
  • Diammin[cyclobutan-1,1-dicarboxylato(2-)-O,O']platin
  • Jm 8
  • See more synonyms
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