CAS 415903-37-6

Grapiprant

Description:

Grapiprant is a non-steroidal anti-inflammatory drug (NSAID) primarily used in veterinary medicine, particularly for the management of pain and inflammation associated with osteoarthritis in dogs. It functions as a selective antagonist of the EP4 receptor, which is a subtype of the prostaglandin E2 receptor. By inhibiting this receptor, Grapiprant effectively reduces pain and inflammation without the gastrointestinal side effects commonly associated with traditional NSAIDs. The chemical structure of Grapiprant includes a pyrimidine ring, contributing to its unique pharmacological profile. It is administered orally and is characterized by its relatively high bioavailability and a favorable safety profile in dogs. Grapiprant's mechanism of action distinguishes it from other NSAIDs, making it a valuable option for managing chronic pain in veterinary patients. As with any medication, it is essential to follow veterinary guidance regarding dosage and administration to ensure the safety and well-being of the animal.

Formula: C₂₆H₂₉N₅O₃S

InChI: InChI=1S/C26H29N5O3S/c1-5-24-29-25-19(4)28-18(3)16-23(25)31(24)21-10-8-20(9-11-21)14-15-27-26(32)30-35(33,34)22-12-6-17(2)7-13-22/h6-13,16H,5,14-15H2,1-4H3,(H2,27,30,32)

InChI key: InChIKey=HZVLFTCYCLXTGV-UHFFFAOYSA-N

SMILES: C(C)C=1N(C=2C(N1)=C(C)N=C(C)C2)C3=CC=C(CCNC(NS(=O)(=O)C4=CC=C(C)C=C4)=O)C=C3

Synonyms:

• AAT 007
• 2-Ethyl-4,6-dimethyl-1-[4-[2-[[[[(4-methylphenyl)sulfonyl]amino]carbonyl]amino]ethyl]phenyl]-1H-imidazo[4,5-c]pyridine
• CJ 023423
• N-((4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenethyl)carbamoyl)-4-methylbenzenesulfonamide
• 2-Ethyl-4,6-dimethyl-1-[4-[2-[[[[(4-methylphenyl)sulfonyl]amino]carbonyl]amino]ethyl]phenyl]-1H-imidazo[4,5-c]pyridine
• N-[[[2-[4-(2-Ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]amino]carbonyl]-4-methylbenzenesulfonamide
• Benzenesulfonamide, N-[[[2-[4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]amino]carbonyl]-4-methyl-

N-((4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenethyl)carbamoyl)-4-methylbenzenesulfonamide

CAS: 415903-37-6

Formula: C₂₆H₂₉N₅O₃S

Purity: %

Color and Shape: Solid

Molecular weight: 491.6052

Ref: IN-DA00C6L9

Grapiprant

CAS: 415903-37-6

Formula: C₂₆H₂₉N₅O₃S

Molecular weight: 491.61

Ref: 4Z-G-227001

Grapiprant

CAS: 415903-37-6

Grapiprant

Purity: ≥98%

Molecular weight: 491.61g/mol

Ref: 54-BUP04595

Grapiprant

CAS: 415903-37-6

Grapiprant

Purity: 98%

Molecular weight: 491.61g/mol

Ref: 54-OR1025656

Grapiprant

CAS: 415903-37-6

Grapiprant (AAT-007) is a selective EP4 receptor antagonist.

Formula: C₂₆H₂₉N₅O₃S

Purity: 99.49% - 99.843%

Color and Shape: Solid

Molecular weight: 491.61

Ref: TM-TQ0292

CJ-023423

CAS: 415903-37-6

Applications CJ-023423 is a potent and selective antagonist of E prostanoid 4 (EP4) receptor.
References Babev, V.R., et al.: Cell Metab. 8, 492 (2008; Li, M. et al.: Int Orthop., 31, 767 (2007)

Formula: C₂₆H₂₉N₅O₃S

Color and Shape: Neat

Molecular weight: 491.61

Ref: TR-C535800

CJ-023423 Hydrochloride Salt, Hydrate

Controlled Product

CAS: 415903-37-6

Formula: C₂₆H₂₉N₅O₃S•x(HCl)y(H₂O)

Color and Shape: Light Beige To Light Yellow

Molecular weight: 491.6136461802

Ref: TR-C535808

CJ-023423 Hydrochloride Salt, Hydrate

CAS: 415903-37-6

CJ-023423 Hydrochloride Salt, Hydrate is a nonsteroidal anti-inflammatory drug (NSAID) that binds to the prostacyclin receptor. CJ-023423 Hydrochloride Salt, Hydrate has been shown to be effective in treating pain in animal models and clinical trials. It also appears to have a low incidence of gastrointestinal side effects. The crystalline form of CJ-023423 Hydrochloride Salt, Hydrate is currently not available for sale.

Formula: C₂₆H₂₉N₅O₃S•(HCl)x•(H₂O)y

Purity: Min. 95%

Molecular weight: 491.61 g/mol

Ref: 3D-QRA90337