CAS 417716-92-8
:Lenvatinib
Description:
Lenvatinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of cancer, including thyroid cancer and renal cell carcinoma. It works by inhibiting multiple receptor tyrosine kinases involved in tumor growth and angiogenesis, such as VEGFR, FGFR, PDGFR, and RET. Lenvatinib is characterized by its chemical formula, which reflects its complex structure, and it typically appears as a white to off-white solid. The substance has a moderate solubility in organic solvents and is generally administered orally in capsule form. Its pharmacokinetics indicate a relatively long half-life, allowing for once-daily dosing. Lenvatinib's efficacy is often evaluated in clinical settings, where it has shown significant improvements in progression-free survival compared to placebo in various studies. However, like many cancer therapies, it may be associated with side effects, including hypertension, fatigue, and gastrointestinal disturbances. Overall, lenvatinib represents a targeted therapeutic approach in oncology, reflecting advancements in personalized medicine.
Formula:C21H19ClN4O4
InChI:InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)
InChI key:InChIKey=WOSKHXYHFSIKNG-UHFFFAOYSA-N
SMILES:O(C=1C2=C(C=C(OC)C(C(N)=O)=C2)N=CC1)C3=CC(Cl)=C(NC(NC4CC4)=O)C=C3
Synonyms:- 4-[3-Chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinolinecarboxamide
- 4-[3-Chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide
- 4-{3-Chloro-4-[(Cyclopropylcarbamoyl)Amino]Phenoxy}-7-Methoxyquinoline-6-Carboxamide
- 6-Quinolinecarboxamide, 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-
- E 7080
- Er 203492-00
- Lenvanix
- Lenvatinib
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Found 14 products.
4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide
CAS:Formula:C21H19ClN4O4Purity:98%Color and Shape:SolidMolecular weight:426.8530Lenvatinib
CAS:Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity.Formula:C21H19ClN4O4Purity:98.46% - 99.96%Color and Shape:White SolidMolecular weight:426.85Lenvatinib (Standard)
CAS:Lenvatinib (Standard) is a reference standard for research and analysis in studies involving Lenvatinib. Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity. Lenvatinib has the strongest inhibitory activity on VEGFR2 and VEGFR3 (IC50=4/5.2 nM). Lenvatinib has strong anti-tumor activity.Formula:C21H19ClN4O4Color and Shape:SolidMolecular weight:426.85Lenvatinib
CAS:4-(3-Chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamideFormula:C21H19ClN4O4Purity:98%Molecular weight:426.85Lenvatinib-d5
CAS:Controlled ProductApplications Lenvatinib-d5 is labelled Lenvatinib (L329400) which is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.
References Matsui, J., et al.: Clin. Cancer Res., 14, 5459 (2008); Gild, M., et al.: Nature Rev. Endocrinol., 7, 617 (2011)Formula:C21H14D5ClN4O4Color and Shape:NeatMolecular weight:431.88Lenvatinib
CAS:Controlled ProductApplications Lenvatinib is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.
References Matsui, J., et al.: Clin. Cancer Res., 14, 5459 (2008); Gild, M., et al.: Nature Rev. Endocrinol., 7, 617 (2011)Formula:C21H19ClN4O4Color and Shape:NeatMolecular weight:426.85Lenvatinib base
CAS:VEGFR2 and VEGFR3 tyrosine kinase inhibitorFormula:C21H19ClN4O4Purity:Min. 95%Color and Shape:White PowderMolecular weight:426.85 g/molLenvatinib base - Bio-X ™
CAS:Lenvatinib is a tyrosine kinase inhibitor that is used to treat cancers such as solid tumours. This drug inhibits the activity of VEGR receptors. It also inhibits other receptors such as fibroblast growth factor.
Formula:C21H19ClN4O4Purity:Min. 95%Color and Shape:PowderMolecular weight:426.85 g/mol
![4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA00379E.jpg&w=3840&q=75)
