CAS 420849-22-5

Thieno[2,3-c]isoquinolin-5(4H)-one

Description:

Thieno[2,3-c]isoquinolin-5(4H)-one is a heterocyclic organic compound characterized by its unique bicyclic structure that incorporates both a thieno and isoquinoline moiety. This compound features a fused ring system, which contributes to its potential biological activity and chemical reactivity. It typically exhibits properties such as moderate solubility in organic solvents and may have limited solubility in water, depending on the specific substituents present. The presence of the thieno ring can impart distinct electronic properties, making it of interest in medicinal chemistry and materials science. Thieno[2,3-c]isoquinolin-5(4H)-one may also exhibit fluorescence, which can be advantageous for applications in organic light-emitting diodes (OLEDs) or as a fluorescent probe in biological systems. Its structural characteristics suggest potential interactions with biological targets, making it a candidate for further investigation in drug discovery and development. As with many heterocycles, the reactivity and stability of this compound can be influenced by the presence of functional groups and the overall molecular environment.

Formula: C₁₁H₇NOS

InChI: InChI=1S/C11H7NOS/c13-10-8-4-2-1-3-7(8)9-5-6-14-11(9)12-10/h1-6H,(H,12,13)

InChI key: InChIKey=LQJVOLSLAFIXSV-UHFFFAOYSA-N

SMILES: O=C1C=2C(C3=C(N1)SC=C3)=CC=CC2

Synonyms:

• Thieno(2,3-C)Isoquinolin-5-One
• Tiq-A
• Thieno[2,3-c]isoquinolin-5(4H)-one

TIQ-A

CAS: 420849-22-5

Formula: C₁₁H₇NOS

Purity: 99%

Color and Shape: Solid

Molecular weight: 201.2444

Ref: IN-DA00C9XH

TIQ-A

CAS: 420849-22-5

Formula: C₁₁H₇NOS

Molecular weight: 201.24

Ref: 7W-GL7485

TIQ-A

CAS: 420849-22-5

TIQ-A

Purity: ≥98%

Molecular weight: 201.24g/mol

Ref: 54-BUP08429

TIQ-A

CAS: 420849-22-5

TIQ-A blocks PARP1 to prevent excessive DNA damage response, implicated in ischemia, asthma, and atherosclerosis.

Formula: C₁₁H₇NOS

Purity: 99.75%

Color and Shape: Solid

Molecular weight: 201.24

Ref: TM-T50098

TIQ-A

Controlled Product

CAS: 420849-22-5

Applications A cell permeable, potent PARP inhibitor with an IC50 of 450nM. Shown to be neuroprotective against oxygen-glucose deprivation injury in vitro in cultured murine cortical cells ( IC50 of 150nM) and in vivi in rat transient focal ischemia model (3 mg/kg ip).
References Chiarugi, A., et al.: J. Pharmacol. Exp. Ther., 305, 43 (2003), pellicciari, R., et al.: Farmaco., 58, 851 (2003)

Formula: C₁₁H₇NOS

Color and Shape: Brown To Dark Blue

Molecular weight: 201.24

Ref: TR-T445100