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CAS 42424-50-0

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polyinosinic-polycytidylic acid sodium

Description:
Polyinosinic-polycytidylic acid sodium, commonly referred to as poly(I:C), is a synthetic double-stranded RNA molecule that serves as a potent immunostimulant. It is composed of alternating inosine and cytidine nucleotides, mimicking viral RNA, which triggers an immune response. Poly(I:C) is known to activate pattern recognition receptors, particularly Toll-like receptor 3 (TLR3), leading to the production of interferons and other cytokines that enhance antiviral defenses. This compound is often used in research and therapeutic applications, particularly in vaccine development and cancer immunotherapy, due to its ability to stimulate innate immunity. Poly(I:C) is typically administered in its sodium salt form, which enhances its solubility and stability in biological systems. Its characteristics include a high molecular weight, a negative charge due to the phosphate backbone, and the ability to form secondary structures that can influence its biological activity. Overall, poly(I:C) is a valuable tool in immunology and therapeutic research, providing insights into immune responses and potential treatment strategies.
Synonyms:
  • Polyinosinic Acid . Polycytidylic Acid, Sodium Salt, Double
  • Polyinosinic-Polycytidylic Acid Sodium Salt
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