CAS 4270-27-3

6-Chlorouracil

Description:

6-Chlorouracil is a halogenated derivative of uracil, classified as a pyrimidine nucleobase. Its chemical formula is C4H3ClN2O2, and it features a chlorine atom substituted at the 6-position of the uracil ring. This compound is primarily known for its role in medicinal chemistry, particularly as an antimetabolite in cancer treatment, where it can inhibit the synthesis of nucleic acids. 6-Chlorouracil exhibits properties such as being a white to off-white crystalline solid, with moderate solubility in water and organic solvents. Its structure allows it to mimic natural nucleobases, which can interfere with DNA and RNA synthesis in rapidly dividing cells. Additionally, it has been studied for its potential antiviral properties. Safety considerations include handling it with care due to its potential toxicity and the need for proper laboratory protocols when working with such compounds. Overall, 6-Chlorouracil is significant in both research and therapeutic contexts, particularly in oncology.

Formula: C₄H₃ClN₂O₂

InChI: InChI=1S/C4H3ClN2O2/c5-2-1-3(8)7-4(9)6-2/h1H,(H2,6,7,8,9)

InChI key: InChIKey=PKUFNWPSFCOSLU-UHFFFAOYSA-N

SMILES: ClC1=CC(=O)NC(=O)N1

Synonyms:

• 2,4(1H,3H)-Pyrimidinedione, 6-chloro-
• 4-(3-bromophenyl)-1H-pyrazole
• 4-Chloro-2,6-dihydroxypyrimidine
• 4-Chlorouracil
• 6-Chloro-2,4(1H,3H)-pyrimidinedione
• 6-Chloro-2,4-dihydroxypyrimidine
• 6-Chloro-2,4-pyrimidinediol
• 6-Chloropyrimidine-2,4-dione
• 6-chloropyrimidine-2,4(1H,3H)-dione
• NSC 210419
• NSC 43265
• Uracil, 6-chloro-
• 6-Chlorouracil

6-Chlorouracil

CAS: 4270-27-3

Formula: C₄H₃ClN₂O₂

Purity: >98.0%(T)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 146.53

Ref: 3B-C2093

4-Chlorouracil

CAS: 4270-27-3

Formula: C₄H₃ClN₂O₂

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 146.53

Ref: 7W-GE4840

6-Chlorouracil

CAS: 4270-27-3

6-Chlorouracil

Formula: C₄H₃ClN₂O₂

Purity: 98%

Color and Shape: White Solid

Molecular weight: 146.53181

Ref: 54-OR5447

6-Chlorouracil

CAS: 4270-27-3

Formula: C₄H₃ClN₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 146.5318

Ref: IN-DA0034CW

6-Chlorouracil

CAS: 4270-27-3

Formula: C₄H₃ClN₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 146.53

Ref: 10-F023418

6-Chloropyrimidine-2,4(1H,3H)-dione

CAS: 4270-27-3

6-Chloropyrimidine-2,4(1H,3H)-dione

Formula: C₄H₃ClN₂O₂

Purity: 98%

Molecular weight: 146.53

Ref: IN-DG9392

6-Chlorouracil

CAS: 4270-27-3

Intermediate in the synthesis of alogliptin

Formula: C₄H₃ClN₂O₂

Color and Shape: White Slightly Yellow Powder

Molecular weight: 146.53 g/mol

Ref: 3D-FC07107

6-Chlorouracil

Controlled Product

CAS: 4270-27-3

Applications 6-Chlorouracil acts as an inhibitor of yeast alcohol dehydrogenase (ADH-H). 6-Chlorouracil is a potential inhibitor of DNA repair glycosylases.
References Gauri, K.K.: Arch. Pharm., 306, 622 (1973); Speina, E. et al.: Acta Biochim. Pol., 52, 167 (2005);

Formula: C₄H₃ClN₂O₂

Color and Shape: Neat

Molecular weight: 146.53

Ref: TR-C423780

6-Chlorouracil

CAS: 4270-27-3

Formula: C₄H₃ClN₂O₂

Molecular weight: 146.53

Ref: ST-EA-CP-F32024