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CAS 42935-17-1

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PGH2

Description:
PGH2, or Prostaglandin H2, is a biologically active lipid compound that plays a crucial role in various physiological processes. It is an intermediate in the biosynthesis of prostaglandins, which are important signaling molecules involved in inflammation, pain, and the regulation of various bodily functions. PGH2 is characterized by its unstable nature, as it readily undergoes further enzymatic conversion to other prostaglandins, such as PGE2 and PGI2, which have distinct biological activities. The compound is typically synthesized from arachidonic acid through the action of cyclooxygenase enzymes. PGH2 is known for its role in mediating inflammatory responses and is involved in the regulation of vascular tone and platelet aggregation. Due to its short half-life and reactivity, PGH2 is not usually found in significant quantities in biological systems but is crucial in the context of prostaglandin synthesis. Its study is important in pharmacology and medicine, particularly in understanding the mechanisms of pain and inflammation and the development of anti-inflammatory drugs.
Formula:C20H32O5
InChI:InChI=1/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
InChI key:InChIKey=YIBNHAJFJUQSRA-YNNPMVKQSA-N
SMILES:C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](CCCCC)O)[C@]2(C[C@@]1(OO2)[H])[H]
Synonyms:
  • (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoic acid
  • (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid
  • (5Z,9α,11α,13E,15S)-9,11-Epidioxy-15-hydroxyprosta-5,13-dien-1-oic acid
  • 15-Hydroxy-9α,11α-peroxidoprosta-5,13-dienoic acid
  • 2,3-Dioxabicyclo[2.2.1]heptane, prosta-5,13-dien-1-oic acid deriv.
  • 7-[6-(3-Hydroxyoct-1-En-1-Yl)-2,3-Dioxabicyclo[2.2.1]Hept-5-Yl]Hept-5-Enoic Acid
  • 9,11-Epoxymethano-pgh2
  • Endoperoxide H<sub>2</sub>
  • PGH<sub>2</sub>
  • Pgh 2
  • See more synonyms
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