CAS 4298-15-1

(±)-Desethylhydroxychloroquine

Description:

(±)-Desethylhydroxychloroquine, with the CAS number 4298-15-1, is a chemical compound related to hydroxychloroquine, a medication primarily used to prevent and treat malaria and autoimmune diseases such as lupus and rheumatoid arthritis. This substance is characterized by its structural modifications, specifically the removal of the ethyl group from hydroxychloroquine, which influences its pharmacological properties. It typically appears as a white to off-white crystalline solid and is soluble in polar solvents. The compound exhibits antimalarial and immunomodulatory activities, although its efficacy and safety profile may differ from its parent compound. Its mechanism of action involves interference with the lysosomal function in immune cells, leading to altered antigen processing and reduced inflammation. As a derivative, (±)-desethylhydroxychloroquine is of interest in research contexts, particularly in studying drug metabolism and the development of new therapeutic agents. However, its clinical applications and potential side effects require further investigation to establish its therapeutic viability.

Formula: C₁₆H₂₂ClN₃O

InChI: InChI=1S/C16H22ClN3O/c1-12(3-2-7-18-9-10-21)20-15-6-8-19-16-11-13(17)4-5-14(15)16/h4-6,8,11-12,18,21H,2-3,7,9-10H2,1H3,(H,19,20)

InChI key: InChIKey=XFICNUNWUREFDP-UHFFFAOYSA-N

SMILES: N(C(CCCNCCO)C)C=1C2=C(N=CC1)C=C(Cl)C=C2

Synonyms:

• 2-((4-((7-Chloro-4-quinolyl)amino)pentyl)amino)ethanol
• 2-({4-[(7-Chloroquinolin-4-Yl)Amino]Pentyl}Amino)Ethanol
• 2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]amino]ethanol
• Cletochina
• Cletochina [DCIT]
• Cletoquina
• Cletoquina [INN-Spanish]
• Cletoquine [INN:BAN]
• Cletoquinum
• Cletoquinum [INN-Latin]
• Desethylhydroxychloroquine
• Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]amino]-
• Ethanol, 2-[[4-[(7-chloro-4-quinolyl)amino]pentyl]amino]-
• Unii-83Cvd213Tu
• Cletoquine
• 2-[4-[(7-chloroquinolin-4-yl)amino]pentylamino]ethanol
• Hydroxychloroquine Sulfate Impurity 3（Hydroxychloroquine Sulfate EP Impurity C）
• Hydroxychloroquine Sulfate EP Impurity C (Desethyl Hydroxy Chloroquine)
• Hydroxychloroquine EP Impurity C (Phosphate)
• Hydroxychloroquine?EP?Impurity?C/Desethyl?Hydroxychloroquine/Cletoquine/2-[[(4RS)-4-[(7-Chloroquinolin-4-yl)amino]pentyl]amino]ethan-1-ol
• DESETHYL HYDROXY CHLOROQUINE
• Desethylhydroxychloroquine Dihydroc
• Desethyl Hydroxy Chloroquine DiHCl

2-[4-[(7-chloro-4-quinolinyl)amino]pentyl] amino ethanol sulfate

CAS: 4298-15-1

2-[4-[(7-chloro-4-quinolinyl)amino]pentyl] amino ethanol sulfate

Formula: C₁₈H₂₈ClN₃O₅S

Color and Shape: Off-White. To. Yellow

Molecular weight: 433.95

Ref: 47-1101

Desethyl hydroxy chloroquine

CAS: 4298-15-1

Formula: C₁₆H₂₂ClN₃O

Purity: %

Color and Shape: Solid

Molecular weight: 307.8184

Ref: IN-DA00BXO2

Hydroxychloroquine Sulfate EP Impurity C (Desethyl Hydroxy Chloroquine)

CAS: 4298-15-1

Formula: C₁₆H₂₂ClN₃O

Color and Shape: White To Off-White Solid

Molecular weight: 307.82

Ref: 4Z-H-064

Cletoquine

CAS: 4298-15-1

Cletoquine

Purity: ≥95%

Molecular weight: 307.82g/mol

Ref: 54-BUP00500

Hydroxychloroquine Sulfate EP Impurity C DiHCl (Desethyl Hydroxy Chloroquine DiHCl)

CAS: 4298-15-1

Formula: C₁₆H₂₂ClN₃O·2HCl

Color and Shape: White To Off-White Solid

Molecular weight: 307.82 2*36.46

Ref: 4Z-H-063

Cletoquine

CAS: 4298-15-1

Cletoquine, Hydroxychloroquine's active metabolite, fights CHIKV, has antimalarial properties, and may treat autoimmune diseases.

Formula: C₁₆H₂₂ClN₃O

Purity: 99.95% - 99.98%

Color and Shape: Solid

Molecular weight: 307.82

Ref: TM-T10835

Cletoquine-d4

Controlled Product

CAS: 4298-15-1

Applications Cletoquine-d4 is the isotope labelled analog of Cletoquine, which is a metabolite of Hydroxychloroquine (H916900), an antimalarial; antirheumatic; lupus erythematosus suppressant.
References Yarden, Y., et al.: Nature, 323, 226 (1986); Seifert, R., et al.: J. Biol. Chem., 264, 8771 (1989); Gahl, W., et al.: Mol. Genet. Metab., 76, 234 (2002); Card, J., et al.: Toxicol. Sci., 75, 169 (2003)

Formula: C₁₆D₄H₁₈ClN₃O

Color and Shape: Neat

Molecular weight: 311.84

Ref: TR-C573507

Cletoquine

Controlled Product

CAS: 4298-15-1

Applications Cletoquine is a metabolite of Hydroxychloroquine (H916900), an antimalarial; antirheumatic; lupus erythematosus suppressant.
References Yarden, Y., et al.: Nature, 323, 226 (1986); Seifert, R., et al.: J. Biol. Chem., 264, 8771 (1989); Gahl, W., et al.: Mol. Genet. Metab., 76, 234 (2002); Card, J., et al.: Toxicol. Sci., 75, 169 (2003)

Formula: C₁₆H₂₂ClN₃O

Color and Shape: Neat

Molecular weight: 307.82

Ref: TR-C573505

Hydroxychloroquine EP Impurity C

CAS: 4298-15-1

Formula: C₁₆H₂₂ClN₃O

Molecular weight: 307.82

Ref: ST-EA-CP-H4003

2-[4-[(7-Chloroquinolin-4-yl)amino]pentylamino]ethanol

CAS: 4298-15-1

2-[4-[(7-Chloroquinolin-4-yl)amino]pentylamino]ethanol is an α1-acid glycoprotein (AAG) inhibitor. It has a matrix effect on analytical methods and can be used to prepare samples for analysis. 2-[4-[(7-Chloroquinolin-4-yl)amino]pentylamino]ethanol inhibits autophagy, which is the process of degradation of cellular components by lysosomes. It has been shown to have disease activity against autoimmune diseases and HIV infection. Animal studies have shown that 2-[4-[(7-Chloroquinolin-4-yl)amino]pentylamino]ethanol can reduce inflammation in rat liver microsomes and has antiarthritic effects in rats with adjuvant arthritis. This drug also has dose group effects on serum creatinine, urea nitrogen, and uric acid levels.

Formula: C₁₆H₂₂ClN₃O

Purity: 85%Nmr

Color and Shape: White To Beige To Light Brown Solid

Molecular weight: 307.82 g/mol

Ref: 3D-FC29937