CAS 43157-23-9

(Deamino-Cys1,Val4,D-Arg8)-Vasopressin

Description:

(Deamino-Cys1,Val4,D-Arg8)-Vasopressin, also known as a synthetic analog of the natural hormone vasopressin, is a peptide that exhibits specific structural modifications to enhance its pharmacological properties. This compound is characterized by the substitution of the amino acids at positions 1, 4, and 8, which alters its receptor binding affinity and biological activity. The deamino modification at the first position removes an amino group, contributing to increased stability and resistance to enzymatic degradation. The valine at position 4 and the D-arginine at position 8 further enhance its potency and selectivity for vasopressin receptors, particularly the V1 and V2 subtypes. This peptide is primarily studied for its potential therapeutic applications in managing conditions such as diabetes insipidus and certain types of bleeding disorders. Its unique structure allows for improved pharmacokinetics, making it a valuable compound in both clinical and research settings. As with many peptides, its activity is closely related to its three-dimensional conformation, which is essential for receptor interaction and subsequent biological effects.

Synonyms:

• 3-Mercaptopropionyl-Tyr-Phe-Val-Asn-Cys-Pro-D-Arg-Gly-NH2 (Disulfide bond)

(Deamino-Cys¹,Val⁴,D-Arg⁸)-Vasopressin

CAS: 43157-23-9

Highly potent, long-lasting antidiuretic agonist essentially devoid of vasopressor activity.

Formula: C₄₆H₆₅N₁₃O₁₁S₂

Purity: 99.4%

Color and Shape: White Powder

Molecular weight: 1040.24

Ref: 01-4031341

[deamino-Cys1, Val4, D-Arg8]-Vasopressin TFA Salt

Controlled Product

CAS: 43157-23-9

Formula: C₄₆H₆₅N₁₃O₁₁S₂•x(C₂HF₃O₂)

Color and Shape: Neat

Molecular weight: 1040.22 + x(114.02)

Ref: TR-C997953

(Deamino-Cys1,Val4,D-Arg8)-Vasopressin

CAS: 43157-23-9

Vasopressin 3-mercaptopropionyl-Tyr-Phe-Val-Asn-Cys-Pro-D-Arg-Gly-NH2 is a peptide hormone that is involved in the regulation of water balance and blood pressure. It is a vasoconstrictor and has been shown to have an inhibitory effect on cellular targets such as soluble guanylate cyclase, which are involved in the synthesis of cGMP. Vasopressin 3-mercaptopropionyl-Tyr-Phe-Val-Asn-Cys Pro D Arg Gly NH2 also binds to the oxytocin receptor, which may be responsible for its vasodilatory effect.

Formula: C₄₆H₆₅N₁₃O₁₁S₂

Purity: Min. 95%

Molecular weight: 1,040.22 g/mol

Ref: 3D-FD108910