CAS 432531-71-0

Formula: C18H15N5O6S2

InChI: InChI=1S/C18H15N5O6S2/c1-29-18-17(19-10-11-20-18)22-31(27,28)14-6-2-12(3-7-14)21-15(24)8-4-13-5-9-16(30-13)23(25)26/h2-11H,1H3,(H,19,22)(H,21,24)/b8-4+

InChI key: FNPPHVLYVGMZMZ-XBXARRHUSA-N

SMILES: COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(S3)[N+](=O)[O-]

(E/Z)-Necrosulfonamide

CAS: 432531-71-0

(E/Z)-Necrosulfonamide

Formula: C₁₈H₁₅N₅O₆S₂

Purity: ≥95%

Molecular weight: 461.47

Ref: 54-BUP09704

(E/Z)-Necrosulfonamide

CAS: 432531-71-0

Formula: C₁₈H₁₅N₅O₆S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 461.4716

Ref: IN-DA00DF2R

(E/Z)-Necrosulfonamide

CAS: 432531-71-0

N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide

Formula: C₁₈H₁₅N₅O₆S₂

Purity: 98%

Molecular weight: 461.47

Ref: IN-DG01145517

(E/Z)-Necrosulfonamide

CAS: 432531-71-0

(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.

Formula: C₁₈H₁₅N₅O₆S₂

Purity: 98% - 98.99%

Color and Shape: Solid

Molecular weight: 461.472

Ref: TM-T7129

N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide

CAS: 432531-71-0

Formula: C₁₈H₁₅N₅O₆S₂

Purity: 98%

Molecular weight: 461.47

Ref: 10-F546456

Necrosulfonamide

Controlled Product

CAS: 432531-71-0

Applications Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.
References Sun, L. et al.: Cell, 148, 213 (2012);

Formula: C₁₈H₁₅N₅O₆S₂

Color and Shape: Neat

Molecular weight: 461.47

Ref: TR-N388600

MLKL Inhibitor, Necrosulfonamide

CAS: 432531-71-0

Necrosulfonamide is a chemical inhibitor of MLKL, a protein that is involved in apoptosis and necroptosis. Necrosulfonamide has been shown to inhibit the kinase activity of MLKL and induce cell death by apoptosis or necroptosis. It has also been shown to inhibit cancer cell growth and suppress tumor development in animal models. Necrosulfonamide binds to MLKL and prevents its interaction with other proteins, inhibiting mitochondrial functions and leading to necrosis or necroptosis. Necrosulfonamide has also shown anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.

Formula: C₁₈H₁₅N₅O₆S₂

Purity: Min. 95%

Molecular weight: 461.47 g/mol

Ref: 3D-HSA53171