CAS 439588-33-7

Formula: C22H14F2N6O

InChI: InChI=1S/C22H14F2N6O/c23-13-5-1-11(2-6-13)19-16(10-27-28-19)17-15(9-25)21(26)31-22-18(17)20(29-30-22)12-3-7-14(24)8-4-12/h1-8,10,17H,26H2,(H,27,28)(H,29,30)

InChI key: GKUJGEJKDIGMCJ-UHFFFAOYSA-N

SMILES: C1=CC(=CC=C1C2=C(C=NN2)C3C(=C(OC4=NNC(=C34)C5=CC=C(C=C5)F)N)C#N)F

Hsp90-IN-34

CAS: 439588-33-7

Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.

Formula: C₂₂H₁₄F₂N₆O

Color and Shape: Solid

Molecular weight: 416.38

Ref: TM-T201432