CAS 442644-28-2

JW 67

CAS: 442644-28-2

JW 67

Purity: ≥95%

Molecular weight: 394.38g/mol

Ref: 54-BUP03986

JW 67

CAS: 442644-28-2

JW 67 is an inhibitor of canonical Wnt pathway signaling.

Formula: C₂₁H₁₈N₂O₆

Purity: 99.02%

Color and Shape: Solid

Molecular weight: 394.38

Ref: TM-T22884

JW 67

CAS: 442644-28-2

JW 67 is a small molecule inhibitor of the protein β-catenin. It has been shown to inhibit the growth of cancer cells and to reduce inflammation by inhibiting the production of inflammatory cytokines such as TNF-α and IL-6. JW 67 binds to the protein β-catenin, preventing it from binding to its cellular targets and thereby causing a decrease in cell proliferation. The compound also blocks the formation of new blood vessels that are characteristic of choroidal neovascularization in patients with age-related macular degeneration. This compound is not active against other proteins that share structural similarities with β-catenin, such as Axin2, Notch1, or c-Myc.
JW 67 has been shown to be effective in treating atrial fibrillation by blocking the action of TGF-β1 on cardiac fibroblasts and cardiomyocytes, which leads to reduced fibrosis and increased contractility.

Formula: C₂₁H₁₈N₂O₆

Purity: Min. 95%

Molecular weight: 394.38 g/mol

Ref: 3D-SSA64428