CAS 442644-28-2

Formula: C21H18N2O6

InChI: InChI=1S/C21H18N2O6/c24-17-20(13-5-1-3-7-15(13)22-17)26-9-19(10-27-20)11-28-21(29-12-19)14-6-2-4-8-16(14)23-18(21)25/h1-8H,9-12H2,(H,22,24)(H,23,25)

InChI key: BTXRSHKJNDFHGA-UHFFFAOYSA-N

SMILES: C1C2(COC3(O1)C4=CC=CC=C4NC3=O)COC5(C6=CC=CC=C6NC5=O)OC2

JW 67

CAS: 442644-28-2

JW 67

Formula: C₂₁H₁₈N₂O₆

Purity: 99%

Molecular weight: 394.383

Ref: 54-BUP03986

JW 67

CAS: 442644-28-2

Formula: C₂₁H₁₈N₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 394.3774

Ref: IN-DA00DLW5

Trispiro[indoline-3,2'-[1,3]dioxane-5',5''-[1,3]dioxane-2'',3'''-indoline]-2,2'''-dione

CAS: 442644-28-2

Trispiro[indoline-3,2'-[1,3]dioxane-5',5''-[1,3]dioxane-2'',3'''-indoline]-2,2'''-dione

Formula: C₂₁H₁₈N₂O₆

Purity: 98%

Molecular weight: 394.38

Ref: IN-DG00802982

Trispiro[3H-indole-3,2′-[1,3]dioxane-5′,5′′-[1,3]dioxane-2′′,3′′′-[3H]indole]-2,2′′′(1H,1′′′H)-dione (9CI)

CAS: 442644-28-2

Purity: ≥97%(HPLC)

Molecular weight: 394.383

Ref: 10-F980519

JW 67

CAS: 442644-28-2

JW 67 is a small molecule inhibitor of the protein β-catenin. It has been shown to inhibit the growth of cancer cells and to reduce inflammation by inhibiting the production of inflammatory cytokines such as TNF-α and IL-6. JW 67 binds to the protein β-catenin, preventing it from binding to its cellular targets and thereby causing a decrease in cell proliferation. The compound also blocks the formation of new blood vessels that are characteristic of choroidal neovascularization in patients with age-related macular degeneration. This compound is not active against other proteins that share structural similarities with β-catenin, such as Axin2, Notch1, or c-Myc.
JW 67 has been shown to be effective in treating atrial fibrillation by blocking the action of TGF-β1 on cardiac fibroblasts and cardiomyocytes, which leads to reduced fibrosis and increased contractility.

Formula: C₂₁H₁₈N₂O₆

Purity: Min. 95%

Molecular weight: 394.38 g/mol

Ref: 3D-SSA64428

JW 67

CAS: 442644-28-2

JW 67 is an inhibitor of canonical Wnt pathway signaling.

Formula: C₂₁H₁₈N₂O₆

Purity: 99.02%

Color and Shape: Solid

Molecular weight: 394.38

Ref: TM-T22884